Patents by Inventor Hyunsoo Shawn JE

Hyunsoo Shawn JE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR TREATING ANGELMAN SYNDROME AND RELATED DISORDERS
    Publication number: 20230042176
    Abstract: The present invention relates to methods of treating or ameliorating seizures relating to disruptions in Ubiquitin Protein Ligase E3A (UBE3A) gene. More particularly, the invention relates to the use of BK channel antagonists for the prophylaxis or treatment of seizures in a subject with Angelman syndrome or related autism spectrum disorder (ASD). In some embodiments, BK channel antagonist is Paxilline, iberiotoxin (IBTX) or GAL-021.
    Type: Application
    Filed: December 18, 2020
    Publication date: February 9, 2023
    Inventors: Hyunsoo Shawn JE, Qiang YUAN, Xuyang SUN
  • GENERATION OF MIDBRAIN-SPECIFIC ORGANOIDS FROM HUMAN PLURIPOTENT STEM CELLS
    Publication number: 20190169576
    Abstract: The present disclosure provides a method of deriving and maintaining a midbrain-like organoid in culture, comprising (a) culturing pluripotent stem cells to obtain neuronal lineage embryoid bodies; (b) culturing the neuronal lineage embryoid bodies from (a) to obtain midbrain regionalized tissues; (c) embedding and culturing the midbrain regionalized tissues from (b) in an extracellular matrix to obtain neuroepithelial tissues; and (c) culturing the neuroepithelial tissues from (c) to obtain a midbrain-like organoid.
    Type: Application
    Filed: March 14, 2017
    Publication date: June 6, 2019
    Inventors: Junghyun JO, Huck Hui NG, Hyunsoo Shawn JE