Patents by Inventor I. Peter Lamb

I. Peter Lamb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA spacer regulatory elements responsive to cytokines and methods for their use
    Patent number: 5814517
    Abstract: The present invention provides oligonucleotide sequences comprising DNA regulatory elements of the general sequence TTN.sub.X AA that bind activated transcriptional regulatory proteins in response to signaling molecules, such as cytokines. Further, the present invention also provides DNA constructs comprising the oligonucleotide sequences, cells transfected with the DNA constructs, and methods of using the DNA constructs and transfected cells to provide for the controlled expression of structural genes, for the detection and recovery of transcriptional regulatory proteins, and for measuring the ability of compounds to act as agonist and antagonists of gene transcription.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: September 29, 1998
    Assignee: Ligand Pharmaceuticals, Inc.
    Inventors: H. Martin Seidel, I. Peter Lamb
  • Methods for detecting modulators of cytokine action
    Patent number: 5712094
    Abstract: The present invention provides DNA constructs that contain oligonucleotide sequences comprising DNA regulatory elements of the general sequence TTN.sub.x AA that bind activated transcriptional regulatory proteins in response to signaling molecules, such as cytokines, an operably linked promoter and operably linked heterologous gene. The present invention also provides host cells transfected with such DNA constructs, as well as methods for measuring the ability of compounds to act as agonists and antagonists of gene transcription utilizing these DNA constructs and transfected host cells.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: January 27, 1998
    Assignee: Ligand Pharmaceuticals, Inc.
    Inventors: H. Martin Seidel, I. Peter Lamb, Shin-Shay Tian Chan