Abstract: The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

Abstract: The present invention provides novel engineered influenza hemagglutinin (HA) proteins, related polynucleotide sequences, and vaccine compositions including nanoparticle compositions. Relative to a wildtype HA protein, the engineered HA proteins are stabilized via substitutions of one or more conserved residues in the HA2 ectodomain with hydrophobic residues. The invention also provides methods of using such vaccine compositions in various therapeutic applications, e.g., for preventing or treating influenza viral infections.

Abstract: The present invention provides redesigned soluble coronavirus S protein derived immunogens that are stabilized via specific modifications in the wildtype soluble S sequences. Also provided in the invention are nanoparticle vaccines that contain the redesigned soluble S immunogens displayed on self-assembling nanoparticles. Polynucleotide sequences encoding the redesigned immunogens and the nanoparticle vaccines are also provided in the invention. The invention further provides methods of using the vaccine compositions in various therapeutic applications, e.g., for preventing or treating coronaviral infections.

Abstract: The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

Abstract: The present invention provides redesigned soluble coronavirus S protein derived immunogens that are stabilized via specific modifications in the wildtype soluble S sequences. Also provided in the invention are nanoparticle vaccines that contain the redesigned soluble S immunogens displayed on self-assembling nanoparticles. Polynucleotide sequences encoding the redesigned immunogens and the nanoparticle vaccines are also provided in the invention. The invention further provides methods of using the vaccine compositions in various therapeutic applications, e.g., for preventing or treating coronaviral infections.

Abstract: The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

Abstract: An example autonomous or remotely piloted aircraft includes a virtual aperture radar system including a plurality of antennas relationally positioned on one or more surfaces of the aircraft such that individual beams from each of the plurality of antennas scan respective volumes around the aircraft and the respective volumes together substantially form an ellipsoidal field of regard around the aircraft, and a computing device having one or more processors configured to execute instructions stored in memory for performing functions of: combining the respective volumes together to form an image representative of the ellipsoidal field of regard around the aircraft, and identifying one or more objects within the image.

Abstract: An example autonomous or remotely piloted aircraft includes a virtual aperture radar system including a plurality of antennas relationally positioned on one or more surfaces of the aircraft such that individual beams from each of the plurality of antennas scan respective volumes around the aircraft and the respective volumes together substantially form an ellipsoidal field of regard around the aircraft, and a computing device having one or more processors configured to execute instructions stored in memory for performing functions of: combining the respective volumes together to form an image representative of the ellipsoidal field of regard around the aircraft, and identifying one or more objects within the image.

Abstract: Disclosed are small molecule inhibitors of influenza HA, and methods of using them to treat or prevent HA-mediated diseases and conditions.

Abstract: The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

Abstract: The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to improve aircraft traffic control. An example apparatus includes a network interface to obtain air route traffic (ART) data associated with aircraft flying in airspace sectors during a first time period, a database controller to generate a first database entry by mapping extracted portions of the ART data to a first database entry field of the first database entry, and ART sector services to execute machine learning (ML) models using database entries to generate first aircraft traffic counts of the airspace sectors during the first time period, in response to selecting a first ML model of the ML models based on the first aircraft traffic counts, execute the first ML model to generate second aircraft traffic counts during a second time period, and transmit the second aircraft traffic counts to a computing device to cause an aircraft flight plan adjustment.

Abstract: The present invention provides redesigned soluble coronavirus S protein derived immunogens that are stabilized via specific modifications in the wildtype soluble S sequences. Also provided in the invention are nanoparticle vaccines that contain the redesigned soluble S immunogens displayed on self-assembling nanoparticles. Polynucleotide sequences encoding the redesigned immunogens and the nanoparticle vaccines are also provided in the invention. The invention further provides methods of using the vaccine compositions in various therapeutic applications, e.g., for preventing or treating coronaviral infections.

Abstract: A method, an apparatus, and a system for transmitting four-dimensional trajectories to an aircraft. Four-dimensional trajectory information for a four-dimensional trajectory for a flight of an aircraft is received. The four-dimensional trajectory information includes trajectory change points describing the four-dimensional trajectory. A subset of the trajectory change points that describe a shape of the four-dimensional trajectory is selected. A message containing the subset of the trajectory change points is created in a format used by an aircraft computer system in the aircraft. The message is transmitted to the aircraft computer system.

Abstract: Broadly neutralizing antibodies against HIV-1 which specifically bind to gp120 of HIV-1, a method of preparing such antibodies and the use thereof are provided.

Abstract: The present invention provides redesigned soluble coronavirus S protein derived immunogens that are stabilized via specific modifications in the wildtype soluble S sequences. Also provided in the invention are nanoparticle vaccines that contain the redesigned soluble S immunogens displayed on self-assembling nanoparticles. Polynucleotide sequences encoding the redesigned immunogens and the nanoparticle vaccines are also provided in the invention. The invention further provides methods of using the vaccine compositions in various therapeutic applications, e.g., for preventing or treating coronaviral infections.

Abstract: The present invention provides redesigned soluble coronavirus S protein derived immunogens that are stabilized via specific modifications in the wildtype soluble S sequences. Also provided in the invention are nanoparticle vaccines that contain the redesigned soluble S immunogens displayed on self-assembling nanoparticles. Polynucleotide sequences encoding the redesigned immunogens and the nanoparticle vaccines are also provided in the invention. The invention further provides methods of using the vaccine compositions in various therapeutic applications, e.g., for preventing or treating coronaviral infections.

Abstract: A method, an apparatus, and a system for transmitting four-dimensional trajectories to an aircraft. Four-dimensional trajectory information for a four-dimensional trajectory for a flight of an aircraft is received. The four-dimensional trajectory information includes trajectory change points describing the four-dimensional trajectory. A subset of the trajectory change points that describe a shape of the four-dimensional trajectory is selected. A message containing the subset of the trajectory change points is created in a format used by an aircraft computer system in the aircraft. The message is transmitted to the aircraft computer system.

Abstract: The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

Abstract: The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.