Abstract: Broadly neutralizing antibodies against HIV-1 which specifically bind to gp120 of HIV-1, a method of preparing such antibodies and the use thereof are provided.

Abstract: The present invention provides redesigned soluble coronavirus S protein derived immunogens that are stabilized via specific modifications in the wildtype soluble S sequences. Also provided in the invention are nanoparticle vaccines that contain the redesigned soluble S immunogens displayed on self-assembling nanoparticles. Polynucleotide sequences encoding the redesigned immunogens and the nanoparticle vaccines are also provided in the invention. The invention further provides methods of using the vaccine compositions in various therapeutic applications, e.g., for preventing or treating coronaviral infections.

Abstract: The present invention provides novel engineered HCV E2 polypeptide immunogens and related vaccine compositions that display the engineered E2 polypeptides. The invention also provides methods of using such immunogens and vaccine compositions in various therapeutic applications, e.g., for preventing or treating HCV infections.

Abstract: The present invention provides redesigned soluble coronavirus S protein derived immunogens that are stabilized via specific modifications in the wildtype soluble S sequences. Also provided in the invention are nanoparticle vaccines that contain the redesigned soluble S immunogens displayed on self-assembling nanoparticles. Polynucleotide sequences encoding the redesigned immunogens and the nanoparticle vaccines are also provided in the invention. The invention further provides methods of using the vaccine compositions in various therapeutic applications, e.g., for preventing or treating coronaviral infections.

Abstract: An emergency unit (1) is provided, comprising input terminals (I1, I2) for supplying the emergency unit (1) with AC power, a battery charging unit (40) designed for charging a battery unit (30) of the emergency unit (1) by using the AC power, a DC/DC converter (10), supplied by the battery unit (30) and designed to provide DC power to DC power output terminals (O1, O2) designed for supplying power to emergency lighting means (EL), a control unit (20) designed for being supplied with a signal indicating the state of the AC power and for outputting commands to the battery charging unit (40) and to the DC/DC converter (10). The control unit (20) can assume a state (S6) in which it causes the DC/DC converter (10) to provide DC power based on the battery unit and at the same time start the operation of the battery charging unit (40).

Abstract: The invention proposes a lighting device, in particular an emergency lighting device. The lighting device includes a first housing (2), a lighting means (12), for example an LED arranged at the first housing (2) and an electronic circuitry accommodated in the first housing (2) for operating the lighting means (12). A second housing (3) of the lighting device accommodates an energy storage means (13) such as a rechargeable battery, wherein the first housing (2) and the second housing (3) are arranged spaced apart. An interconnecting means (4) mechanically connects the first housing (2) and the second housing (3) in an elastic manner and also connects electrically the electronic circuitry and the energy storage means (13). The interconnecting means (4) of the lighting device of a preferred embodiment comprises a cable which is overmoulded to provide compressive strength in an axial direction of the cable.

Abstract: A method, an apparatus, and a system for transmitting four-dimensional trajectories to an aircraft. Four-dimensional trajectory information for a four-dimensional trajectory for a flight of an aircraft is received. The four-dimensional trajectory information includes trajectory change points describing the four-dimensional trajectory. A subset of the trajectory change points that describe a shape of the four-dimensional trajectory is selected. A message containing the subset of the trajectory change points is created in a format used by an aircraft computer system in the aircraft. The message is transmitted to the aircraft computer system.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. The proppant container is part of an overall system that is used to move sand for use as proppant, and is fitted with a vibration system that facilitates the discharge of sand from the container.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. A metering conveyor is positioned between a blender tub and a proppant motive mechanism, such as a conveyor or wash system that receives discharge direct from proppant containers of the type normally used to transport sand in support of a hydraulic fracturing operation. The metering conveyor is fitted with sensors and/or a knife-edge gate that may be used to facilitate flow control operations.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. A metering conveyor is positioned between a blender tub and a proppant motive mechanism, such as a conveyor or wash system that receives discharge direct from proppant containers of the type normally used to transport sand in support of a hydraulic fracturing operation. The metering conveyor is fitted with equipment including an intermediate surge hopper with a vibration system and a knife-edge gate that may be used to facilitate the operational movement of sand.

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. A metering conveyor is positioned between a blender tub and a proppant motive mechanism, such as a conveyor or wash system that receives discharge direct from proppant containers of the type normally used to transport sand in support of a hydraulic fracturing operation. The metering conveyor is fitted with equipment including a knife-edge gate that may be used to facilitate flow control operations.

Abstract: The present disclosure relates to methods for generating broadly neutralizing bovine anti-HIV Env antibodies, compositions comprising the broadly neutralizing bovine antibodies, and methods of treatment or prevention of HIV using the broadly neutralizing bovine antibodies. In certain embodiments, a broadly neutralizing bovine antibody comprises a polyclonal F(ab) or F(ab?)2 fragment. In certain embodiments, a broadly neutralizing bovine antibody comprises a humanized bovine monoclonal antibody.

Abstract: The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

Abstract: Techniques for layout-agnostic complex document processing are described. A document processing service can analyze documents that do not adhere to defined layout rules in an automated manner to determine the content and meaning of a variety of types of segments within the documents. The service may chunk a document into multiple chunks, and operate upon the chunks in parallel by identifying segments within each chunk, classifying the segments into segment types, and processing the segments using special-purpose analysis engines adapted for the analysis of particular segment types to generate results that can be aggregated into an overall output for the entire document that captures the meaning and context of the document text.

Abstract: The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.

Abstract: An emergency unit (1) is provided, comprising input terminals (I1, I2) for supplying the emergency unit (1) with AC power, a battery charging unit (40) designed for charging a battery unit (30) of the emergency unit (1) by using the AC power, a DC/DC converter (10), supplied by the battery unit (30) and designed to provide DC power to DC power output terminals (O1, O2) designed for supplying power to emergency lighting means (EL), a control unit (20) designed for being supplied with a signal indicating the state of the AC power and for outputting commands to the battery charging unit (40) and to the DC/DC converter (10). The control unit (20) can assume a state (S6) in which it causes the DC/DC converter (10) to provide DC power based on the battery unit and at the same time start the operation of the battery charging unit (40).

Abstract: A proppant container facilitates the transportation of wet sand for use in a hydraulic fracturing operation. The proppant container is provided with a system for dislodging the wet sand for subsequent use. This may be done by use of a vibrator or an umbrella valve. In another aspect, the proppant container may be used in combination with a rack having a wash system that slurries the proppant for delivery to a blender tub without necessarily resorting to use of a conveyor belt.

Abstract: The invention is in the field of emergency lighting devices and power supply of emergency lighting devices. A LED converter for an emergency lighting unit comprises a LED driver for supplying a current to a LED lighting device, an energy storage interface for connecting an energy storage device, a charging circuit for charging the energy storage, and a control circuit. The energy storage interface is configured to connect at least two different types of energy storage devices. The charging circuit sets at least one energy storage management parameter according to the type of energy storage device connected by the energy storage interface. The control circuit determines the type of energy storage device connected by the energy storage interface and controls the charging circuit to set the energy storage management parameter according to the determined type of energy storage device.

Abstract: The invention provides methods for identifying protein modulators (e.g., antibody agonists) of eukaryotic cells. The methods typically involve expressing a combinatorial agent library (e.g., via lentiviral vectors) inside a eukaryotic cell type (e.g., a mammalian cell) and then directly selecting for agents (e.g., antibodies) that are agonist of a target molecule (e.g., a signaling receptor) that modulates a phenotype of or elicits a cellular response in the cell. Some related methods involve co-culturing a cell expressing a combinatorial agent library and a second cell, and then selecting agents that modulate a phenotype of or elicit a cellular response in the second cell. Preferably, the agents are antibodies and are introduced into and expressed in the starting cells under conditions each individual cell expresses no more than 3 different members of the antibody library.

Abstract: An emergency operating arrangement for at least one building technical device is provided, comprising a power supply unit, and an emergency supply unit, the power supply unit and the emergency supply unit being adapted to be supplied by an electrical supply and being configured to output a DC voltage, wherein the emergency supply unit is configured to detect an emergency situation and being configured to output a DC voltage higher than the DC voltage output by the power supply unit when the emergency situation is detected.