Abstract: A valved container assembly which has a container for containing a fluid, the container extending in an axial direction and having an open front end and a valve disposed in the container. The valved container assembly is configured so that forward axial movement of the valve relative to the container is inhibited. A plunger element is disposed axially rearward of the valve and is axially moveable in the container. The plunger element is configured to increase the pressure of a fluid in a first volume of the container upon forward axial movement relative to the valve. The valve includes a channel bypassing the permanent seal, the channel having a first opening in fluid communication with the atmosphere outside of the valved container assembly and a second opening selectively sealed from the first volume by a resilient seal.

Abstract: A server system sorts a plurality of sessions for multiple users of a media-providing service into a plurality of groups by applying one or more sorting rules to one or more session characteristics for the plurality of sessions. The server system divides respective groups of the plurality of groups into respective pluralities of clusters using a machine-learning algorithm. The server system tracks user interaction with a client device during a user session and identifies the user session as belonging to a first cluster of the pluralities of clusters based at least in part on the user interaction. In accordance with identifying that the user session belongs to the first cluster, the server system personalizes content for the user session using one or more content criteria associated with the first cluster.

Abstract: A valve for discharging a fluid, comprising: a valve body at least partially defining a fluid chamber; and a valve stem extending into the fluid chamber, the valve stem comprising an outlet port for transfer, in use, of fluid from the fluid chamber into the valve stem; the valve stem being slidably movable relative to the valve body from: i) a non-dispensing position in which the outlet port is out of communication with the fluid chamber; to ii) a dispensing position in which the outlet port is in fluid communication with the fluid chamber so as to permit transfer of the fluid from the fluid chamber into the valve stem; wherein the valve further comprises a locking member which is configured to prevent return of the valve stem into the non-dispensing position once the valve stem slides beyond a locking position.

Abstract: A sub-assembly of a medicament delivery device including a propellant source having a reservoir for containing a propellant and a stem for dispensing propellant from the reservoir, the stem extending axially along a longitudinal axis and having an open outlet end and a bore therethrough that is in fluid communication with the open outlet end and is selectively in fluid communication with the reservoir. The sub-assembly also includes a spray head member attachable to the stem. The spray head member is arranged to radially deflect propellent passing through the bore of the stem relative to the longitudinal axis.

Abstract: A syringe assembly comprising a barrel for containing one or more medicaments, the barrel having a front outlet for allowing the expulsion of said one or more medicaments from the said barrel through said outlet, and a first stopper disposed in the barrel and axially moveable therein and defining a first volume in the barrel axially forwards of the first stopper and a second volume in the barrel axially rearwards of the first stopper. The first stopper has a two way valve that is moveable between a sealing configuration and an open configuration to selectively put the first volume in fluid communication with the second volume. The two way valve is moveable from the sealing configuration to the open configuration by an increase in fluid pressure in either of the first and second volumes.

Abstract: A medicament delivery device comprising a first container having a delivery outlet at a front end thereof and a first stopper axially moveable in the first container, the first stopper defining and separating a first chamber and a second chamber in the first container, where the first chamber is axially forwards of the first stopper and the second chamber is axially rearwards of the first stopper. The medicament delivery device further comprising a second container having a second stopper axially moveable in the second container, the second stopper defining and separating a third chamber and a fourth chamber in the second container, where the third chamber is axially forwards of the second stopper and the fourth chamber is axially rearwards of the second stopper, and where the third chamber has a vent outlet in fluid communication with a venting chamber.

Abstract: A fluid injection device (18) for controlling injection of fluid into an oil-carrying tube in an oil well includes an inlet (20) for receiving the fluid; an outlet (28) for supplying the fluid for injection into the oil-carrying tube; an inlet valve (22) in a fluid path between the inlet and the outlet; an actuator (24) for opening and closing the valve; and a connector (36) for coupling the inlet to a fluid supply tube (32) extending between the device and a source of the fluid above the ground. A method of controlling injection of fluid using such a device is also provided.

Abstract: An assembly for an auto injector device, the assembly including a syringe support for supporting a syringe by limiting forward axial movement of the syringe relative to the syringe support, and a guard element attachable to the syringe support by an attachment so that the guard element is axially restrained both axially forwardly and axially rearwardly relative to the syringe support by the attachment. Forwardly directed axial loads received by the guard element are transmitted to the syringe support via the attachment.

Abstract: A valve for discharging a fluid, comprising: a valve body at least partially defining a fluid chamber; and a valve stem extending into the fluid chamber, the valve stem comprising an outlet port for transfer, in use, of fluid from the fluid chamber into the valve stem; the valve stem being slidably movable relative to the valve body from: i) a non-dispensing position in which the outlet port is out of communication with the fluid chamber; to ii) a dispensing position in which the outlet port is in fluid communication with the fluid chamber so as to permit transfer of the fluid from the fluid chamber into the valve stem; wherein the valve further comprises a locking member which is configured to prevent return of the valve stem into the non-dispensing position once the valve stem slides beyond a locking position.

Abstract: A method of manufacturing a container containing propellant includes i) sealing a first sheet of rupturable material to a second sheet of rupturable material to form a lower seal and two side seals; ii) placing a propellant dispensing apparatus in fluid communication with a central volume defined by said lower seal, the two side seals and a seal between the propellant dispensing apparatus and the first and second sheets; iii) depositing propellant in the central volume using the propellant dispensing apparatus; and iv) sealing the first sheet to the second sheet to form an upper seal to form a container where the propellant is contained between the upper seal, the lower seal, and the two side seals.

Abstract: A method of manufacturing a container containing propellant includes i) sealing a first sheet of rupturable material to a second sheet of rupturable material to form a lower seal and two side seals; ii) placing a propellant dispensing apparatus in fluid communication with a central volume defined by said lower seal, the two side seals and a seal between the propellant dispensing apparatus and the first and second sheets; iii) depositing propellant in the central volume using the propellant dispensing apparatus; and iv) sealing the first sheet to the second sheet to form an upper seal to form a container where the propellant is contained between the upper seal, the lower seal, and the two side seals.

Abstract: A syringe propellable by propellant that boils at a predetermined temperature, the syringe including a barrel having an outlet at a front end, and a stopper axially moveable in the barrel. The stopper separates a first chamber and a second chamber, the first chamber being axially forwards of the stopper and being configured for containing a medicament, and the second chamber being axially rearwards of the stopper and being configured to receive propellant for acting on the stopper to move the stopper axially forwardly in the barrel to expel medicament through the outlet upon actuation of the syringe. The syringe further includes a third chamber for containing propellant. Upon actuation of the syringe, liquid propellant is released from the third chamber and boils outside of the third chamber at or above the predetermined temperature to provide an increasing vapor pressure in the second chamber that causes the stopper to move axially forwardly and begin to expel medicament through the outlet.

Abstract: A valved container assembly (10) comprising a container (12) for containing a fluid, the container (12) extending in an axial direction and having at least one venting opening (12a) at a front end and at least one dispensing opening (12b). The valved container assembly (10) further comprising a valve (14) disposed in the container (12) and a plunger element (20) disposed axially rearward of the valve (14), the plunger element (20) being axially moveable in the container (12) and defining a first volume (22) in the container (12) between the plunger element (20) and the valve (14), where the plunger element (20) is configured to increase the pressure of a fluid in the first volume (22) upon axial movement relative to the valve (14).

Abstract: A syringe propellable by propellant that boils at a predetermined temperature, the syringe including a barrel having an outlet at a front end, and a stopper axially moveable in the barrel. The stopper separates a first chamber and a second chamber, the first chamber being axially forwards of the stopper and being configured for containing a medicament, and the second chamber being axially rearwards of the stopper and being configured to receive propellant for acting on the stopper to move the stopper axially forwardly in the barrel to expel medicament through the outlet upon actuation of the syringe. The syringe further includes a rupturing portion and a third chamber for containing propellant where the third chamber is rupturable upon actuation of the syringe to fluidly connect the third chamber to the second chamber.

Abstract: A valved container assembly which has a container for containing a fluid, the container extending in an axial direction and having an open front end and a valve disposed in the container. The valved container assembly is configured so that forward axial movement of the valve relative to the container is inhibited. A plunger element is disposed axially rearward of the valve and is axially moveable in the container. The plunger element is configured to increase the pressure of a fluid in a first volume of the container upon forward axial movement relative to the valve. The valve includes a channel bypassing the permanent seal, the channel having a first opening in fluid communication with the atmosphere outside of the valved container assembly and a second opening selectively sealed from the first volume by a resilient seal.

Abstract: A syringe assembly which has a barrel for containing one or more medicaments and a stopper disposed in the barrel defining and separating a first volume and a second volume within the syringe assembly. The stopper includes a permanent seal fluidly sealing the stopper to the barrel about the entire perimeter of the stopper intermediate the first volume and second volume, and a channel bypassing the permanent seal, the channel having a first opening in fluid communication with the second volume and a second opening selectively sealed from the first volume by a resilient seal. The resilient seal is moveable between a sealing configuration and an open configuration to selectively seal the channel from the first volume and is moveable from the sealing configuration to the open configuration upon fluid pressure in the first volume or second volume exceeding a first pressure threshold.

Abstract: An aqueous composition for treatment of water comprising: (a) an N,N-dimethyl-2-hydroxypropylammonium chloride polymer; (b) lanthanum chloride; and (c) a dimethylamine epichlorohydrin ethylenediamine polymer; and a method of treating water using the composition.

Abstract: An aqueous composition for treatment of water comprising: (a) an N,N-dimethyl-2-hydroxypropylammonium chloride polymer; (b) lanthanum chloride; and (c) a dimethylamine epichlorohydrin ethylenediamine polymer; and a method of treating water using the composition.

Abstract: Provided are anti-PAI-1 antibodies or antibody fragments and methods of using them.