Patents by Inventor Ian Bass Seiple
Ian Bass Seiple has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11634449Abstract: Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.Type: GrantFiled: December 4, 2020Date of Patent: April 25, 2023Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
-
Publication number: 20230109357Abstract: Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macrocyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.Type: ApplicationFiled: July 25, 2022Publication date: April 6, 2023Applicant: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
-
Patent number: 11535643Abstract: Provided herein are macrolide compounds of Formula (I) and (I-N) for the treatment of infectious diseases and inflammatory conditions. The 14-membered ketolides and 14-, 15-, and 16-membered azaketolides described herein comprise modified sugars which are desosamine or mycaminose analogs. Pharmaceutical compositions and methods of treating infection diseases and inflammatory conditions using the inventive macrolides are also provided. This disclosure additionally provides methods of preparing the macrolides by the coupling of an eastern and western half.Type: GrantFiled: April 8, 2020Date of Patent: December 27, 2022Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
-
Publication number: 20220332747Abstract: Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.Type: ApplicationFiled: December 4, 2020Publication date: October 20, 2022Applicant: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
-
Patent number: 11466046Abstract: Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macrocyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.Type: GrantFiled: April 8, 2020Date of Patent: October 11, 2022Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
-
Patent number: 10913764Abstract: Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.Type: GrantFiled: April 5, 2018Date of Patent: February 9, 2021Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
-
Publication number: 20200377542Abstract: Provided herein are macrolide compounds of Formula (I) and (I-N) for the treatment of infectious diseases and inflammatory conditions. The 14-membered ketolides and 14-, 15-, and 16-membered azaketolides described herein comprise modified sugars which are desosamine or mycaminose analogs. Pharmaceutical compositions and methods of treating infection diseases and inflammatory conditions using the inventive macrolides are also provided. This disclosure additionally provides methods of preparing the macrolides by the coupling of an eastern and western half.Type: ApplicationFiled: April 8, 2020Publication date: December 3, 2020Applicant: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
-
Publication number: 20200361980Abstract: Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macrocyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.Type: ApplicationFiled: April 8, 2020Publication date: November 19, 2020Applicant: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
-
Patent number: 10640528Abstract: Provided herein are macrolide compounds of Formula (I) and (I-N) for the treatment of infectious diseases and inflammatory conditions. The 14-membered ketolides and 14-, 15-, and 16-membered azaketolides described herein comprise modified sugars which are desosamine or mycaminose analogs. Pharmaceutical compositions and methods of treating infection diseases and inflammatory conditions using the inventive macrolides are also provided. This disclosure additionally provides methods of preparing the macrolides by the coupling of an eastern and western half.Type: GrantFiled: March 25, 2016Date of Patent: May 5, 2020Assignee: President and Fellows of Havard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
-
Patent number: 10633407Abstract: Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macro-cyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.Type: GrantFiled: October 8, 2015Date of Patent: April 28, 2020Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
-
Publication number: 20180298048Abstract: Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.Type: ApplicationFiled: April 5, 2018Publication date: October 18, 2018Applicant: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
-
Patent number: 9982005Abstract: Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.Type: GrantFiled: April 4, 2014Date of Patent: May 29, 2018Assignee: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
-
Publication number: 20170305953Abstract: Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macro-cyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.Type: ApplicationFiled: October 8, 2015Publication date: October 26, 2017Applicant: President and Fellows of Harvard CollegeInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
-
Publication number: 20160052951Abstract: Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.Type: ApplicationFiled: April 4, 2014Publication date: February 25, 2016Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang