Patents by Inventor Iain S. MacPherson

Iain S. MacPherson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA display of folded RNA libraries enabling RNA-SELEX without reverse transcription
    Patent number: 11976273
    Abstract: The present invention is directed to the method for selecting an RNA molecule that binds to a target molecule and a kit for carrying out the method. This method includes: providing a pool of oligonucleotide complexes that each comprise a ds-DNA molecule and an RNA molecule, the ds-DNA molecule comprising a first DNA strand at least partially annealed to a first region of the RNA molecule, whereby a second region of the RNA molecule is free to adopt a secondary structure; exposing the pool to a target molecule and allowing the second region of the RNA to bind the target molecule; and selecting from the pool one or more oligonucleotide complexes comprising an RNA molecule having the second region bound to the target molecule.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: May 7, 2024
    Assignee: Brandeis University
    Inventors: Iain S. MacPherson, Isaac J. Krauss
  • Methods for the development of vaccines based on oligosaccharide-oligonucleotide conjugates
    Patent number: 10125162
    Abstract: Described herein are oligosaccharide-oligonucleotide conjugates useful as vaccines against one or more human or veterinary therapeutic indications, and methods of synthesizing and identifying them. The conjugates may be identified using non-human antibodies as binding targets, thereby expanding the power and scope of the invention. Efficacious conjugates may be identified through an iterative screening process.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: November 13, 2018
    Assignee: Brandeis University
    Inventors: Isaac J. Krauss, Lizbeth K. Hedstrom, Iain S. MacPherson
  • METHODS FOR THE DEVELOPMENT OF VACCINES BASED ON OLIGOSACCHARIDE-OLIGONUCLEOTIDE CONJUGATES
    Publication number: 20160051690
    Abstract: Described herein are oligosaccharide-oligonucleotide conjugates useful as vaccines against one or more human or veterinary therapeutic indications, and methods of synthesizing and identifying them. The conjugates may be identified using non-human antibodies as binding targets, thereby expanding the power and scope of the invention. Efficacious conjugates may be identified through an iterative screening process.
    Type: Application
    Filed: June 19, 2015
    Publication date: February 25, 2016
    Inventors: Isaac J. KRAUSS, Lizbeth K. HEDSTROM, Iain S. MACPHERSON
  • Methods for the development of vaccines based on oligosaccharide-oligonucleotide conjugates
    Patent number: 9080169
    Abstract: Described herein are oligosaccharide-oligonucleotide conjugates useful as vaccines against one or more human or veterinary therapeutic indications, and methods of synthesizing and identifying them. The conjugates may be identified using non-human antibodies as binding targets, thereby expanding the power and scope of the invention. Efficacious conjugates may be identified through an iterative.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: July 14, 2015
    Assignee: Brandeis University
    Inventors: Isaac Jonathan Krauss, Lizbeth K. Hedstrom, Iain S. MacPherson
  • Methods for the Development of Vaccines Based on Oligosaccharide-Oligonucleotide Conjugates
    Publication number: 20130116417
    Abstract: Described herein are oligosaccharide-oligonucleotide conjugates useful as vaccines against one or more human or veterinary therapeutic indications, and methods of synthesizing and identifying them. The conjugates may be identified using non-human antibodies as binding targets, thereby expanding the power and scope of the invention. Efficacious conjugates may be identified through an iterative.
    Type: Application
    Filed: June 10, 2011
    Publication date: May 9, 2013
    Applicant: BRANDEIS UNIVERSITY
    Inventors: Isaac J. Krauss, Lizbeth K. Hedstrom, Iain S. MacPherson