Patents by Inventor Hyunryul Ryu

Hyunryul Ryu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Liquid biopsy detection of leukemia using closed-loop microfluidics
    Patent number: 10697964
    Abstract: This invention describes a one-step technique for the simultaneous label-free detection and concentration of blast cells from a blood sample. Enrichment of blast cells is achieved using a closed loop microfluidics system, allowing continuous removal of waste and non-target cells to generate concentrated samples of high purity without the need for specific targeting of proteins by antibodies. The technique is highly effective for samples which cannot be purified in a single run. The application of detecting rare blast cells for monitoring minimal residual disease in leukemia patients is demonstrated. The sensitivity of the invention promotes the detection of blast cells in blood samples of early-stage patients.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: June 30, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Bee Luan Khoo, Jongyoon Han, Kyungyong Choi, Hyunryul Ryu
  • Particle isolation/enrichment using continuous closed-loop micro-fluidics
    Patent number: 10697871
    Abstract: The present invention encompasses a micro-fluidic system having a closed-loop configuration in which inertial micro-fluidic separation of particles and/or cells is continuously repeated by feeding part of the output back to the input so that the purity and/or concentration of the particles and/or cell is maximized. The invention also includes methods of using the micro-fluidic system.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: June 30, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Hyunryul Ryu, Kyungyong Choi, Jongyoon Han
  • Liquid Biopsy Detection of Leukemia Using Closed-Loop Microfluidics
    Publication number: 20180136210
    Abstract: This invention describes a one-step technique for the simultaneous label-free detection and concentration of blast cells from a blood sample. Enrichment of blast cells is achieved using a closed loop microfluidics system, allowing continuous removal of waste and non-target cells to generate concentrated samples of high purity without the need for specific targeting of proteins by antibodies. The technique is highly effective for samples which cannot be purified in a single run. The application of detecting rare blast cells for monitoring minimal residual disease in leukemia patients is demonstrated. The sensitivity of the invention promotes the detection of blast cells in blood samples of early-stage patients.
    Type: Application
    Filed: October 6, 2017
    Publication date: May 17, 2018
    Inventors: Bee Luan Khoo, Jongyoon Han, Kyungyong Choi, Hyunryul Ryu
  • PARTICLE ISOLATION/ENRICHMENT USING CONTINUOUS CLOSED-LOOP MICRO-FLUIDICS
    Publication number: 20180128723
    Abstract: The present invention encompasses a micro-fluidic system having a closed-loop configuration in which inertial micro-fluidic separation of particles and/or cells is continuously repeated by feeding part of the output back to the input so that the purity and/or concentration of the particles and/or cell is maximized. The invention also includes methods of using the micro-fluidic system.
    Type: Application
    Filed: October 6, 2017
    Publication date: May 10, 2018
    Inventors: Hyunryul Ryu, Kyungyong Choi, Jongyoon Han