Patents by Inventor Ian Anthony Cliffe

Ian Anthony Cliffe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090137623
    Abstract: The present invention relates to muscarinic receptor modulators, specifically, 7-oxo-2-azabicyclo[2.2.1]heptanes of formula (I) which are useful for the treatment of various diseases and conditions, for example, Alzheimer's disease, glaucoma, psychosis, particularly schizophrenia or schizophreniform conditions, mania, pain, bipolar disorder, depression, sleeping disorders, epilepsy, gastrointestinal motility disorders, urinary incontinence, and cognition enhancement.
    Type: Application
    Filed: January 2, 2007
    Publication date: May 28, 2009
    Inventors: Naresh Kumar, Ian Anthony Cliffe, Mohammad Salman, Venkata P. Palle, Kirandeep Kaur, Yogesh D. Shejul, Anita Chugh, Suman Gupta, Abhijit Ray, Shivani Malhotra, Raj Kumar Shirumalla
  • Patent number: 6831078
    Abstract: A compound of formula (1) wherein R1 is aryl; and R2 is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and their use in therapy, particularly for the treatment and prophylaxis of CNS disorders such as anxiety and epilepsy.
    Type: Grant
    Filed: February 12, 2001
    Date of Patent: December 14, 2004
    Assignee: Vernalis Research Limited
    Inventors: David Reginald Adams, Jon Bentley, Corinna Dagmar Bodkin, Ian Anthony Cliffe, James Edward Paul Davidson, Howard Langham Mansell, Nathaniel Julius Monck, Robin Gerald Shepherd, by Joy Miriam Shepherd
  • Patent number: 6706750
    Abstract: A chemical compound of formula (I) wherein: R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4, R6 and R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsufoxyl, alkylsulfonyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; R5 is selected from hydrogen, halogen, hydroxy, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, alkylsulfonyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; A is a 5- or 6-membered partially unsaturated or aromatic heterocyclic ring or a 5- or 6-membered partially unsaturated carbocyclic ring, wherein if A is a 6-membered partially unsaturated carbocyclic ring then at least one of R4 to R7 is other than hydrogen, and pharmaceutically acceptable salts, addition compounds and prodrugs thereof, and the use thereof in therapy, particularly as an agonist or antagonist of a 5HT receptor, particularly a 5HT
    Type: Grant
    Filed: March 11, 2002
    Date of Patent: March 16, 2004
    Assignee: Vernalis Research Limited
    Inventors: Jonathan Mark Bentley, Jonathan Richard Anthony Roffey, James Edward Paul Davidson, Howard Langham Mansell, Richard John Hamlyn, Ian Anthony Cliffe, David Reginald Adams, Nathaniel Julius Monck
  • Patent number: 6608085
    Abstract: Use of a compound of formula (I) as defined herein, or a pharmaceutically acceptable salt or prodrug thereof, in the manufacture of a medicament for the treatment or prevention of a disorder in which the blocking of purine receptors, particularly adenosine receptors and more particularly A2a receptors, may be beneficial, such as a movement disorder, for example, Parkinson's Disease or progressive supemuclear palsy, Huntingtons disease, multiple system atrophy, corticobasal degeneration, Wilsons disease, Hallerrorder-Spatz disease, progressive pallidal atrophy, Dopa-responsive dystonia-Parkinsonism, spasticity, Alzheimer's disease or other disorders of the basal ganglia which result in dyskinesias.
    Type: Grant
    Filed: May 9, 2001
    Date of Patent: August 19, 2003
    Assignee: Vernalis Research Limited
    Inventors: Roger John Gillespie, Joanne Lerpiniere, Paul Richard Giles, David Reginald Adams, Lars Jacob Stray Knutsen, Ian Anthony Cliffe
  • Patent number: 6514961
    Abstract: A compound of formula (1): wherein R1 is aryl; and R2, R3, R4, R5 and R6 which may be the same or different are selected from H, alkyl and aryl; pharmaceutically acceptable addition compounds thereof and the use of the compounds in therapy, particularly for CNS disorders such as anxiety and epilepsy.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: February 4, 2003
    Assignee: Vernalis Research Limited
    Inventors: David Reginald Adams, Ian Anthony Cliffe, Howard Langham Mansell, Nathaniel Julius Monck
  • Patent number: 6433175
    Abstract: A chemical compound of formula (I), wherein n is 1, 2 or 3; R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 to R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, alkylsulfoxyl, alkylsulfonyl, arylsulfoxyl, arylsulfonyl, amino, monoalkylamino, dialkylamino, nitro, cyano, carboxaldehyde, alkylcarbonyl, arylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino and dialkylaminocarbonylamino, or R5 and R6 together form a carbocyclic or heterocyclic ring, and pharmaceutically acceptable salts and prodrugs thereof, and the use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders, diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: August 13, 2002
    Assignee: Vernalis Research Limited
    Inventors: David Reginald Adams, Jonathan Mark Bentley, Jonathan Richard Anthony Roffey, Richard John Hamlyn, Suneel Gaur, Matthew Alexander James Duncton, James Edward Paul Davidson, Michael John Bickerdike, Ian Anthony Cliffe, Howard Langham Mansell
  • Patent number: 6403574
    Abstract: A compound of formula (1), wherein: R1 is aryl; R2 is H, alkyl or aryl; and R3 is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and the use of the compounds in therapy, particularly for the treatment and prophylaxis of CNS disorders such as anxiety and epilepsy.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: June 11, 2002
    Assignee: Vernalis Research Limited
    Inventors: David Reginald Adams, Corinna Dagmar Bodkin, Ian Anthony Cliffe, Howard Langham Mansell, Nathaniel Julius Monck, Robin Gerald Shepherd
  • Patent number: 6365598
    Abstract: A chemical compound of formula (I), wherein R1 to R3 are independently selected from hydrogen and alkyl; R4 is selected from hydrogen, alkyl, alkoxy, formyl and cyano; X1 is selected from N and C—R7; X2 is selected from N and C—R8; X3 is selected from N and C—R9; X4 is selected from N and C—R10; wherein at least one of X1, X2, X3 and X4 is N; and R5 to R10 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, alkylsulfoxyl, alkylsulfonyl, arylsulfoxyl, arylsulfonyl, amino, monoalkylamino, dialkylamino, nitro, cyano, carboxaldehyde, alkylcarbonyl, arylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino and dialkylaminocarbonylamino, and the use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; card
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: April 2, 2002
    Assignee: Vernalis Research Limited
    Inventors: David Reginald Adams, Jonathan Mark Bentley, Jonathan Richard Anthony Roffey, Corinna Dagmar Bodkin, Howard Langham Mansell, Ashley Roger George, Ian Anthony Cliffe
  • Patent number: 6127357
    Abstract: Piperazine derivatives of formula I ##STR1## and their pharmaceutically acceptable acid addition salts are 5-HT.sub.1A binding agents, particularly 5-HT.sub.1A antagonists and may be used, for example, as anxiolytics. In the formula A is C.sub.2-4 alkylene chain optionally substituted by lower alkyl, Z is oxygen or sulphur, R is hydrogen or lower alkyl, R.sup.1 is a mono or bicyclic aryl or heteroaryl radical, R.sup.2 is a mono or bicyclic heteroaryl radical and R.sup.3 is hydrogen or a specified radical such as lower alkyl, cycloalkyl, aryl, heteroaryl or optionally substituted amino.
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: October 3, 2000
    Assignee: John Wyeth & Brother, Ltd.
    Inventors: Ian Anthony Cliffe, Howard Langham Mansell
  • Patent number: 6056942
    Abstract: Selective 5-HT.sub.1A antagonists radiolabelled with .sup.3 H or .sup.11 C are radiolabelled ligands useful, for example, in pharmacological screening procedures and in positron emission tomography (PET) studies.
    Type: Grant
    Filed: August 18, 1997
    Date of Patent: May 2, 2000
    Assignee: John Wyeth & Brother, Ltd.
    Inventors: Ian Anthony Cliffe, Allan Fletcher, Alan Chapman White
  • Patent number: 5827847
    Abstract: Piperazine derivatives of formula (I) are useful in the treatment of cognitive disorders. In formula (I), X is a group of (IIa): --(CH.sub.2).sub.n CR.sup.2 R.sup.3 CONR.sup.4 R.sup.5 or (IIIb): --A--NR.sup.6 COR.sup.7 where n, A, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 have specified meanings.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: October 27, 1998
    Assignee: John Wyeth & Brother, Ltd.
    Inventors: Ian Anthony Cliffe, Allan Fletcher, Alan Chapman White
  • Patent number: 5763460
    Abstract: Compounds of formula (I) and the pharmaceutically acceptable acid addition salts thereof are 5-HT.sub.1A binding agents and may be used, for example, as anxiolytics. In the formula a and b each represents 0, 1, 2 or 3 such that the sum of a+b is 0, 1, 2 or 3, the dotted line represents an optional double bond which may be present in the ring, provided that a is at least 1, A is an alkylene chain of 1 or 2 carbon atoms optionally substituted by one or more lower alkyl groups, R is a mono or bicyclic aryl or heteroaryl radical with the proviso that R is not an unsubstituted phenyl group, R.sup.1 is a mono or bicyclic heteroaryl radical, and R.sup.2 is cycloalkyl or cycloalkenyl.
    Type: Grant
    Filed: January 16, 1996
    Date of Patent: June 9, 1998
    Assignees: John Wyeth & Brother Limited, American Home Products Corporation
    Inventors: Ian Anthony Cliffe, Terence James Ward, Chapman White Alan, Antony Ashwell Mark, Bernhard Baudy Reinhardt
  • Patent number: 5710149
    Abstract: This invention concerns compounds of formula (I) ##STR1## where A is a C.sub.1 or C.sub.2 alkylene chain optionally substituted by lower alkyl; Z is a bicyclic oxygen-containing aryl radical (e.g. 2,3-dihydro-1,4-benzodioxin-5-yl); R is hydrogen or lower alkyl; R.sup.1 is aryl or aryl(lower)alkyl; R.sup.2 is hydrogen or lower alkyl; and R.sup.3 is hydrogen, an alkyl group of 1 to 10 carbon atoms, cycloalkyl of 3 to 12 carbon atoms; cycloalkyl(lower)alkyl, aryl or aryl(lower)alkyl or R.sup.2 and R.sup.3 together with the nitrogen atom to which they are both attached represent a saturated heterocyclic ring which may contain a further hetero atom, and the pharmaceutically acceptable acid addition salts thereof. The compounds are 5-HT.sub.1A -antagonists which may be used, for example, in treating anxiety.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: January 20, 1998
    Assignee: John Wyeth & Brother, Ltd.
    Inventor: Ian Anthony Cliffe
  • Patent number: 5693642
    Abstract: Piperazine derivatives of formula (I) and their salts are 5-HT.sub.1A binding agents and may be used, for example, as anxiolytics. In the formula, R, R.sup.2 and R.sup.4 are hydrogen or lower alkyl, R.sup.1 is mono- or bicyclic aryl or heteroaryl, R.sup.3 is lower alkyl or cycloalkyl, A is an alkylene chain and X is --CO--. --CR.sup.5 OH-- (where R.sup.5 is hydrogen, lower alkyl or cycloalkyl), --S--, --SO-- or --SO.sub.2 -- or X can also be --(CH.sub.2).sub.n -- (where n is 0, 1 or 2) when R.sup.3 is cycloalkyl.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: December 2, 1997
    Assignee: John Wyeth & Brother Ltd.
    Inventors: Ian Anthony Cliffe, Mark Antony Ashwell, Terence James Ward, Alan Chapman White, Graham John Warrellow