Patents by Inventor Ian A. Cook
Ian A. Cook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230093826Abstract: The present disclosure relates to methods, devices, and systems used for the treatment of and/or promoting recovery from various neurological disorders and conditions, including epilepsy and other seizure disorders and movement and other related disorders, as well as for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve.Type: ApplicationFiled: September 28, 2022Publication date: March 30, 2023Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
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Publication number: 20220378436Abstract: Thin-film mesh for medical devices, including stent and scaffold devices, and related methods are provided. Micropatterned thin-film mesh, such as thin-film Nitinol (TFN) mesh, may be fabricated via sputter deposition on a micropatterned wafer. The thin-film mesh may include slits to be expanded into pores, and the expanded thin-film mesh used as a cover for a stent device. The stent device may include two stent modules that may be implanted at a bifurcated aneurysm such that one module passes through a medial surface of the other module. The thin-film mesh may include pores with complex, fractal, or fractal-like shapes. The thin-film mesh may be used as a scaffold for a scaffold device. The thin-film scaffold may be placed in a solution including structural protein such as fibrin, seeded with cells, and placed in the body to replace or repair tissue.Type: ApplicationFiled: August 1, 2022Publication date: December 1, 2022Inventors: Colin Kealey, Ian A. Cook, Vikas Gupta
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Publication number: 20220331581Abstract: The present disclosure relates to methods, devices and systems used for the treatment of neurological disorders via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infratrochlear, auriculotermporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal, infraorbital, and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein. Systems and devices configured for therapeutic stimulation of the branches of the trigeminal nerves, such as the superficial trigeminal nerve, and their methods of application are also described.Type: ApplicationFiled: June 30, 2022Publication date: October 20, 2022Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC.Inventors: Christopher DeGiorgio, Ian A. Cook, Leon Ekchian
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Patent number: 11399841Abstract: Thin-film mesh for medical devices, including stent and scaffold devices, and related methods are provided. Micropatterned thin-film mesh, such as thin-film Nitinol (TFN) mesh, may be fabricated via sputter deposition on a micropatterned wafer. The thin-film mesh may include slits to be expanded into pores, and the expanded thin-film mesh used as a cover for a stent device. The stent device may include two stent modules that may be implanted at a bifurcated aneurysm such that one module passes through a medial surface of the other module. The thin-film mesh may include pores with complex, fractal, or fractal-like shapes. The thin-film mesh may be used as a scaffold for a scaffold device. The thin-film scaffold may be placed in a solution including structural protein such as fibrin, seeded with cells, and placed in the body to replace or repair tissue.Type: GrantFiled: June 6, 2017Date of Patent: August 2, 2022Assignee: MONARCH BIOSCIENCES, INC.Inventors: Colin Kealey, Ian A. Cook, Vikas Gupta
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Publication number: 20210251785Abstract: A thin-film covered stent device may include a thin-film mesh and a stent backbone covered by the thin-film mesh, thereby forming a dual-layer stent structure. The thin-film covered stent device may have smaller pores and a high pore density compared to conventional stents. For example, the thin-film covered stent device may have a slit length of between 50 and 250 micrometers and a pore density of between 134 and 227 pores per mm2. The thin-film covered stent device facilitates rapid healing of tissue defects such as those encountered during the endovascular treatment of an aneurysm.Type: ApplicationFiled: April 30, 2021Publication date: August 19, 2021Inventors: Colin Kealey, Ian A. Cook, Vikas Gupta
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Patent number: 11020254Abstract: A thin-film covered stent device may include a thin-film mesh and a stent backbone covered by the thin-film mesh, thereby forming a dual-layer stent structure. The thin-film covered stent device may have smaller pores and a high pore density compared to conventional stents. For example, the thin-film covered stent device may have a slit length of between 50 and 250 micrometers and a pore density of between 134 and 227 pores per mm2. The thin-film covered stent device facilitates rapid healing of tissue defects such as those encountered during the endovascular treatment of an aneurysm.Type: GrantFiled: December 20, 2017Date of Patent: June 1, 2021Assignee: Monarch Biosciences, Inc.Inventors: Colin Kealey, Ian A. Cook, Vikas Gupta
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Patent number: 10932896Abstract: Methods and devices are provided for the use of thin-film cuffs on endovascular grafts. A method includes forming a fenestrated thin-film Nitinol sheet, expanding the fenestrated thin-film Nitinol sheet to expand the fenestrations, and attaching the expanded thin-film Nitinol sheet to a longitudinal end of a cover for an endovascular graft to form a cuff for the endovascular graft. The method may further include implanting the endovascular graft into a blood vessel. An endovascular graft may include a cover having a proximal and distal end, a proximal thin-film mesh cuff extending from the proximal end, and a distal thin-film mesh cuff extending form the distal end.Type: GrantFiled: May 25, 2017Date of Patent: March 2, 2021Assignee: Monarch Biosciences, Inc.Inventors: Ian A. Cook, Colin Kealey, Vikas Gupta
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Patent number: 10639468Abstract: The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: GrantFiled: July 14, 2017Date of Patent: May 5, 2020Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ian A. Cook, Christopher M. DeGiorgio
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Patent number: 10537729Abstract: Trigeminal nerves are stimulated based upon pulse counting and chronobiology. A cutaneous electrode assembly is applied to the forehead to stimulate the ophthalmic nerves. A method may include determining a number of pulses to be administered to a patient based upon the disorder being treated, and pulsing current through an electrode assembly to stimulate the patient's supraorbital and supratrochlear nerves with the determined number of pulses. Another method may include determining a pulse repetition frequency for pulses to be administered to a patient based upon the disorder being treated, and pulsing current through an electrode assembly to stimulate the patient's supraorbital and supratrochlear nerves at the pulse repetition frequency.Type: GrantFiled: May 19, 2017Date of Patent: January 21, 2020Assignee: NEUROSIGMA, INC.Inventors: Ian A. Cook, Colin Kealey
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Publication number: 20190269922Abstract: The present disclosure relates to methods, devices and systems used for the treatment of neurological disorders via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infratrochlear, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal, infraorbital, and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein. Systems and devices configured for therapeutic stimulation of the branches of the trigeminal nerves, such as the superficial trigeminal nerve, and their methods of application are also described.Type: ApplicationFiled: March 4, 2019Publication date: September 5, 2019Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC.Inventors: Christopher DeGiorgio, Ian A. Cook, Leon Ekchian
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Patent number: 10322283Abstract: The present disclosure relates to methods, devices and systems used for the treatment of mood, anxiety, post traumatic stress disorder, and cognitive and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: GrantFiled: May 25, 2017Date of Patent: June 18, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Christopher DeGiorgio, Ian A. Cook, Alejandro Covalin, Patrick R. Miller, Lara Schrader
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Patent number: 10238862Abstract: The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: GrantFiled: April 10, 2018Date of Patent: March 26, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ian A. Cook, Christopher M. DeGiorgio
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Patent number: 10195435Abstract: The present disclosure relates to methods, devices, and systems used for the treatment of mood, anxiety, cognitive, and behavioral disorders (collectively, neuropsychiatric disorders) via stimulation of the superficial elements of the trigeminal nerve (“TNS”). More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: GrantFiled: November 10, 2016Date of Patent: February 5, 2019Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC.Inventors: Christopher M. Degiorgio, Ian A. Cook, Leon Ekchian
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Publication number: 20180229029Abstract: The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: ApplicationFiled: April 10, 2018Publication date: August 16, 2018Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ian A. Cook, Christopher M. DeGiorgio
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Patent number: 10035013Abstract: An implantable subcutaneous electrode system is disclosed. The implantable subcutaneous electrode system may include an electrode body with electrical contacts disposed thereon or integrally formed therein. The electrode body also may include an insulation region defined between the electrical contacts and an aperture defined in the electrode body for receiving an anchoring device. A minimally invasive delivery device and methods for delivery of an implantable electrode system is also provided. The methods may include steps of introducing a needle comprising a cannula and a stylet through a patient's skin, removing the stylet while leaving the cannula in place, introducing an electrode applicator through the cannula, the electrode applicator comprising a hollow driver which receives the electrode assembly, and anchoring the electrode assembly to a bone by driving the hollow driver such that a self-tapping screw within the electrode assembly screws into the bone.Type: GrantFiled: April 5, 2013Date of Patent: July 31, 2018Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC.Inventors: Antonio A. F. Desalles, Alessandra Gorgulho, Christopher M. DeGiorgio, Ian A. Cook, Colin Kealey, Leon Ekchian, Patrick Miller
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Patent number: 10016601Abstract: A system for trigeminal nerve stimulation includes a pulse generator, which includes a user control configured to receive a user adjustment and a microcontroller configured to receive electric stimulation parameters and operate the pulse generator to produce electrical pulses according to the electric stimulation parameters during a treatment session. A method for nerve stimulation includes receiving, by a pulse generator, electric stimulation parameters, and producing, by the pulse generator, electrical pulses according to electric stimulation parameters during a treatment session. The electric stimulation parameters include at least one user-set parameter, which includes a current amplitude that is responsive to the user adjustment of the user control, and at least one physician-set parameter, which includes an upper bound and a lower bound for the current amplitude.Type: GrantFiled: May 20, 2016Date of Patent: July 10, 2018Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC.Inventors: Ian A. Cook, Christopher M. DeGiorgio, Leon Ekchian, Patrick Miller, Colin Kealey
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Publication number: 20180110637Abstract: A thin-film covered stent device may include a thin-film mesh and a stent backbone covered by the thin-film mesh, thereby forming a dual-layer stent structure. The thin-film covered stent device may have smaller pores and a high pore density compared to conventional stents. For example, the thin-film covered stent device may have a slit length of between 50 and 250 micrometers and a pore density of between 134 and 227 pores per mm2. The thin-film covered stent device facilitates rapid healing of tissue defects such as those encountered during the endovascular treatment of an aneurysm.Type: ApplicationFiled: December 20, 2017Publication date: April 26, 2018Inventors: Colin Kealey, Ian A. Cook, Vikas Gupta
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Publication number: 20180001077Abstract: The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, infraorbital, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: ApplicationFiled: July 14, 2017Publication date: January 4, 2018Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Ian A. Cook, Christopher M. DeGiorgio
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Publication number: 20170348521Abstract: The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and mentalis nerves (also referred to collectively as the superficial trigeminal nerve) are disclosed herein.Type: ApplicationFiled: June 15, 2017Publication date: December 7, 2017Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEUROSIGMA, INC., UNITED STATES GOVERNMENT DEPARTMENT OF VETERANS AFFAIRSInventors: Ian A. Cook, Christopher M. DeGiorgio, Leon Ekchian, Patrick Miller, Antonio De Salles
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Publication number: 20170265870Abstract: Thin-film mesh for medical devices, including stent and scaffold devices, and related methods are provided. Micropatterned thin-film mesh, such as thin-film Nitinol (TFN) mesh, may be fabricated via sputter deposition on a micropatterned wafer. The thin-film mesh may include slits to be expanded into pores, and the expanded thin-film mesh used as a cover for a stent device. The stent device may include two stent modules that may be implanted at a bifurcated aneurysm such that one module passes through a medial surface of the other module. The thin-film mesh may include pores with complex, fractal, or fractal-like shapes. The thin-film mesh may be used as a scaffold for a scaffold device. The thin-film scaffold may be placed in a solution including structural protein such as fibrin, seeded with cells, and placed in the body to replace or repair tissue.Type: ApplicationFiled: June 6, 2017Publication date: September 21, 2017Inventors: Colin Kealey, Ian A. Cook, Vikas Gupta