Abstract: The disclosure provides a method of active immunotherapy for a cancer patient, comprising administering vaccines against Globo series antigens (i.e., Globo H, SSEA-3 and SSEA-4). Specifically, the method comprises administering Globo H-CRM197 (OBI-833/821) in patients with cancer. The disclosure also provides a method of selecting a cancer patient who is suitable as treatment candidate for immunotherapy. Exemplary immune response can be characterized by reduction of the severity of disease, including but not limited to, prevention of disease, delay in onset of disease, decreased severity of symptoms, decreased morbidity and delayed mortality.

Abstract: A dot matrix hologram with a hidden image is disclosed, wherein the hidden image technology is applied to a dot matrix hologram. Although the hidden image technology has been used in a conventional hologram, it has not been used in a dot matrix hologram. Although the above two kinds of hologram both can show hidden images with illuminating laser light, the disclosed dot matrix hologram with a hidden image and the conventional hologram with a hidden image use different working principles and have different detailed characteristics to create hidden image regions.