Abstract: The present disclosure relates to pharmaceutical composition comprising 1) an amorphous solid dispersion comprising pralsetinib, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable hydrophilic polymer; and 2) an effervescent couple; and crystalline forms of pralsetinib and pralsetinib hydrochloride salt, which are useful as a RET selective inhibitors. The present disclosure also provides pharmaceutically acceptable compositions comprising the crystalline forms and methods of using said compositions in the treatment of various disorders.

Abstract: In various embodiments, the present invention provides a strong, synthetic elastomer materials (and related methods for making same) with mechanical properties that are controlled by the stereochemically-defined double bonds within their backbone, yet have physical properties that are derived from monomer selection and defined, modifiable, chain end groups. The use of the organocatalyzed, stereospecific addition of thiols to activated alkynes, affords isolated high molar mass materials (>100 kDa) via step-growth polymerization with high levels of cis- or trans-double bond content. Furthermore, in various aspects of the present invention, it has been found that changing the monomer composition and chain end groups provides additional control over the materials' physical properties to provide more efficient compounding with polar additives. Using this approach to elastomer synthesis, further end group modification and toughening through various vulcanization strategies are also possible.

Abstract: Disclosed herein are drug delivery devices and their use as a means of achieving controlled release of one or more active pharmaceutical ingredients. In particular, disclosed herein is an implantable drug delivery device comprising an inner core comprising one or more active pharmaceutical ingredients distributed throughout a first water-insoluble polymer; an intermediate coating positioned around the inner core, said intermediate coating comprising an acrylate polymer; and an outer coating positioned around the intermediate coating, said outer coating comprising a second water-insoluble polymer; wherein the acrylate polymer is formed from one or more monomers of formula (I).

Abstract: In various embodiments, the present invention provides a strong, synthetic elastomer materials (and related methods for making same) with mechanical properties that are controlled by the stereochemically-defined double bonds within their backbone, yet have physical properties that are derived from monomer selection and defined, modifiable, chain end groups. The use of the organocatalyzed, stereospecific addition of thiols to activated alkynes, affords isolated high molar mass materials (>100 kDa) via step-growth polymerization with high levels of cis- or trans-double bond content. Furthermore, in various aspects of the present invention, it has been found that changing the monomer composition and chain end groups provides additional control over the materials' physical properties to provide more efficient compounding with polar additives. Using this approach to elastomer synthesis, further end group modification and toughening through various vulcanization strategies are also possible.

Abstract: The present invention relates to the dissemination of digital media. In one aspect of the present invention, a method for disseminating content is provided, the method comprising: one or more rights holders providing one or more items of content to a database; the rights holders directing parsing of the content into content elements; the rights holders associating pricing conditions and dissemination conditions with the content; one or more editors assembling the content elements into one or more compilations; and one or more consumers purchasing one or more of the compilations.

Abstract: A metallurgical vessel having a cylindrical upper end section (21) and a top section (22) fitted to the upper end of section (21) to form a top closure of the vessel about a central opening (24) through which to extend a gas injection lance for injecting gas into the vessel. Top section (22) is formed as a two-part domed construction comprising an outer annular panel (71) welded to the vessel top section (21) and an inner annular panel (72) removably fastened to outer panel (71), both panels being formed with inwardly concave curvature so as to form together the continuously domed top section (22). The two panels (71, 72) are fastened together by clamping bolts (79) extended through outturned flanges (76, 77) formed on annular flanges standing up from the panels (71, 72). On release of bolts (79) panel (72) is removable to provide access to the interior of the vessel.

Abstract: The present invention shows a fish cleaning device comprising a cleaning board member with a work surface upon which a fish to be cleaned may be disposed during cleaning. The board is provided with a means to grip the fish during the cleaning operation. A knife slot is also provided to keep a knife in a convenient location for use. In addition, the board is also provided with a knife holder, to store the knife during transportation and storage. The fish cleaning device is also provided with a refuse collection member, which may be mounted and demounted on the cleaning board, and which may have a refuse collection bag attached, into which the refuse of a fish cleaning operation may be conveyed.