Patents by Inventor Ian A. Latham
Ian A. Latham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6515112Abstract: A 99mTc complex which contains the moiety Tc═NR, Tc—N═NY or Tc(—N═NY)2, and as a synthetic organic ligand which confers biological target-seeking properties on the technetium complex, where: R is an aryl group, a substituted or unsubstituted alkyl group or the group —NR1R2; Y is an aryl group or a substituted or unsubstituted alkyl group; R1 and R2 are H, aryl groups or substituted or unsubstituted aliphatic or cyclic alkyl groups, and are the same or different provided that both are not hydrogen; where at least one of the R or Y groups comprises an aryl group which chelates the 99mTc.Type: GrantFiled: October 15, 2001Date of Patent: February 4, 2003Assignee: Amersham PLCInventors: Colin M. Archer, Jonathan R. Dilworth, Panna Jobanputra, Ian A. Latham, Russell M. Thompson
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Publication number: 20020082398Abstract: A 99mTc complex which contains the moiety Tc═NR, Tc—N═NY or Tc(—N═NY)2, and as a synthetic organic ligand which confers biological target-seeking properties on the technetium complex,Type: ApplicationFiled: October 15, 2001Publication date: June 27, 2002Inventors: Colin M. Archer, Jonathan R. Dilworth, Panna Jobanputra, Ian A. Latham, Russell M. Thompson
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Patent number: 6329513Abstract: A 99mTc complex which contains the moiety Tc═NR, Tc—N═NY or Tc(—N═NY)2, and as a synthetic organic ligand which confers biological target-seeking properties on the technetium complex, where: R is an aryl group, a substituted or unsubstituted alkyl group or the group —NR1R2; Y is an aryl group or a substituted or unsubstituted alkyl group; R1 and R2 are H, aryl groups or substituted or unsubstituted aliphatic or cyclic alkyl groups, and are the same or different provided that both are not hydrogen; where at least one of the R or Y groups comprises an aryl group which chelates the 99mTc.Type: GrantFiled: May 11, 2000Date of Patent: December 11, 2001Assignee: Nycomed Amersham plcInventors: Colin M. Archer, Jonathan R. Dilworth, Panna Jobanputra, Ian A. Latham, Russell M. Thompson
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Patent number: 6124440Abstract: .sup.99m Tc complexes of formula L.sub.n Tc.dbd.NR, L.sub.n Tc--N.dbd.NY, or L.sub.n Tc--(N.dbd.NY).sub.2 wherein each L is independently a monodentate or multidentate ligand;Y is a substituted or unsubstituted aryl group or substituted or unsubstituted alkyl group;R is Y or the grouping --NR.sup.1 R.sup.2 ;n is 1-4;where at least one of R or Y is combined with one or more of the L groups; R.sup.1 and R.sup.2 are H, substituted or unsubstituted aryl groups or substituted or unsubstituted aliphatic or cyclic alkyl groups, and are the same or different, provided that both are not hydrogen.Type: GrantFiled: November 1, 1999Date of Patent: September 26, 2000Assignee: Nycomed Amersham plcInventors: Colin M. Archer, Jonathan R. Dilworth, Panna Jobanputra, Ian A. Latham, Russell M. Thompson
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Patent number: 6001979Abstract: A synth .sup.99m Tc complex which contains the moiety Tc.dbd.NR, Tc--N.dbd.NY or Tc(--N.dbd.NY).sub.2 and an organic ligand which confers biological target-seeking properties on the technetium complex, where R is an aryl group, a substituted or unsubstituted alkyl group or the group --NR.sup.1 R.sup.2 ; Y is an aryl group or a substituted or unsubstituted alkyl group; and R.sup.1 and R.sup.2 are H, aryl groups or substituted or unsubstituted aliphatic or cyclic alkyl groups, and are the same or different provided that both are not hydrogen. Radiopharmaceuticals comprising this complex are also described, together with methods for the preparation of the complex.Type: GrantFiled: December 24, 1996Date of Patent: December 14, 1999Assignee: Nycomed Amersham plcInventors: Colin M. Archer, Jonathan R. Dilworth, Panna Jobanputra, Ian A. Latham, Russell M. Thompson
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Patent number: 5589576Abstract: Novel complexes of technetium (.sup.99 Tc or .sup.99m Tc) which contain the moiety Tc.dbd.NR, Tc--N.dbd.NY or Tc(--N.dbd.NY).sub.2, and a ligand which confers biological target-seeking properties on the complex, wherein R represents an aryl group, a substituted or unsubstituted alkyl group, or the grouping .dbd.NR.sup.1 R.sup.2 ; Y represents an aryl group or a substituted or unsubstituted alkyl group; and R.sup.1 and R.sup.2 are hydrogen, aryl groups or substituted or unsubstituted aliphatic or cyclic alkyl groups, and may be both the same or different, provided that both are not hydrogen. The complexes are suitable for use in radiopharmaceuticals for a variety of clinical applications. Methods for the preparation of these technetium complexes are also described.Type: GrantFiled: August 12, 1994Date of Patent: December 31, 1996Assignee: Amersham International plcInventors: Colin M. Archer, Jonathan R. Dilworth, Panna Jobanputra, Ian A. Latham, Russell M. Thompson
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Patent number: 5081232Abstract: Complexes useful as radiopharmaceuticals contain the .sup.99m Tc-NO moiety and up to four organic ligands which confer biological target-seeking properties on the complex. Preferred are mono-cationic complexes, particularly having the formula[.sup.99m Tc(NO)L.sub.2 X].sup.+where X is halide or pseudohalide and L is a bidentate ligand for Technetium, which have interesting properties for use as heart visualizing agents. Examples of ligands include di-(dialkyl and diphenyl)phosphinoethanes and o-phenylenebisdimethylarsine. The complexes may be made by reacting generator eluate pertechnetate with a hydroxylamine salt and with the ligands, preferably in a single step by providing a reaction mixture containing the three reagents optionally in the presence of a reducing agent.Type: GrantFiled: May 16, 1988Date of Patent: January 14, 1992Assignee: Amersham International plcInventors: Ian A. Latham, John R. Thornback, Joanne L. Newman
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Patent number: 5045302Abstract: This invention concerns novel bidentate ligands L having two phosphorus or arsenic atoms. Cationic complexes of the ligands with Technetium-99m, e.g. having the formula [TcO.sub.2 L.sub.2 ].sup.+, are useful for body imaging, particularly myocardial imaging. The ligands have the general formulaY.sub.2 QZQY.sub.2where Q is phosphorus orZ is a --CC-- or --CCC-- or --COC-- groups,the four groups Y are all C1-C8 saturated hydrocarbon or fluorohydrocarbon with 1-3 ether oxygen atoms.Type: GrantFiled: March 28, 1989Date of Patent: September 3, 1991Assignee: Amersham International plcInventors: James D. Kelly, Kwok W. Chiu, Ian A. Latham
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Patent number: 4916214Abstract: The invention concerns cationic complexes of Technetium-99m with bidentate ligands (L), including complexes having the formulae [Tc(NO) X L.sub.2 ].sup.+ and [Tc L.sub.3 ].sup.+, which are of interest as heart imaging agents. The ligands are characterized by having the formula Y.sub.2 QZQY.sub.2, where each Q is phosphorus or arsenic, Z is a 2 or 3 carbon atom linking group, and at least one of the groups Y and Z includes at least one --COC--ether group.Type: GrantFiled: October 6, 1988Date of Patent: April 10, 1990Assignee: Amersham International plc.Inventors: Kwok W. Chiu, James D. Kelly, Ian A. Latham, David V. Griffiths, Peter G. Edwards