Patents by Inventor Hyunjoon Kong
Hyunjoon Kong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250195663Abstract: In one embodiment, the invention relates to a process for producing a crystalline antioxidant comprising: (1) providing an aqueous solution comprising a hydrophilic antioxidant; and a polymer selected from hyaluronate-dopamine, alginate-dopamine, chitosan-dopamine, poly(ethylene glycol) dopamine and their derivatives, or mixtures thereof; (2) forming a liquid droplet of the aqueous solution, the droplet having a diameter, wherein polymer-induced nucleation of the antioxidant occurs in the liquid droplets; (3) crystallizing the crystalline antioxidant by performing at least one of: (a) subjecting the liquid droplet to thermal cycling between a lower temperature and a higher temperature, wherein antioxidant crystal growth occurs at the lower temperature and crystal dissolution occurs at the upper temperature; and maintaining the thermal cycling until the droplet contains one or two antioxidant crystals, and (b) subjecting the liquid droplet to shear deformation using a shear-induced mixing-on-a-chip device, wheType: ApplicationFiled: December 13, 2024Publication date: June 19, 2025Inventors: Hyunjoon KONG, Jonghwi LEE, Youngjun KIM, Hee Sun HAN, Ryan Cree MILLER
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Publication number: 20250127729Abstract: Patches configured to hold an oncogenic cargo and deliver the cargo in a controlled manner to a predetermined location of a specified tissue are disclosed. As one example, a patch can comprise a base layer configured to adhere to a predetermined location of a tissue and a hydrogel layer. The hydrogel layer can comprise a plurality of microchannels that are configured to store and release a gene-modifying vector over a time period and in a quantity sufficient to produce a somatic cell tumor through manipulation of the genome of somatic cells at the predetermined location.Type: ApplicationFiled: February 1, 2023Publication date: April 24, 2025Applicant: The Board of Trustees of the University of IllinoisInventors: Hyunjoon Kong, Byoungsoo Kim, Lawrence B. Schook, Kyle Schachtschneider, Lobna Elkhadragy, Maximillian Carlino
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Patent number: 12280492Abstract: Provided herein are manipulators for handling fragile layers and related methods of handling using the manipulators. The manipulators comprise a contact surface with thermally responsive recess features and a microelectric heater in thermal contact with the contact surface. In this manner, the manipulator is an electrothermal manipulator, with changes in temperature providing a contact force to pick-up a transferable layer material and a release force to facilitate release of the transferable from the manipulator.Type: GrantFiled: August 31, 2021Date of Patent: April 22, 2025Assignees: The Board of Trustees of the University of Illinois, Purdue Research FoundationInventors: Hyunjoon Kong, Byoungsoo Kim, Jonghwi Lee, Chi Hwan Lee, Min Ku Kim
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Patent number: 12201730Abstract: Provided herein are stimulus-responsive polymer microgelator particles that can activate fibrin fiber formation from their surfaces by actively ejecting thrombin to form an interconnected fibrin network with an increased elastic modulus and desirable microstructure. The use of the microgelators enables the decoupling of gelation rate and gel rigidity.Type: GrantFiled: April 2, 2021Date of Patent: January 21, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Hyunjoon Kong, Yu-Tong Hong, Yongbeom Seo
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Patent number: 11974982Abstract: Compositions comprising an active oxygen-responsive antioxidant crystal, methods of making them, and methods for controlling the dissolution rate and/or altering the crystallization behavior of an antioxidant are disclosed. The crystals comprise an antioxidant and a disulfide- or diselenide-crosslinked polymer that is adsorbed onto a surface of the antioxidant. Upon exposure to an active-oxygen stimulus, the polymer de-crosslinks to release the antioxidant from the composition in an amount effective to counteract the stimulus. While prior approaches to altering dissolution rates have relied on passive zero- or first-order kinetics that are independent of ROS levels, the inventive compositions actively respond by releasing antioxidant in an amount proportional to the concentration of active-oxygen species present. The crystallization methods are simple and scalable.Type: GrantFiled: March 30, 2021Date of Patent: May 7, 2024Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Hyunjoon Kong, Byoungsoo Kim, Jonghwi Lee, Youngjun Kim, Ryan Cree Miller
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Patent number: 11458221Abstract: Diatom microbubblers comprising diatom biosilica or other silica linked to a catalyst for the decomposition of hydrogen peroxide, such as manganese oxide (MnO2), platinum (Pt), CuO (copper II oxide), or zinc peroxide (ZnO2) particles or nanosheets, or catalase are provided. Further provided are methods of reducing or eliminating biofilm or biofouling conditions.Type: GrantFiled: August 14, 2019Date of Patent: October 4, 2022Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Hyunjoon Kong, Yongbeom Seo, Jiayu Leong, Yu-Heng Deng
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Publication number: 20220063110Abstract: Provided herein are manipulators for handling fragile layers and related methods of handling using the manipulators. The manipulators comprise a contact surface with thermally responsive recess features and a microelectric heater in thermal contact with the contact surface. In this manner, the manipulator is an electrothermal manipulator, with changes in temperature providing a contact force to pick-up a transferable layer material and a release force to facilitate release of the transferable from the manipulator.Type: ApplicationFiled: August 31, 2021Publication date: March 3, 2022Inventors: Hyunjoon KONG, Byoungsoo KIM, Jonghwi LEE, Chi Hwan LEE, Min Ku KIM
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Publication number: 20210308064Abstract: Provided herein are stimulus-responsive polymer microgelator particles that can activate fibrin fiber formation from their surfaces by actively ejecting thrombin to form an interconnected fibrin network with an increased elastic modulus and desirable microstructure. The use of the microgelators enables the decoupling of gelation rate and gel rigidity.Type: ApplicationFiled: April 2, 2021Publication date: October 7, 2021Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Hyunjoon KONG, Yu-Tong HONG, Yongbeom SEO
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Publication number: 20210308100Abstract: Compositions comprising an active oxygen-responsive antioxidant crystal, methods of making them, and methods for controlling the dissolution rate and/or altering the crystallization behavior of an antioxidant are disclosed. The crystals comprise an antioxidant and a disulfide- or diselenide-crosslinked polymer that is adsorbed onto a surface of the antioxidant. Upon exposure to an active-oxygen stimulus, the polymer de-crosslinks to release the antioxidant from the composition in an amount effective to counteract the stimulus. While prior approaches to altering dissolution rates have relied on passive zero- or first-order kinetics that are independent of ROS levels, the inventive compositions actively respond by releasing antioxidant in an amount proportional to the concentration of active-oxygen species present. The crystallization methods are simple and scalable.Type: ApplicationFiled: March 30, 2021Publication date: October 7, 2021Inventors: Hyunjoon KONG, Byoungsoo KIM, Jonghwi LEE, Youngjun KIM, Ryan Cree MILLER
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Publication number: 20200093947Abstract: Diatom microbubblers comprising diatom biosilica or other silica linked to a catalyst for the decomposition of hydrogen peroxide, such as manganese oxide (MnO2), platinum (Pt), CuO (copper II oxide), or zinc peroxide (ZnO2) particles or nanosheets, or catalase are provided. Further provided are methods of reducing or eliminating biofilm or biofouling conditions.Type: ApplicationFiled: August 14, 2019Publication date: March 26, 2020Inventors: Hyunjoon Kong, Yongbeom Seo, Jiayu Leong, Yu-Heng Deng
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Patent number: 9533073Abstract: The invention provides compositions and methods for making and using microvascular stamps for stimulation and spatial organization of neovessels in tissue.Type: GrantFiled: May 12, 2015Date of Patent: January 3, 2017Assignee: The Board of Trustees of the University of IllinoisInventors: Hyunjoon Kong, Rashid Bashir, Jaehyun Jeong, Vincent Chan, Chaenyung Cha, Pinar Zorlutuna
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Patent number: 9050180Abstract: The invention provides compositions and methods for making and using microvascular stamps for stimulation and spatial organization of neovessels in tissue.Type: GrantFiled: March 7, 2013Date of Patent: June 9, 2015Assignee: The Board of Trustees of the University of IllinoisInventors: Hyunjoon Kong, Rashid Bashir, Jaehyun Jeong, Vincent Chan, Chaenyung Cha, Pinar Zorlutuna
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Patent number: 7241338Abstract: Sprayable fiber reinforced hydraulically setting mortars exhibit strain hardening behavior, and comprise hydraulically setting cement, less than 4 weight percent matrix interactive fibers, a non-Newtonian additive, a superplasticizer, optionally a viscosity control agent, aggregate, and further additives. The ductile composites can be prepared by spraying in thicknesses higher than conventional sprayable mortars.Type: GrantFiled: September 30, 2003Date of Patent: July 10, 2007Assignee: The Regents of the University of MichiganInventors: Victor C. Li, Yun Yong Kim, Hyunjoon Kong
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Publication number: 20050066858Abstract: Sprayable fiber reinforced hydraulically setting mortars exhibit strain hardening behavior, and comprise hydraulically setting cement, less than 4 weight percent matrix interactive fibers, a non-Newtonian additive, a superplasticizer, optionally a viscosity control agent, aggregate, and further additives. The ductile composites can be prepared by spraying in thicknesses higher than conventional sprayable mortars.Type: ApplicationFiled: September 30, 2003Publication date: March 31, 2005Applicant: The Regents of the University of MichiganInventors: Victor Li, Yun Kim, Hyunjoon Kong