Patents by Inventor Hywyn R. O. Churchill

Hywyn R. O. Churchill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Neutralizing Agents for Bacterial Toxins
    Publication number: 20110245153
    Abstract: Stabilized variable regions of the T cell receptor and methods of making the same using directed evolution through yeast display are provided. In one embodiment, the variable region is variable beta. In one embodiment, the stabilized T cell receptor variable regions have high affinity for a superantigen, such as TSST-1 or SEB. These T cell receptor variable regions are useful as therapeutics.
    Type: Application
    Filed: March 15, 2007
    Publication date: October 6, 2011
    Applicant: National Institutes of Health (NIH), U. S. Dept. of Health and Human Resources (DHHS) U. S. Govt.
    Inventors: David M. Kranz, Rebecca A. Buonpane, Hywyn R.O. Churchill, Eric J. Sundberg, Beenu Moza, Patrick Schlievert
  • Process for bioreduction of bisaryl ketone to bisaryl alcohol
    Patent number: 5900368
    Abstract: The present invention is directed to an improved process for making PDE IV inhibitors. In specific, this application describes a process for making and purifying a chiral bisaryl alcohol, an intermediate compound necessary for the preparation of PDE IV inhibitors such as CDP 840, by asymmetric bioreduction of a pro-chiral ketone. Furthermore, the bioprocess provides for production of each enantiomer of a bisaryl alcohol at elevated optical purity.This invention takes advantage of a microorganism's ability to reduce a pro-chiral bisaryl ketone to the chiral bisaryl alcohol. The alcohol is readily isolated from the media by solvent extraction, crystallography, or other purification method known to the skilled artisan. The chiral alcohol can then be converted to a PDE IV inhibitor, such as CDP 840, by methods well known in the art.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: May 4, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Michel M. Chartrain, Hywyn R.O. Churchill, Woo-Baeg Choi, Shigeko Yamazaki
  • Method of synthesizing furo[2,3-b]pyridine carboxylic acid esters
    Patent number: 5489685
    Abstract: A process is disclosed for rapid synthesis of substituted furanyl pyridines.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: February 6, 1996
    Assignee: Merck & Co., Ltd.
    Inventors: Ioannis Houpis, Audrey Molina, Joseph E. Lynch, Hywyn R. O. Churchill, Ralph P. Volante, Paul J. Reider, Woo-Baeg Choi