Patents by Inventor Hyunwoo Yuk
Hyunwoo Yuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240399019Abstract: Methods of implanting biomaterials and devices in a patient, such as methods that include arranging an adhesive composition between and in contact with a biomaterial or a device, and a surface of a tissue of the patient. An adhesive composition may be configured to form at a surface of a tissue a conformal interface that reduces or minimizes infiltration of inflammatory cells at the conformal interface.Type: ApplicationFiled: March 15, 2024Publication date: December 5, 2024Inventors: Jingjing Wu, Jue Deng, Hyunwoo Yuk, Xuanhe Zhao
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Patent number: 12157801Abstract: Adhesion of conducting polymers on diverse insulating and conductive substrates via a hydrophilic adhesion layer, where one or more functional groups may be disposed between the substrate and the hydrophilic adhesion layer. Adhesion of the conducting polymers on the substrates is such that adhesion is maintained or substantially maintained in wet physiological environments.Type: GrantFiled: May 5, 2020Date of Patent: December 3, 2024Assignee: Massachusetts Institute of TechnologyInventors: Xuanhe Zhao, Hyunwoo Yuk, Akihisa Inoue
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Patent number: 12084604Abstract: A dry shape memory adhesive material for adhering a target surface in the presence of fluid and for providing tunable mechanical contraction of an adhered surface. The dry shape memory adhesive material is pre-stretched and dried to provide an adhesive structure that implements a hydration-based shape memory mechanism to achieve both uniaxial and biaxial contractions of the adhered surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.Type: GrantFiled: February 8, 2022Date of Patent: September 10, 2024Assignee: Massachusetts Institute of TechnologyInventors: Xuanhe Zhao, Hyunwoo Yuk, Heejung Roh
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Patent number: 12054653Abstract: An adhesive material that provides fast and robust adhesion on wet surfaces, where the adhesion formed is detachable on-demand. The adhesive material is formed of one or more hydrophilic polymers or copolymers grafted with one or more amine coupling groups via a plurality of cleavable physical bonds and/or cleavable covalent bonds and one or more cross linkers. Application of the adhesive material on a wet surface causes the adhesive material to absorb liquid to thereby swell the adhesive material to form a layer of hydrogel, resulting in the formation of temporary crosslinks followed by covalent crosslinks with the surface. Introducing a triggering agent cleaves the cleavable physical bonds and/or cleavable covalent bonds to allow for non-traumatic detachment of the adhesive material from the surface.Type: GrantFiled: May 24, 2021Date of Patent: August 6, 2024Assignee: Massachusetts Institute of TechnologyInventors: Xuanhe Zhao, Hyunwoo Yuk, Xiaoyu Chen
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Publication number: 20240238476Abstract: A method of adhering wet tissues together includes providing a dry adhesive material that contains one or more hydrophilic polymers, one or more amine coupling groups, and one or more cross linkers. The method including the steps of placing the dry adhesive material in contact with one or more wet tissue surfaces; allowing the dry adhesive material to absorb liquid from the one or more wet surfaces to thereby swell the adhesive material; allowing instant crosslinking by intermolecular interactions between the adhesive material and the one or more wet surfaces; and allowing quick covalent crosslinking between the adhesive material and the one or more wet surfaces.Type: ApplicationFiled: January 24, 2024Publication date: July 18, 2024Inventors: Xuanhe Zhao, Hyunwoo Yuk
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Publication number: 20240132758Abstract: A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.Type: ApplicationFiled: December 11, 2023Publication date: April 25, 2024Inventors: Xuanhe Zhao, Hyunwoo Yuk, Xinyu Mao, Christoph Nabzdyk
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Patent number: 11904067Abstract: Dry adhesive materials, particularly in the form of a film or tape, for adhering one or more wet surfaces comprising: (i) one or more hydrophilic polymers; (ii) one or more amine coupling groups, and (iii) one or more cross linkers. The dry adhesive material, when placed in contact with the one or more wet surfaces, absorbs liquid from the one or more wet surfaces, swells to form temporary crosslinking with the wet surface, and forms covalent crosslinking with the one or more wet surfaces.Type: GrantFiled: April 11, 2020Date of Patent: February 20, 2024Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Xuanhe Zhao, Hyunwoo Yuk
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Patent number: 11884845Abstract: A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.Type: GrantFiled: December 3, 2020Date of Patent: January 30, 2024Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCHInventors: Xuanhe Zhao, Hyunwoo Yuk, Xinyu Mao, Christoph Nabzdyk
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Publication number: 20240009346Abstract: A shape memory adhesive material for adhering and contracting wounds, particularly diabetic wounds, to facilitate their closure and healing. The shape memory adhesive is pre-stretched and dried to provide an adhesive structure with a pre-programmed strain, wherein the adhesive is capable of rapid robust adhesion followed by predictive contraction upon contact with a wet surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.Type: ApplicationFiled: February 11, 2022Publication date: January 11, 2024Inventors: Xuanhe Zhao, Hyunwoo Yuk, Heejung Roh, Aristidis Veves, Georgios Theocharidis
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Publication number: 20220259463Abstract: A dry shape memory adhesive material for adhering a target surface in the presence of fluid and for providing tunable mechanical contraction of an adhered surface. The dry shape memory adhesive material is pre-stretched and dried to provide an adhesive structure that implements a hydration-based shape memory mechanism to achieve both uniaxial and biaxial contractions of the adhered surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.Type: ApplicationFiled: February 8, 2022Publication date: August 18, 2022Inventors: Xuanhe Zhao, Hyunwoo Yuk, Heejung Roh
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Patent number: 11364658Abstract: A responsive material having an elastomeric matrix in which ferromagnetic particles are dispersed so as to have a predetermined magnetization pattern which, when exposed to an external magnetic field, changes the shape of the responsive material from an initial shape to a predetermined transformed shape dictated by the magnetization pattern. An initial shape of the responsive material is formed by direct ink printing while applying magnetic fields to a dispensing nozzle to align the particles and gives rise to the desired magnetization pattern.Type: GrantFiled: April 3, 2019Date of Patent: June 21, 2022Assignee: Massachusetts Institute of TechnologyInventors: Yoonho Kim, Xuanhe Zhao, Hyunwoo Yuk
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BIOADHESIVE MATERIALS AND MINIMALLY INVASIVE METHODS FOR ADHERING TISSUES WITH BIOADHESIVE MATERIALS
Publication number: 20220110619Abstract: Bioadhesive materials and methods for adhering biological tissues and blood vessels in a minimally invasive manner, wherein the bioadhesive materials are in folded bioadhesive sleeve configurations or in injectable bioadhesive forms adapted for delivery using minimally invasive procedures. The folded bioadhesive sleeve is disposed on the distal portions of a variety of minimally invasive devices for insertion to a target tissue site, then deployed and adhered to the target tissue site through actuation of the minimally invasive device. The injectable bioadhesive is disposed in a syringe and delivered to a target site via a catheter, then adhered to the target tissue by actuation of a minimally invasive device. Precise placement and adhesion to the target tissue site can be successfully accomplished solely through the actuation of the minimally invasive devices without the use of additional devices to assist in placement or actuation of the bioadhesive materials.Type: ApplicationFiled: October 8, 2021Publication date: April 14, 2022Inventors: Xuanhe Zhao, Hyunwoo Yuk, Sarah J Wu, Christoph Nabzdyk -
Publication number: 20210380848Abstract: An adhesive material that provides fast and robust adhesion on wet surfaces, where the adhesion formed is detachable on-demand. The adhesive material is formed of one or more hydrophilic polymers or copolymers grafted with one or more amine coupling groups via a plurality of cleavable physical bonds and/or cleavable covalent bonds and one or more cross linkers. Application of the adhesive material on a wet surface causes the adhesive material to absorb liquid to thereby swell the adhesive material to form a layer of hydrogel, resulting in the formation of temporary crosslinks followed by covalent crosslinks with the surface. Introducing a triggering agent cleaves the cleavable physical bonds and/or cleavable covalent bonds to allow for non-traumatic detachment of the adhesive material from the surface.Type: ApplicationFiled: May 24, 2021Publication date: December 9, 2021Inventors: Xuanhe Zhao, Hyunwoo Yuk, Xiaoyu Chen
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Publication number: 20210350725Abstract: A biorobotic hybrid heart that preserves organic intracardiac structures and mimics cardiac motion by image-guided replication of the cardiac myofiber architecture of the left ventricle with an active synthetic myocardium that drives the motion of the heart. The active soft tissue mimic is adhered to the organic endocardial tissue in a helical fashion using a custom-designed adhesive to form a flexible, conformable, and watertight organosynthetic interface.Type: ApplicationFiled: March 5, 2021Publication date: November 11, 2021Inventors: Clara Park, Xuanhe Zhao, Hyunwoo Yuk, Christopher Tam Nguyen, Ellen T. Roche
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Patent number: 11148389Abstract: Hydrogel-elastomer hybrids with interfacial bonding tougher than epidermis-dermis interfaces and functional micro-channels and micro-patterns can be created by pre-shaping both elastomers and hydrogels before bonding to conserve their micro-structures, modifying cured elastomer surfaces with benzophenone for chemical bonding with hydrogels, and harnessing dissipative properties of tough hydrogels to achieve robust interfaces.Type: GrantFiled: June 27, 2016Date of Patent: October 19, 2021Assignee: Massachusetts Institute of TechnologyInventors: Xuanhe Zhao, Hyunwoo Yuk
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Publication number: 20210163797Abstract: A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.Type: ApplicationFiled: December 3, 2020Publication date: June 3, 2021Inventors: Xuanhe Zhao, Hyunwoo Yuk, Xinyu Mao, Christoph Nabzdyk
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Patent number: 10954375Abstract: A robust hydrogel-solid hybrid formed of a substrate material having a nonporous and non-topographically patterned surface and a tough hydrogel bonded to the surface, the tough hydrogel having over 90 wt % water, and the hydrogel being bonded to provide interfacial toughness over 300 Jm?2, and even over 1000 Jm?2. The hydrogel is formed of polyacrylamide or polyethylene glycol diacrylate, which provide long-chain polymer networks, and chitosan, hyaluronan, or alginate, which provide mechanically dissipative components. An anchor, which can be a silane, a sulfide, or an amine, is disposed between the surface and the hydrogel to provide chemical bonding between the surface and the long-chain networks of the hydrogel.Type: GrantFiled: June 2, 2016Date of Patent: March 23, 2021Assignee: Massachusetts Institute of TechnologyInventors: Xuanhe Zhao, Shaoting Lin, Hyunwoo Yuk, Teng Zhang, German A P Hernandez
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Publication number: 20210038871Abstract: An expandable hydrogel structure formed of a housing with a superabsorbent material disposed and sealed therein, particularly wherein the housing is fabricated of a hydrogel membrane with a plurality of macropores providing fluid communication between the superabsorbent material and an exterior of the housing. Exposure of the superabsorbent material to an expansion trigger expands the housing from an initial size to an expanded size that is at least about 50 times to at least about 100 times the initial size. One or more therapeutic agents can further be disposed within the housing to provide controlled release of the therapeutic agents from the expanded housing for extended periods.Type: ApplicationFiled: January 15, 2019Publication date: February 11, 2021Inventors: Xuanhe Zhao, Hyunwoo Yuk, Xinyue Liu, Shaoting Lin, German Alberto Parada Hermandez
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Publication number: 20200377677Abstract: Adhesion of conducting polymers on diverse insulating and conductive substrates via a hydrophilic adhesion layer, where one or more functional groups may be disposed between the substrate and the hydrophilic adhesion layer. Adhesion of the conducting polymers on the substrates is such that adhesion is maintained or substantially maintained in wet physiological environments.Type: ApplicationFiled: May 5, 2020Publication date: December 3, 2020Inventors: Xuanhe Zhao, Hyunwoo Yuk, Akihisa Inoue
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Publication number: 20200368962Abstract: Systems and methods for three-dimensionally printing different configurations of a printed fiber using a single nozzle are provided. The provided systems and methods harness deformation, instability, and fracture of viscoelastic materials to adjust dimensionless parameters related to a speed of extrusion and a height of a nozzle to create the different configurations. A controller of the system can operate to create these different configurations using the single nozzle without having to change out hardware during the process. Instead, the dimensionless parameters can be adjusted while the printing is occurring to achieve the different configurations. The disclosure provides various systems for carrying out the printing, and methods of using the same.Type: ApplicationFiled: December 3, 2018Publication date: November 26, 2020Inventors: Hyunwoo Yuk, Xuanhe Zhao