Abstract: The present invention provides a morphology determining method of corneal topography, including: a parameter obtaining step, based on an original contour line of a cornea of a target subject as the reference, obtaining a relative displacement of each observation point of a contour line of the pressed cornea changed with time from the beginning of pressing the cornea by an external pressure to a predetermined time after the pressing is finished; a conversion step, performing a mathematical function conversion of the above relative displacement with respect to a spatial contour at each observation time point, so as to respectively obtain one or more order vibrational modes representing the contour line of the time points; and a determining step, respectively comparing the one or more order vibrational modes of the cornea of the target subject with a corresponding order vibrational mode of at least one reference cornea, and determining a morphology of the corneal topography of the cornea of the target subject.

Abstract: The present application provides a composition of corneal implantation, comprising: a collagen film, and renal proximal tubule cells which attached to the collagen film. In addition, the present application further provides a use of the composition of corneal implantation for implanting a patient with damaged cornea endothelium cells and a preparation method of the composition of corneal implantation.

Abstract: An implanting device is used for implanting a membrane in a biological tissue. The implanting device includes a sleeve, a membrane storage element, an injection element and a bubble generating element. The membrane storage element is fixed at the sleeve. The injection element is inserted in the sleeve and the membrane storage element, and includes a capturing end and connecting end. The capturing end is for capturing the membrane and has a hole. The bubble generating element is connected to the connecting end, and is for providing a gas that is then outputted via the hole. By the rotation of the injection element, the capturing end extends straight out of the membrane storage element or retracts straight into the membrane storage element.

Abstract: A corneal young's modulus algorithm and system using the same is provided, comprising a tonometer and a computation unit. The computation unit comprises an algorithm for calculating young's modulus. The algorithm comprises: (S1) read at least one parameter measured by a tonometer; (S2) apply the at least one parameter and an initial value of Young's modulus to a first equation to obtain an inner deformation amount and an outer deformation amount; (S3) apply the inner deformation amount and the outer deformation amount to a second equation to obtain a calculated deformation amount; (S4) determine if an error value between the calculated deformation amount and the actual deformation amount is minimal; and (S5) obtain Young's modulus.

Abstract: An implanting device is used for implanting a membrane in a biological tissue. The implanting device includes a sleeve, a membrane storage element, an injection element and a bubble generating element. The membrane storage element is fixed at the sleeve. The injection element is inserted in the sleeve and the membrane storage element, and includes a capturing end and connecting end. The capturing end is for capturing the membrane and has a hole. The bubble generating element is connected to the connecting end, and is for providing a gas that is then outputted via the hole. By the rotation of the injection element, the capturing end extends straight out of the membrane storage element or retracts straight into the membrane storage element.

Abstract: The present invention provides an acoustic wave intraocular pressure detecting device and a method thereof, which uses a driver to generate a vibration wave on the skin or bones. The energy of the vibration wave is transmitted to the orbital bones via the skin and the skeletons. A standing wave of the basin effect is generated on the eyeball inside the orbital bones. The standing wave vibrates the eyeball or the cornea to generate an acoustic wave signal with a resonance frequency. The eyeball or the cornea emits the acoustic wave outwardly. A receiver receives the acoustic wave and converts the acoustic wave into an intraocular pressure (IOP) value.

Abstract: A corneal young's modulus algorithm and system using the same is provided, comprising a tonometer and a computation unit. The computation unit comprises an algorithm for calculating young's modulus. The algorithm comprises: (S1) read at least one parameter measured by a tonometer; (S2) apply the at least one parameter and an initial value of Young's modulus to a first equation to obtain an inner deformation amount and an outer deformation amount; (S3) apply the inner deformation amount and the outer deformation amount to a second equation to obtain a calculated deformation amount; (S4) determine if an error value between the calculated deformation amount and the actual deformation amount is minimal; and (S5) obtain Young's modulus.

Abstract: The present invention provides an acoustic wave intraocular pressure detecting device and a method thereof, which uses a driver to generate a vibration wave on the skin or bones. The energy of the vibration wave is transmitted to the orbital bones via the skin and the skeletons. A standing wave of the basin effect is generated on the eyeball inside the orbital bones. The standing wave vibrates the eyeball or the cornea to generate an acoustic wave signal with a resonance frequency. The eyeball or the cornea emits the acoustic wave outwardly. A receiver receives the acoustic wave and converts the acoustic wave into an intraocular pressure (IOP) value.

Abstract: A system and a method for monitoring change of intraocular pressure and a contact lens for sensing change of intraocular pressure are provided. The contact lens includes a first material layer and a first pattern. The center of the first material layer has an optical region, and the optical region corresponds to a cornea region of an eyeball. The first pattern is formed on the optical region. Furthermore, the contact lens may further include a second material layer and a second pattern. The second material layer is located on the first material layer. The second pattern is formed on the second material layer and overlaps with the first pattern to form a moire pattern.

Abstract: A composition for ex vivo culture of corneal endothelial cell and a method for used the composition are disclosed. The composition or the method is applied to ex vitro culture of the corneal endothelial cell to maintain the corneal endothelial cell in a hexagonal phenotype, and to prevent the corneal endothelial cell from endothelial-mesenchymal transformation (EnMT). Therefore, the corneal endothelial cell can maintain normal phenotype and function and can be used in the further application. The composition at least comprises an effective concentrated matrix metalloproteinase inhibitor (MMPI).

Abstract: A method for measuring corneal elastic constant and viscosity constant comprises steps of: ejecting compressed air toward a cornea of a live eye ball and measuring air pressure thereof; emitting infrared rays during an air ejecting period, for measuring corneal deformation caused by the compressed air applied to the cornea; and calculating an elastic constant and a viscosity constant of the cornea based on Kelvin-Voigt model by utilizing the corneal deformation measured via the infrared rays and the measured air pressure during the air ejecting period. One advantage of the present invention is to aid preliminary detection in eye diseases.

Abstract: A system and a method for monitoring change of intraocular pressure and a contact lens for sensing change of intraocular pressure are provided. The contact lens includes a first material layer and a first pattern. The center of the first material layer has an optical region, and the optical region corresponds to a cornea region of an eyeball. The first pattern is formed on the optical region. Furthermore, the contact lens may further include a second material layer and a second pattern. The second material layer is located on the first material layer. The second pattern is formed on the second material layer and overlaps with the first pattern to form a moire pattern.

Abstract: The disclosure relates to a platform of using zebrafish in screening candidates for treating and/or preventing myopia and keratoconus disease. The disclosure is mainly based on that Lumican, one of several SLRPs, plays an important role in the regulation of fibrillogenesis or the genes affecting the size of eyeballs in zebrafish, in addition to playing an important role in clinical myopia. Therefore, the disclosure uses the established zebrafish model to further identify the drugs affecting the expression of lumican and collagen fibrillogenesis, and/or the regulation of eyeball size. These drugs are potential candidates for treating myopia and/or keratoconus disease.