Abstract: Disclosed herein, inter alia, are inhibitors of alpha 2 beta 1 integrin and methods of using the same.

Abstract: Disclosed herein, inter alia, are inhibitors of integrin alpha 2 beta 1 and methods of using the same.

Abstract: Disclosed herein, inter alia, are inhibitors of alpha 2 beta 1 integrin and methods of using the same.

Abstract: The disclosure provides, inter alia, alpha-5 beta-1 inhibitors, pharmaceutical compositions comprising alpha-5 beta-1 inhibitors, methods for treating diseases using alpha-5 beta-1 inhibitors, and processes for making alpha-5 beta-1 inhibitors.

Abstract: Disclosed herein, inter alia, are inhibitors of integrin alpha 2 beta 1 and methods of using the same.

Abstract: Provided herein are systems, methods and reagents for determining interactors (proteins or nucleic acids) that interact with a protein of interest. The subject system, methods and reagents advantageously allow for the identification of weak and transient protein-protein interactions. Such subject system, methods and reagents are useful, for example, for the determination of specific protein-interactor interactions that exist in particular diseases. Determination of these differences is useful, for example, in the drug development for the treatment of such diseases.

Abstract: The disclosure provides, inter alia, alpha-5 beta-1 inhibitors, pharmaceutical compositions comprising alpha-5 beta-1 inhibitors, methods for treating diseases using alpha-5 beta-1 inhibitors, and processes for making alpha-5 beta-1 inhibitors.

Abstract: Disclosed herein, inter alia, are inhibitors of integrin alpha 5 beta 1 and methods of using the same.

Abstract: Disclosed herein, inter alia, are inhibitors of integrin alpha 5 beta 1 and methods of using the same.

Abstract: Improving the knowledge about how hydraulic fracture networks are generated in subsurface shale volumes in unconventional wellbores may be accomplished with various configurations of at least one diagnostic lateral wellbore using at least one diagnostic device disposed in the diagnostic lateral wellbore. By extending diagnostic lateral wellbores from adjacent lateral wellbores and/or separately drilling diagnostic lateral wellbores, and analyzing signals received by diagnostic devices placed in the diagnostic lateral wellbores, knowledge about fracture networks, the parameters that control fracture geometry and reservoir production and how reservoirs react to refracturing techniques may be greatly improved. Additionally, such diagnostic lateral wellbores can provide quicker location of sweet-spot horizons in reservoirs.

Abstract: Provided herein, inter alia, are methods and compositions for inhibiting ?v?1 integrin and for treating fibrosis.

Abstract: Provided herein are systems, methods and reagents for determining interactors (proteins or nucleic acids) that interact with a protein of interest. The subject system, methods and reagents advantageously allow for the identification of weak and transient protein-protein interactions. Such subject system, methods and reagents are useful, for example, for the determination of specific protein-interactor interactions that exist in particular diseases. Determination of these differences is useful, for example, in the drug development for the treatment of such diseases.

Abstract: Provided herein, inter alia, are methods and compositions for inhibiting ?v?1 integrin and for treating fibrosis.

Abstract: Provided herein, inter alia, are methods and compositions for inhibiting ?v?1 integrin and for treating fibrosis.

Abstract: Provided are compounds according to formula (Ia) or (Ib) as described herein, that are capable of modulating the activity of influenza viruses (e.g., influenza A virus), for example, via interaction with the M2 transmembrane protein, and other similar viroporins. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds according to according to formulas (Ia?) or (Ib), as described herein.

Abstract: Provided herein, inter alia, are methods and compositions for inhibiting ?v?1 integrin and for treating fibrosis.

Abstract: Improving the knowledge about how hydraulic fracture networks are generated in subsurface shale volumes in unconventional wellbores may be accomplished with various configurations of at least one diagnostic lateral wellbore using at least one diagnostic device disposed in the diagnostic lateral wellbore. By extending diagnostic lateral wellbores from adjacent lateral wellbores and/or separately drilling diagnostic lateral wellbores, and analyzing signals received by diagnostic devices placed in the diagnostic lateral wellbores, knowledge about fracture networks, the parameters that control fracture geometry and reservoir production and how reservoirs react to refracturing techniques may be greatly improved. Additionally, such diagnostic lateral wellbores can provide quicker location of sweet-spot horizons in reservoirs.

Abstract: Provided herein, inter alia, are methods and compositions for inhibiting ?v?1 integrin and for treating fibrosis.

Abstract: Provided are compounds according to formula (Ia) or (Ib) as described herein, that are capable of modulating the activity of influenza viruses (e.g., influenza A virus), for example, via interaction with the M2 transmembrane protein, and other similar viroporins. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds according to according to formulas (Ia?) or (Ib), as described herein.

Abstract: A method for determining the fracture spacing for a first set of fractures of a wellbore. A first fracture dimension is chosen from the smaller of the length or height of a first fracture and an expected second fracture dimension is chosen from the smaller of the expected length or expected height of a second fracture to be formed. An approximate position of the second fracture is determined from a percentage of the average of the first fracture dimension and the second fracture dimension. An approximate position of a third fracture is determined so that ratio of the distances from the first fracture and the second fracture are about equal to a ratio of the first fracture dimension and the second fracture dimension. The well may then be fractured at the approximate position of the second fracture and may be fractured at the approximate position of the third fracture.