Abstract: The present disclosure relates to anti-HIV antibodies and their use in the treatment or prevention of HIV/AIDS and in the development of HIV vaccines.

Abstract: The present disclosure relates to methods for generating broadly neutralizing bovine anti-HIV Env antibodies, compositions comprising the broadly neutralizing bovine antibodies, and methods of treatment or prevention of HIV using the broadly neutralizing bovine antibodies. In certain embodiments, a broadly neutralizing bovine antibody comprises a polyclonal F(ab) or F(ab?)2 fragment. In certain embodiments, a broadly neutralizing bovine antibody comprises a humanized bovine monoclonal antibody.

Abstract: Provided are methods for prophylaxis or therapy for an RNA virus infection. The methods involve modulating the Type I interferon pathway in RNA virus infected cells of an individual. The Type I interferon pathway is modulated by administering one or more agents to virus infected cells that inhibit the expression and/or function of METTL3 or inhibit expression and/or function of YTHDF1, YTHDF2 or YTHDF3.

Abstract: The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

Abstract: The present invention provides novel engineered Ebolavirus GP proteins and polypeptides, scaffolded vaccine compositions that display the engineered proteins, and polynucleotides encoding the engineered proteins and scaffolded vaccine compositions. The invention also provides methods of using such engineered Ebolavirus GP proteins and vaccine compositions in various therapeutic applications, e.g., for preventing or treating Ebolavirus infections.

Abstract: The present invention provides redesigned soluble coronavirus S protein derived immunogens that are stabilized via specific modifications in the wildtype soluble S sequences. Also provided in the invention are nanoparticle vaccines that contain the redesigned soluble S immunogens displayed on self-assembling nanoparticles. Polynucleotide sequences encoding the redesigned immunogens and the nanoparticle vaccines are also provided in the invention. The invention further provides methods of using the vaccine compositions in various therapeutic applications, e.g., for preventing or treating coronaviral infections.

Abstract: A connector adapted for forming a fluid flow pathway therethrough by connection with a reciprocal connector, wherein both the connector and the reciprocal connector each comprise a fluid flow passageway part (11A) defining a fluid flow opening, a socket part (12A) located upon the fluid flow passageway part adjacent to the fluid flow opening, a plug part (13A) located upon the fluid flow passageway part adjacent to the fluid flow opening and spaced from the socket part in a direction crossing the fluid flow opening, wherein the socket part of the connector is configured to receive therein the plug part of said reciprocal connector to connect thereto such that the fluid flow opening of the connector is aligned in register with the fluid flow opening of the reciprocal connector and, a closure part (14A) arranged to openably close the fluid flow opening of the connector and to receive an urging force from said received plug part of the reciprocal connector thereby to be displaced in a direction crossing the flui

Abstract: The present disclosure relates to methods for generating broadly neutralizing bovine anti-HIV Env antibodies, compositions comprising the broadly neutralizing bovine antibodies, and methods of treatment or prevention of HIV using the broadly neutralizing bovine antibodies. In certain embodiments, a broadly neutralizing bovine antibody comprises a polyclonal F(ab) or F(ab?)2 fragment. In certain embodiments, a broadly neutralizing bovine antibody comprises a humanized bovine monoclonal antibody.

Abstract: There is provided a rotor for use in an tangential internal batch mixer, the rotor comprising a main body configured to rotate about a rotor axis, a wing extending from the main body, and arranged helically about a portion of the main body, the wing comprising a wing tip surface, a first portion of the wing tip surface extending between a first edge and a second edge of the wing, wherein the first edge comprises a first helix angle and the second edge comprises a second helix angle, the first helix angle being different to the second helix angle.

Abstract: The invention relates to an emergency lighting unit for supplying emergency lighting unit, comprising mains supply terminals, at least one first battery module comprising one or more cells in parallel, at least one second battery module comprising one or more cells and being connected in parallel to the at least one first battery module, a preferably common charging circuit for the first and second battery module and connected to the mains supply terminals, and an emergency driver circuit for supplying the emergency lighting unit off terminals of the emergency lighting unit, wherein the charging circuit is configured to charge and maintain the at least one second battery module to a charging voltage of maximum 50%, preferably maximum 30%, of a nominal charging voltage of the at least first battery module. (FIG.

Abstract: The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

Abstract: An example autonomous or remotely piloted aircraft includes a virtual aperture radar system including a plurality of antennas relationally positioned on one or more surfaces of the aircraft such that individual beams from each of the plurality of antennas scan respective volumes around the aircraft and the respective volumes together substantially form an ellipsoidal field of regard around the aircraft, and a computing device having one or more processors configured to execute instructions stored in memory for performing functions of: combining the respective volumes together to form an image representative of the ellipsoidal field of regard around the aircraft, and identifying one or more objects within the image.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. The proppant container is provided with a system for dislodging the wet sand for subsequent use. This may be done by use of a vibrator or an umbrella valve. In another aspect, the proppant container may be used in combination with a rack having a wash system that slurries the proppant for delivery to a blender tub without necessarily resorting to use of a conveyor belt.

Abstract: A connector for forming a fluid flow pathway by connection with a reciprocal connector. Both the connector and reciprocal connector include a fluid flow blockage part sheathed within an axially compressible sheath part. A first bearing surface receives an urging force to retract the blockage part axially along the sheath part. A terminal end of the sheath part defines a second bearing surface containing a fluid flow opening with the fluid flow blockage part retractably therein. A first chassis part includes a first catch part. A second chassis part includes a second catch part and a third bearing surface spaced from the second catch part along the second chassis part. Retraction of the blockage part forms a fluid flow pathway not sooner than immediately when the openings meet to allow fluid transfer the openings avoiding fluid leakage between connected connectors.

Abstract: An example autonomous or remotely piloted aircraft includes a virtual aperture radar system including a plurality of antennas relationally positioned on one or more surfaces of the aircraft such that individual beams from each of the plurality of antennas scan respective volumes around the aircraft and the respective volumes together substantially form an ellipsoidal field of regard around the aircraft, and a computing device having one or more processors configured to execute instructions stored in memory for performing functions of: combining the respective volumes together to form an image representative of the ellipsoidal field of regard around the aircraft, and identifying one or more objects within the image.

Abstract: A vehicle that can be modified for use in a variety of use environments and/or applications is provided. The vehicle includes a roof system includes a body and a roof system coupled to the body. The roof system includes a roof panel including a plurality of mounting points for the mounting of components and/or accessories. An interior cabin of the vehicle includes a front seating area, a rear seating area, and a cargo area. Divider panels may be secured in the vehicle to separate the front seating area, the rear seating area and the cargo area.

Abstract: A system of divider panels for a vehicle is provided. The system includes a first divider panel that separates a front seating area from a rear seating area of the vehicle. A second divider panel separates the rear seating area from a cargo area of the vehicle. A third divider panel separates the rear seating area into two separate areas. The first, second and third dividers may be removably coupled in the interior cabin of the vehicle by mounting points defined in the roof of the vehicle, the floor of the vehicle, and seating support structure of the vehicle.

Abstract: A roof system for a vehicle is provided. The roof system includes a roof panel including a plurality of mounting points. A plurality of components and/or accessories may be mounted to the roof system at the plurality of mounting points. A liner panel may be coupled to the roof panel, defining an interior facing side of the roof system. The liner panel may be coupled to the roof panel by a plurality of fasteners extending through the liner panel and into the roof panel from and interior facing side of the roof system. The liner panel may include a plurality of mounting points providing for the coupling or mounting of a plurality of accessories and/or components to the interior facing side of the roof system.

Abstract: Disclosed are small molecule inhibitors of influenza HA, and methods of using them to treat or prevent HA-mediated diseases and conditions.

Abstract: The present invention provides novel engineered HCV E2 polypeptide immunogens and related vaccine compositions that display the engineered E2 polypeptides. The invention also provides methods of using such immunogens and vaccine compositions in various therapeutic applications, e.g., for preventing or treating HCV infections.