Patents by Inventor I. David MacDonald
I. David MacDonald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220193107Abstract: Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.Type: ApplicationFiled: March 7, 2022Publication date: June 23, 2022Inventors: Dechi GUAN, I. David MACDONALD
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Publication number: 20200129537Abstract: Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.Type: ApplicationFiled: December 26, 2019Publication date: April 30, 2020Inventors: Dechi GUAN, I. David MACDONALD
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Publication number: 20190060345Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: ApplicationFiled: February 22, 2018Publication date: February 28, 2019Inventors: Nancy HARRISON, I. David MACDONALD, Aniko TAKACS-COX, Robert MILLER
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Publication number: 20190022119Abstract: Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.Type: ApplicationFiled: February 16, 2018Publication date: January 24, 2019Inventors: Dechi GUAN, I. David MACDONALD
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Patent number: 9931356Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: August 23, 2016Date of Patent: April 3, 2018Assignee: METHYLATION SCIENCES INTERNATIONAL SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
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Patent number: 9925208Abstract: Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.Type: GrantFiled: February 23, 2015Date of Patent: March 27, 2018Assignee: METHYLATION SCIENCES INTERNATIONAL SRLInventors: Dechi Guan, I. David MacDonald
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Patent number: 9801896Abstract: Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.Type: GrantFiled: October 16, 2013Date of Patent: October 31, 2017Assignee: METHYLATION SCIENCES INTERNATIONAL SRLInventors: Dechi Guan, I. David MacDonald
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Publication number: 20170027976Abstract: Provided herein are drinkable or edible compositions comprising ademetionine (“SAM-e” or “S-adenosyl-L-methionine”). Also provided herein are methods for improving the delivery of ademetionine. Compositions and formulations provided herein increase ademetionine appealability. Also provided herein are methods of treating a disease or disorder in a subject by administering drinkable or edible compositions comprising ademetionine.Type: ApplicationFiled: April 13, 2015Publication date: February 2, 2017Inventors: Dechi GUAN, I. David MACDONALD, Melody LEVER
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Publication number: 20160361339Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: ApplicationFiled: August 23, 2016Publication date: December 15, 2016Inventors: Nancy HARRISON, I. David MACDONALD, Aniko TAKACS-COX, Robert MILLER
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Publication number: 20150283161Abstract: Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.Type: ApplicationFiled: October 16, 2013Publication date: October 8, 2015Inventors: Dechi Guan, I. David MacDonald
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Publication number: 20150164935Abstract: Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.Type: ApplicationFiled: February 23, 2015Publication date: June 18, 2015Inventors: Dechi GUAN, I. David MACDONALD
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Patent number: 8975238Abstract: Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.Type: GrantFiled: April 7, 2014Date of Patent: March 10, 2015Assignee: Methylation Sciences International SRLInventors: Dechi Guan, I. David MacDonald
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Publication number: 20140370108Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: ApplicationFiled: August 28, 2014Publication date: December 18, 2014Inventors: Nancy HARRISON, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
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Patent number: 8865203Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: December 5, 2012Date of Patent: October 21, 2014Assignee: Methylation Sciences International SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
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Publication number: 20140220129Abstract: Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.Type: ApplicationFiled: April 7, 2014Publication date: August 7, 2014Applicant: Methylation Sciences International SRLInventors: Dechi GUAN, I. David MACDONALD
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Patent number: 8580296Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: December 13, 2012Date of Patent: November 12, 2013Assignee: Methylation Sciences International SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
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Patent number: 8551515Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: December 13, 2012Date of Patent: October 8, 2013Assignee: Methylation Sciences International SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
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Publication number: 20130142847Abstract: Provided herein are compositions and methods to enhance the absorption of S-adenosylmethionine (SAMe) and methods of treating various disorders or diseases using non-parenteral SAMe formulations with enhanced-absorption and improved bioavailability. In certain embodiments, the enhanced bioavailability formulations provided herein may be used to treat a variety of diseases or disorders, such as for example, psychiatric disorders including, generalized anxiety disorder, obsessive compulsive disorder, post traumatic stress disorder, panic disorder, depressive disorders (e.g. major clinical depression) and dysthymia; as well as treating liver disorders, cancer, autoimmune disorders, inflammatory disorders, joint disorders, gastrointestinal disorders and cardiovascular disease.Type: ApplicationFiled: July 27, 2011Publication date: June 6, 2013Applicant: Methylation Sciences, Inc.Inventors: I. David MacDonald, Nancy Harrison, Aniko Takacs-Cox, Admir Purac, Almira Blazek-Welsh
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Patent number: 8329208Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: GrantFiled: July 28, 2010Date of Patent: December 11, 2012Assignee: Methylation Sciences International SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller
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Publication number: 20110027360Abstract: Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using SAMe formulations with improved pharmacokinetic profiles. More specifically, the invention is directed to methods of treating a disease or disorder in a subject and/or improving the nutritional status of a subject by administering formulations exhibiting improved pharmacokinetic profiles of exogenous SAMe. The method also includes the step of orally administering compositions of the invention to the subject once per day after overnight fast; that is prior to food intake in the morning.Type: ApplicationFiled: July 28, 2010Publication date: February 3, 2011Applicant: METHYLATION SCIENCES INTERNATIONAL SRLInventors: Nancy Harrison, I. David MacDonald, Aniko Takacs-Cox, Robert Miller