Patents by Inventor Hyun Sook Lee
Hyun Sook Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230130510Abstract: Disclosed herein is a method for manufacturing a hydrogen sensor, the method comprising the steps of: disposing a thin film made of a transition metal or an alloy thereof on a surface of elastic substrate; applying a tensile force in a repetitive manner to the elastic substrate to form a nanocrack on the thin film disposed on the surface of the elastic substrate; and injecting hydrogen gas into the formed nanocrack and then removing the hydrogen gas to form a nanogap, wherein the tensile force in the step of forming a nanocrack is applied to an extent that the elastic substrate has a tensile strain of 25% to 100%.Type: ApplicationFiled: June 21, 2022Publication date: April 27, 2023Inventors: Dong Gu Kim, Jang Hyeon Lee, Dae Sung Kwon, Hyun Soo Kim, Il Seon Yoo, Tae Ho Jeong, Woo Young Lee, Hyun Sook Lee, Se Young Park, Soo Min Lee, Jin Kyo Jeong, Hae Won Yoon
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Publication number: 20230111706Abstract: A method for treating cancer in a human subject includes initiating a cancer therapy on the human subject, preparing a biological sample from the human subject; (i) mixing the biological sample with an antibody or aptamer that specifically binds to an MEST protein, or (ii) obtaining mRNA of a nucleotide sequence encoding the MEST protein from the biological sample, and synthesizing and amplifying cDNA from the mRNA, detecting the MEST protein bound to the antibody or aptamer, or an expression of the cDNA, determining if the detected MEST or a level of the expression is higher than that in a normal human subject, determining responsiveness of the cancer to the cancer therapy by the detected MEST or the level of the expression, and continuing the cancer therapy to treat the cancer if it is determined that there is the responsiveness of the cancer to the cancer therapy.Type: ApplicationFiled: December 9, 2022Publication date: April 13, 2023Inventors: SUNG GYUN KANG, HYUN SOOK LEE, JUNG-HYUN LEE, SANG-JIN KIM, KAE KYONG KWON, HYUNG-SOON YIM, YUN JAE KIM, YOUNG OK HWANG, WOOK JIN, YONG KYUN CHO
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Publication number: 20220213463Abstract: The present invention relates to an Fe—S fusion protein acting as an electron transport chain, a novel carbon monoxide:formate oxidoreductase (CFOR) including the Fe—S fusion protein, novel Thermococcus strain BCF12 transformed with CFOR, and the use thereof. According to the present invention, two different enzymes may be physically linked directly to each other through the Fe—S fusion protein of the present invention, and thus electrons generated from any one enzyme may be transported directly to another enzyme through the Fe—S cluster of the Fe—S fusion protein. Accordingly, a reaction that produces a target substance with high efficiency by directly supplying electrons necessary for the production of the target substance is possible without leakage of electrons generated in any one enzyme. In addition, the present invention has an advantage in that the overall enzyme reaction rate and yield can be dramatically improved using a new electron transport reaction.Type: ApplicationFiled: November 28, 2018Publication date: July 7, 2022Inventors: Jung-Hyun LEE, Jae Kyu LIM, Hyun Sook LEE, Sung Gyun KANG, Kae Kyoung KWON, Yun Jae KIM, Ji-in YANG
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Patent number: 11242366Abstract: According to aspects of the present invention, a peptide with any one sequence of SEQ ID NOS:1 to 3 exhibits high selective binding affinity to a target and the microcapsule has superior physicochemical stability. Therefore, the cosmetic composition containing the microcapsule linked to the peptide manifests high delivery efficiency of an active ingredient included in the capsule to target cells, thereby exhibiting superior skin-condition improvement effects.Type: GrantFiled: January 19, 2018Date of Patent: February 8, 2022Assignee: KOLMAR KOREA CO., LTD.Inventors: Sang Keun Han, Hyun Sook Lee, Eun Ah Kim, Seung Min Hyun, Hyeong Choi, So Yoon Baek, Jae Hwa Hong, Chae Mi Lim, Da Jeong Bak, Hye Jin Jo, Hak Sung Lee, Ji Hun Park, Eun Young Lee
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Publication number: 20200190143Abstract: According to aspects of the present invention, a peptide with any one sequence of SEQ ID NOS:1 to 3 exhibits high selective binding affinity to a target and the microcapsule has superior physicochemical stability. Therefore, the cosmetic composition containing the microcapsule linked to the peptide manifests high delivery efficiency of an active ingredient included in the capsule to target cells, thereby exhibiting superior skin-condition improvement effects.Type: ApplicationFiled: January 19, 2018Publication date: June 18, 2020Inventors: Sang Keun HAN, Hyun Sook LEE, Eun Ah KIM, Seung Min HYUN, Hyeong CHOI, So Yoon BAEK, Jae Hwa HONG, Chae Mi LIM, Da Jeong BAK, Hye Jin JO, Hak Sung LEE, Ji Hun PARK, Eun Young LEE
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Publication number: 20190382853Abstract: A method for treating cancer in a human subject includes initiating a cancer therapy on the human subject, preparing a biological sample from the human subject; (i) mixing the biological sample with an antibody or aptamer that specifically binds to an MEST protein, or (ii) obtaining mRNA of a nucleotide sequence encoding the MEST protein from the biological sample, and synthesizing and amplifying cDNA from the mRNA, detecting the MEST protein bound to the antibody or aptamer, or an expression of the cDNA, determining if the detected MEST or a level of the expression is higher than that in a normal human subject, determining responsiveness of the cancer to the cancer therapy by the detected MEST or the level of the expression, and continuing the cancer therapy to treat the cancer if it is determined that there is the responsiveness of the cancer to the cancer therapy.Type: ApplicationFiled: September 3, 2019Publication date: December 19, 2019Inventors: SUNG GYUN KANG, HYUN SOOK LEE, JUNG-HYUN LEE, SANG-JIN KIM, KAE KYONG KWON, HYUNG-SOON YIM, YUN JAE KIM, YOUNG OK HWANG, WOOK JIN, YONG KYUN CHO
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Patent number: 9976124Abstract: The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing the strains in specific culture conditions. Thus, the methods of the invention have advantages in that they are more economic and efficient than existing hydrogen production methods and can produce hydrogen even at high temperature.Type: GrantFiled: November 29, 2013Date of Patent: May 22, 2018Assignee: KOREA OCEAN RESEARCH & DEVELOPMENT INSTITUTEInventors: Jung Hyun Lee, Sung Gyun Kang, Hyun Sook Lee, Sang Jin Kim, Kae Kyoung Kwon, Sun Shin Cha, Jung Ho Jeon, Yona Cho, Yun Jae Kim, Seung Seop Bae, Jae Kyu Lim, In Soon Jeong
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Publication number: 20170240971Abstract: The present invention is related to a kit for cancer diagnosis or prognosis analysis. MEST in the present invention is a biomarker for cancer having significantly improved accuracy and reliability, especially, breast cancer and liver cancer as well as metastatic cancer. In addition, the present invention could be used for cancer diagnosis and prognosis in a biological sample (for example, blood or serum) by using MEST only specifically expressed from cells and tissues of cancer patients.Type: ApplicationFiled: February 27, 2012Publication date: August 24, 2017Applicant: KOREA OCEAN RESEARCH & DEVELOPMENT INSTITUTEInventors: Sung Gyun KANG, Hyun Sook LEE, Jung-Hyun LEE, Sang-Jin KIM, Kae Kyong KWON, Hyung-Soon YIM, Yun Jae KIM, Young Ok HWANG, Wook JIN, Yong Kyun CHO
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Patent number: 9598705Abstract: The present invention provides Thermococcus onnurineus MC02 strain (accession no. KCTC12511BP) having increased hydrogen production ability, wherein the expression of rchA gene of the strain increases. Also, the present invention provides a method for producing the strain belonged to the genus Thermococcus having increased hydrogen production ability comprising, increasing the expression of rchA gene of the strain, and hydrogen production method using the strain.Type: GrantFiled: September 8, 2014Date of Patent: March 21, 2017Assignee: KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGYInventors: Sung Gyun Kang, Jung Hyun Lee, Hyun Sook Lee, Kae Kyoung Kwon, Tae Wan Kim, Yun Jae Kim, Min Sik Kim, Seong Hyuk Lee, Seung Seob Bae, Ae Ran Choi
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Patent number: 9267115Abstract: The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing the strains in specific culture conditions. Thus, the methods of the invention have advantages in that they are more economic and efficient than existing hydrogen production methods and can produce hydrogen even at high temperature.Type: GrantFiled: November 29, 2013Date of Patent: February 23, 2016Assignee: KOREA OCEAN RESEARCH & DEVELOPMENT INSTITUTEInventors: Jung Hyun Lee, Sung Gyun Kang, Hyun Sook Lee, Sang Jin Kim, Kae Kyoung Kwon, Sun Shin Cha, Jung Ho Jeon, Yona Cho, Yun Jae Kim, Seung Seop Bae, Jae Kyu Lim, In Soon Jeong
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Publication number: 20150132819Abstract: The present invention provides Thermococcus onnurineus MC02 strain (accession no. KCTC12511BP) having increased hydrogen production ability, wherein the expression of rchA gene of the strain increases. Also, the present invention provides a method for producing the strain belonged to the genus Thermococcus having increased hydrogen production ability comprising, increasing the expression of rchA gene of the strain, and hydrogen production method using the strain.Type: ApplicationFiled: September 8, 2014Publication date: May 14, 2015Inventors: Sung Gyun KANG, Jung Hyun LEE, Hyun Sook LEE, Kae Kyoung KWON, Tae Wan KIM, Yun Jae KIM, Min Sik KIM, Seong Hyuk LEE, Seung Seob BAE, Ae Ran CHOI
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Patent number: 8993291Abstract: The present invention relates to a Thermococcus onnurineus NA1 mutant having an increased ability to produce hydrogen from formate and a method of producing hydrogen the same. The Thermococcus onnurineus NA1 mutant according to the invention has an increased ability to produce hydrogen in a formate-containing medium compared to wild-type Thermococcus onnurineus NA1 and shows an increase in growth rate compared to the wild-type. The use of the mutant strain according to the invention can produce hydrogen with high efficiency from formate.Type: GrantFiled: April 14, 2014Date of Patent: March 31, 2015Assignee: Korea Institute of Ocean Science & TechnologyInventors: Sung Gyun Kang, Jung Hyun Lee, Kae Kyoung Kwon, Hyun Sook Lee, Tae Wan Kim, Yun Jae Kim, Min Sik Kim, Jeong Ho Jeon
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Publication number: 20140295519Abstract: The present invention relates to a Thermococcus onnurineus NA1 mutant having an increased ability to produce hydrogen from formate and a method of producing hydrogen the same. The Thermococcus onnurineus NA1 mutant according to the invention has an increased ability to produce hydrogen in a formate-containing medium compared to wild-type Thermococcus onnurineus NA1 and shows an increase in growth rate compared to the wild-type. The use of the mutant strain according to the invention can produce hydrogen with high efficiency from formate.Type: ApplicationFiled: April 14, 2014Publication date: October 2, 2014Applicant: KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGYInventors: Sung Gyun KANG, Jung Hyun LEE, Kae Kyoung KWON, Hyun Sook LEE, Tae Wan KIM, Yun Jae KIM, Min Sik KIM, Jeong Ho JEON
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Publication number: 20140248683Abstract: The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing the strains in specific culture conditions. Thus, the methods of the invention have advantages in that they are more economic and efficient than existing hydrogen production methods and can produce hydrogen even at high temperature.Type: ApplicationFiled: November 29, 2013Publication date: September 4, 2014Applicant: KOREA OCEAN RESEARCH & DEVELOPMENT INSTITUTEInventors: Jung Hyun LEE, Sung Gyun KANG, Hyun Sook LEE, Sang Jin KIM, Kae Kyoung KWON, Sun Shin CHA, Jung Ho JEON, Yona CHO, Yun Jae KIM, Seung Seop BAE, Jae Kyu LIM, In Soon JEONG
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Publication number: 20140178960Abstract: The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing the strains in specific culture conditions. Thus, the methods of the invention have advantages in that they are more economic and efficient than existing hydrogen production methods and can produce hydrogen even at high temperature.Type: ApplicationFiled: November 29, 2013Publication date: June 26, 2014Applicant: KOREA OCEAN RESEARCH & DEVELOPMENT INSTITUTEInventors: Jung Hyun LEE, Sung Gyun KANG, Hyun Sook LEE, Sang Jin KIM, Kae Kyoung KWON, Sun Shin CHA, Jung Ho JEON, Yona CHO, Yun Jae KIM, Seung Seop BAE, Jae Kyu LIM, In Soon JEONG
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Patent number: 8632471Abstract: The present invention relates to a noninvasive medical pulsimeter sensor using a hall device. By forming a pulse-sensing part array with a hall device as a magnetic sensor, over the skin-contacting part which consists of a magnetic material, the present invention increases the integrity of sensors, enables to understand the spatial characteristics of the pulse which cannot be determined by the conventional pressure sensors, minimize the time for searching the pulse, and is applicable widely to portable pulsimeters and the likes.Type: GrantFiled: February 20, 2007Date of Patent: January 21, 2014Inventors: Sang Suk Lee, Sang Dae Choi, Myoung Chone An, Young Kuen Choi, Ki Wang Kim, Dal Ho Park, Do Gwun Hwang, Soo Yong Ahn, Mi Sun Kim, Hyun Sook Lee, Hyeon Ho Kim
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Patent number: 8597926Abstract: The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing the strains in specific culture conditions. Thus, the methods of the invention have advantages in that they are more economic and efficient than existing hydrogen production methods and can produce hydrogen even at high temperature.Type: GrantFiled: September 7, 2009Date of Patent: December 3, 2013Assignee: Korea Ocean Research & Development InstituteInventors: Jung Hyun Lee, Sung Gyun Kang, Hyun Sook Lee, Sang Jin Kim, Kae Kyoung Kwon, Sun Shin Cha, Jung Ho Jeon, Yona Cho, Yun Jae Kim, Seung Seop Bae, Jae Kyu Lim, In Soon Jeong
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Patent number: 8257953Abstract: The present invention relates to a hyperthermophilic DNA polymerase and a preparation method thereof. The invention provides a novel hyperthermophilic DNA polymerase isolated from a Thermococcus sp. strain, a functional equivalent thereof, a protein having the amino acid sequence thereof, and a preparation method thereof. The DNA polymerase according to the invention is a DNA polymerase, which is hyperthermophilic and has an elongation ability and fidelity higher than those of prior commercial DNA polymerases. Thus, the DNA polymerase according to the invention will be useful in precision analysis, precision diagnosis, identification and the like, which require accurate PCR.Type: GrantFiled: October 2, 2006Date of Patent: September 4, 2012Assignee: Korean Ocean Research & Development InstituteInventors: Jung Hyun Lee, Suk Tae Kwon, Sung Gyun Kang, Sang Jin Kim, Jung Ho Hyun, Kae Kyoung Kwon, Yun Jae Kim, Hyun Sook Lee, Seung Seob Bae, Ki Hoon Nam, Jae Kyu Lim, Jung Ho Jeon, Sung Hyun Yang
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Patent number: 8232070Abstract: This invention relates to a gene encoding ?Np63? and screening methods of anticancer-drugs thereof, more specifically a gene encoding ?Np63? and a protein which is transported from nucleus to cytoplasm by contacting with potential anti-cancer-drugs in an epithelial cell carcinoma, a recombinant vector comprising said gene and reporter genes, and carcinoma cells comprising said vector. Also, This invention relates to high throughput screening methods of anticancer-drug comprising identifying the transportation of ?Np63? protein from nucleus to cytoplasm by contacting with potential anticancer-drug in a carcinoma cell.Type: GrantFiled: March 30, 2007Date of Patent: July 31, 2012Assignee: Seoul National University Industry FoundationInventors: Hyun Sook Lee, Jung Hwa Lee
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Patent number: D831676Type: GrantFiled: June 20, 2017Date of Patent: October 23, 2018Assignee: Hancom, Inc.Inventors: Soo Yeon Park, Yoon Ji Lee, Hyun Sook Lee, Hyun Ju An