Patents by Inventor I. Paul Shapiro

I. Paul Shapiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for Identifying Substrate Specificity of Inhibitors of Gamma Secretase
    Publication number: 20110306071
    Abstract: The invention provides assays and methods for determining the substrate specificity of gamma secretase inhibitors and for identifying substrate-selective (and substrate isoform-selective) inhibitors of gamma secretase. The invention provides assays and methods for determining whether a compound inhibits gamma secretase in a site specific or substrate specific manner. The invention provides isolated polypeptide sequences comprising modified gamma secretase substrates, and polynucleotide sequences encoding the polypeptide sequences. The invention also provides compounds that inhibit gamma secretase, pharmaceutical compositions comprising such compounds, and methods of treating Alzheimer's disease using such compounds.
    Type: Application
    Filed: March 8, 2011
    Publication date: December 15, 2011
    Applicant: ELAN PHARMACEUTICALS, INC.
    Inventors: I. Paul Shapiro, Guriqbal S. Basi, Zhao Ren
  • Triple Assay System for Identifying Substrate Selectivity of Gamma Secretase Inhibitors
    Publication number: 20090163594
    Abstract: The invention provides assays and methods for determining whether a compound inhibits gamma secretase in a substrate specific manner. The invention provides an isolated cell wherein the cell stably expresses APP and at least one gamma secretase substrate other than APP. The invention provides assays and methods comprising contacting a cell with gamma secretase and detecting production of Abeta, detecting production of intracellular domain (ICD), and detecting a signal from a reporter gene under transcriptional control of the ICD. The invention also provides compounds that inhibit gamma secretase, pharmaceutical compositions comprising such compounds, and methods of treating Alzheimer's disease using such compounds.
    Type: Application
    Filed: October 31, 2008
    Publication date: June 25, 2009
    Applicant: ELAN PHARMACEUTICALS, INC.
    Inventors: I. Paul Shapiro, Guriqbal S. Basi, Zhao Ren, Xiao-Hua Chen
  • Compositions and Methods for Identifying Substrate Specificity of Inhibitors of Gamma Secretase
    Publication number: 20090023158
    Abstract: The invention provides assays and methods for determining the substrate specificity of gamma secretase inhibitors and for identifying substrate-selective (and substrate isoform-selective) inhibitors of gamma secretase. The invention provides assays and methods for determining whether a compound inhibits gamma secretase in a site specific or substrate specific manner. The invention provides isolated polypeptide sequences comprising modified gamma secretase substrates, and polynucleotide sequences encoding the polypeptide sequences. The invention also provides compounds that inhibit gamma secretase, pharmaceutical compositions comprising such compounds, and methods of treating Alzheimer's disease using such compounds.
    Type: Application
    Filed: July 14, 2008
    Publication date: January 22, 2009
    Applicant: Elan Pharmaceuticals, Inc.
    Inventors: I. Paul Shapiro, Guriqbal S. Basi, Zhao Ren