Abstract: Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein R1 is —NHR1a; R1a is —H or —C(O)CH(R1b)NHR1c; and R1b is selected from —H, —(C1-C4) alkyl and CH2OR1d and R1c is —H; or R1b and R1c, together with the atom to which they are attached, form a 5-membered heterocyclic ring; and R1d is H or —CH3.

Abstract: A computerized control system performs controlled pressure drilling in a formation with a drilling system according to a plan. A setup of at least the plan, the formation, and the drilling system is configured in the control system, and the setup is integrated with the drilling system. Functioning of the set up can then be conducted using one of a plurality of control modes, including an operating mode and a simulating mode. The control system functions the setup according to the operating mode for operational interaction with the setup using the integration of the setup with the drilling system. The control system can switch from the operating mode to the simulating mode for simulated interaction with the setup. The control system simulates for at least a time period the functioning of the setup according to the simulating mode using the integration of the setup with the drilling system. Current operations continue as at least one simulated operation or event is projected in the future.

Abstract: A computerized control system performs controlled pressure drilling in a formation with a drilling system according to a plan. A setup of at least the plan, the formation, and the drilling system is configured in the control system, and the setup is integrated with the drilling system. Functioning of the set up can then be conducted using one of a plurality of control modes, including an operating mode and a simulating mode. The control system functions the setup according to the operating mode for operational interaction with the setup using the integration of the setup with the drilling system. The control system can switch from the operating mode to the simulating mode for simulated interaction with the setup. The control system simulates for at least a time period the functioning of the setup according to the simulating mode using the integration of the setup with the drilling system. Current operations continue as at least one simulated operation or event is projected in the future.

Abstract: A compound of the formula ##STR1## where R, which may be the same or different, is selected from at least one of hydrogen, methyl, ethyl and phenyl, at least one R on each --OCHR--CHR-- unit being hydrogen; where m is an integer selected from 1-100; where n is an integer selected from 8 and 9. The preferred process of preparation is by the reaction of alkylene oxide with linoleyl alcohol in the presence of a catalyst which is a Bronsted base. The compounds are useful as reactive surfactants in aqueous emulsion polymerisation processes.

Abstract: A compound of the formula ##STR1## where R, which may be the same or different, is selected from at least one of hydrogen, methyl, ethyl and phenyl, at least one R on each --OCHR--CHR-- unit being hydrogen; where m is an integer selected from 1-100; where n is an integer selected from 8 and 9. The preferred process of preparation is by the reaction of alkylene oxide with linoleyl alcohol in the presence of a catalyst which is a Bronsted base.The compounds are useful as reactive surfactants in aqueous emulsion polymerisation processes.