Abstract: The disclosure provides a method of active immunotherapy for a cancer patient, comprising administering vaccines against Globo series antigens (i.e., Globo H, SSEA-3 and SSEA-4). Specifically, the method comprises administering Globo H-CRM197 (OBI-833/821) in patients with cancer. The disclosure also provides a method of selecting a cancer patient who is suitable as treatment candidate for immunotherapy. Exemplary immune response can be characterized by reduction of the severity of disease, including but not limited to, prevention of disease, delay in onset of disease, decreased severity of symptoms, decreased morbidity and delayed mortality.

Abstract: A bicycle disk brake assembly includes a pressure-reducing cylinder attached to a caliper body and formed with an inner chamber and outer chamber. Upon application of an external pressure to a hydraulic fluid, which is filled within a fluid reservoir in the caliper body, the fluid flows from the reservoir to the outer chamber. When the fluid pressure in the outer chamber reaches a first value, an inner check valve is operated so as to permit flow of the fluid from the outer chamber to the inner chamber. Thereafter, when the fluid pressure in the inner chamber reaches a second value and when the external pressure is released, a resilient member biases the fluid in the inner chamber to activate an outer check valve, thereby permitting flow of the fluid from the inner chamber to the outer chamber and subsequently to the reservoir.