Patents by Inventor Hyung Joon Joo

Hyung Joon Joo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STEM CELL-DERIVED MATURE CARDIOMYOCYTES AND CARDIOVASCULAR DISEASE MODEL USING SAME
    Publication number: 20240084259
    Abstract: The present invention relates to stem cell-derived mature cardiomyocytes and a cardiovascular disease model using same and, more specifically, to differentiation into mature ventricular cardiomyocytes by culturing stem cells in a medium containing FGF4 and ascorbic acid, and use of the differentiated mature ventricular cardiomyocytes as a cardiovascular disease cell model. The mature ventricular cardiomyocytes, obtained by culturing stem cells in a medium containing FGF4 and ascorbic acid and inducing the differentiation thereof, and cardiovascular disease cell model using same according to the present invention are very useful for screening for cardiovascular disease therapeutic agents and evaluation of the toxicity of new drugs.
    Type: Application
    Filed: November 13, 2019
    Publication date: March 14, 2024
    Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Do-Sun LIM, Seung Cheol CHOI, Hyung Joon JOO, Jong-Ho KIM, Chi-Yeon PARK, Yongdoo PARK
  • NOVEL N-ACYLUREA DERIVATIVE AND COMPOSITION COMPRISING SAME FOR PREVENTION OR TREATMENT OF CARDIOVASCULAR DISEASE
    Publication number: 20220194928
    Abstract: The present invention relates to a novel N-acylurea derivative and the use thereof for the prevention or treatment of cardiovascular disease, and more particularly to a novel N-acylurea derivative, a pharmaceutical composition for prevention or treatment of cardiovascular disease, which contains the N-acylurea derivative as an active ingredient, and a method of preparing the N-acylurea derivative. The N-acylurea derivative according to the present invention can inhibit platelet aggregation by inhibiting the activity of talin in the intracellular matrix, and thus can be useful for the prevention or treatment of cardiovascular disease.
    Type: Application
    Filed: March 10, 2022
    Publication date: June 23, 2022
    Inventors: Soon Jun Hong, Chung Ho Kim, Hyung Joon Joo, Jong-Ho Kim, Ji-Young Park, Seung Cheol Choi, Chan-Sik Yang, Jong Hwa Jung, Minseon Jeong, Miseon Ryu, Sugyeong Kwon
  • N-acylurea derivative and composition comprising same for prevention or treatment of cardiovascular disease
    Patent number: 11306073
    Abstract: The present invention relates to a novel N-acylurea derivative and the use thereof for the prevention or treatment of cardiovascular disease, and more particularly to a novel N-acylurea derivative, a pharmaceutical composition for prevention or treatment of cardiovascular disease, which contains the N-acylurea derivative as an active ingredient, and a method of preparing the N-acylurea derivative. The N-acylurea derivative according to the present invention can inhibit platelet aggregation by inhibiting the activity of talin in the intracellular matrix, and thus can be useful for the prevention or treatment of cardiovascular disease.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: April 19, 2022
    Assignees: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERTION FOUNDATION
    Inventors: Soon Jun Hong, Chung Ho Kim, Hyung Joon Joo, Jong-Ho Kim, Ji-Young Park, Seung Cheol Choi, Chan-Sik Yang, Jong Hwa Jung, Minseon Jeong, Miseon Ryu, Sugyeong Kwon
  • NOVEL N-ACYLUREA DERIVATIVE AND COMPOSITION COMPRISING SAME FOR PREVENTION OR TREATMENT OF CARDIOVASCULAR DISEASE
    Publication number: 20190119261
    Abstract: The present invention relates to a novel N-acylurea derivative and the use thereof for the prevention or treatment of cardiovascular disease, and more particularly to a novel N-acylurea derivative, a pharmaceutical composition for prevention or treatment of cardiovascular disease, which contains the N-acylurea derivative as an active ingredient, and a method of preparing the N-acylurea derivative. The N-acylurea derivative according to the present invention can inhibit platelet aggregation by inhibiting the activity of talin in the intracellular matrix, and thus can be useful for the prevention or treatment of cardiovascular disease.
    Type: Application
    Filed: December 22, 2016
    Publication date: April 25, 2019
    Inventors: Soon Jun Hong, Chung Ho Kim, Hyung Joon Joo, Jong-Ho Kim, Ji-Young Park, Seung Cheol Choi, Chan-Sik Yang, Jong Hwa Jung, Minseon Jeong, Miseon Ryu, Sugyeong Kwon
  • METHOD FOR FORMING ENDOTHELIAL CELLS
    Publication number: 20150368617
    Abstract: The present application discloses a method of promoting differentiation and expansion of endothelial cells (EC) and cardiomyocytes from a pluripotent cell, which includes contacting the pluripotent cell with a Rho-associated protein kinase (ROCK) suppressor.
    Type: Application
    Filed: May 7, 2014
    Publication date: December 24, 2015
    Applicant: Korea Advanced Institute of Science and Technology (KAIST)
    Inventors: Gou Young KOH, Hyung Joon Joo, Dong Kyu Choi, Jin-Sung Park, Sung Woo Cho