Abstract: The present invention relates to fluorescent dyes of formula (I), including salts thereof, and extracellular vesicles and cells labelled with the fluorescent dyes. The present invention also relates to methods, uses and kits thereof.

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, PCSK9, or a pharmaceutically acceptable salt, solvate, prodrug or polymorph thereof, and to compositions and formulations comprising such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I): wherein A, D and Q are described herein.

Abstract: A method of manufacturing a forming tool. The forming tool may include at least one die having a perimeter wall and a profile panel. At least a portion of the die may be manufactured using an additive manufacturing process. For instance, the profile panel may be manufactured using an additive manufacturing process or the profile panel and additional portions of the die, such as the perimeter wall, may be manufactured using an additive manufacturing process.

Abstract: The invention relates to the isolation or extraction of exosomes.

Abstract: The invention relates to the isolation or extraction of exosomes.

Abstract: The invention relates to the isolation or extraction of exosomes.

Abstract: The unique annual herbaceous Cannabis plant variety ‘Red KROSS02-BK’ is provided. The variety can be distinguished by its outstanding features as described.

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, PCSK9, or a pharmaceutically acceptable salt, solvate, prodrug or polymorph thereof, and to compositions and formulations comprising such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I): wherein A, D and Q are described herein.

Abstract: The invention relates to the isolation or extraction of exosomes.

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, PCSK9, or a pharmaceutically acceptable salt, solvate, prodrug or polymorph thereof, and to compositions and formulations comprising such compounds, and methods of using and making such compounds. Compounds include comprising of Formula (I): (I) wherein A, D and Q are described herein.

Abstract: The invention provides methods and compositions for the isolation or extraction of exosomes or microvesicles. The methods and compositions may involve providing a device including exosome-binding ligands in the form of anionic or electron-rich groups arranged on a substrate surface. The methods and compositions may involve providing a device including a substrate having a surface, with a plurality of polymers attached to the substrate and exosome-binding ligands in the form of anionic or electron-rich groups arranged on the plurality of polymers.

Abstract: The invention relates to the isolation or extraction of exosomes.

Abstract: A rail clamp comprising two clamp elements (30a, 30b) securable together in clamping arrangement about a railway rail, wherein at least one of the clamp elements (30a, 30b) can include sensor retaining means to hold a sensor to make measurements relating to the rail. A first of said two clamp elements (30b) has a clamp head to engage a fish plate (14b) or a web-side of a railway rail. A clamp foot (34b) engages the underside of a railway rail foot (13). A second of said two clamp elements (30a) having a clamp head to engage the opposite fish plate or web-side of a railway rail and a clamp foot (34a) to engage the underside of the clamp foot (34b) of the first clamp element (34b). The first and second clamp elements (30a, 30b) are secured together by a connector (35), optionally a bolt, to a railway rail.

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, PCSK9, or a pharmaceutically acceptable salt, solvate, prodrug or polymorph thereof, and to compositions and formulations comprising such compounds, and methods of using and making such compounds. Compounds include comprising of Formula (I): (I) wherein A, D and Q are described herein.

Abstract: The invention relates to the isolation or extraction of exosomes.

Abstract: A rail clamp comprising two clamp elements (30a, 30b) securable together in clamping arrangement about a railway rail, wherein at least one of the clamp elements (30a, 30b) can include sensor retaining means to hold a sensor to make measurements relating to the rail. A first of said two clamp elements (30b) has a clamp head to engage a fish plate (14b) or a web-side of a railway rail. A clamp foot (34b) engages the underside of a railway rail foot (13). A second of said two clamp elements (30a) having a clamp head to engage the opposite fish plate or web-side of a railway rail and a clamp foot (34a) to engage the underside of the clamp foot (34b) of the first clamp element (34b). The first and second clamp elements (30a, 30b) are secured together by a connector (35), optionally a bolt, to a railway rail.

Abstract: The present invention relates to anti-tropomyosin compounds, processes for their preparation, and methods for treating or preventing a proliferative disease, preferably cancer, using compounds of the invention.

Abstract: The present invention relates to anti-tropomyosin compounds, processes for their preparation, and methods for treating or preventing a proliferative disease, preferably cancer, using compounds of the invention.

Abstract: The present invention relates to anti-tropomyosin compounds, processes for their preparation, and methods for treating or preventing a disease or disorder, such as a proliferative disease (preferably cancer), using compounds of the invention.

Abstract: The unique annual herbaceous Cannabis plant variety ‘Red KROSS02-BK’ is provided. The variety can be distinguished by its outstanding features as described.