Abstract: The invention provides a hair treatment composition such as a shampoo or conditioner comprising a disaccharide, alkali metal salt and a di-acid or salt thereof. Use of said composition for smoothing and aligning hair, for preventive damage to the hair.

Abstract: The present invention is directed to compounds of Formula (I): (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Abstract: The present invention is directed to compounds of Formula (I): where variables A1, A2, B, J, K, m, n, R4, R5a, R5a, R5c and X are as defined herein useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Abstract: The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Abstract: An apparatus and method are provided for easily indicating to a user that a communication has been received for him or her. A portable message waiting indication device (MWID) includes a power source (e.g., battery), signal receiver and a visual and/or audible indicator. The indicator is activated in response to receipt of a first wireless signal at the receiver. In response to a second signal the indicator is deactivated. A MWID may also include a user-actuable switch or sensor to deactivate the indicator. In one method of using a MWID to inform a user that a communication has been received, the user registers the MWID and may identify when the MWID indicator should be activated (e.g., for certain types of messages (e.g., voice-mail, electronic mail), certain senders, a category of senders, time of day, message priority). Multiple MWIDs may be configured and employed by a user, and each may be configured similarly or differently.

Abstract: The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Abstract: An internal combustion engine crankcase lubricating oil composition has a phosphorus content of not greater than 0.08 mass % and a metal detergent additive system comprising a calcium salicylate and a magnesium salicylate and having a mass ratio of magnesium atoms to calcium atoms of greater than one.

Abstract: The present invention is directed to compounds of the formula: that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Abstract: The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Abstract: When the mode change knob of a multi-mode hammer drill is moved to the hammer only position, an electronic sensor sends a signal to a control logic circuit. When the user then depresses the trigger mechanically closing the ON/OFF switch, the control logic circuit applies a voltage either to a holding relay or to the gate of a triac which enables the relay or triac to conduct, thus providing a parallel circuit by-passing the ON/OFF switch. Consequently, when the user releases the trigger and opens the ON/OFF switch, the parallel relay or triac maintains current flow to the motor. It can be seen that in hammer only mode the user can activate the hammer drill by simply tapping the trigger to depress it and does not need to hold down trigger during use of the hammer in operation.

Abstract: The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Abstract: The present invention is directed to compounds of Formula I: I (where variables R1, R2, R3 and R4 are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to the use of such compounds as ligands of AM receptors for the treatment or prevention of diseases in which AM is involved, such as cancer. The invention is further directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP and/or AM are involved.

Abstract: The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Abstract: Lubricating oil additive concentrates containing oil of lubricating viscosity, at least one basic metal complex, an oil-soluble hydrocarbyl phenol aldehyde condensate, and an organic friction modifier containing at least one hydroxyl and/or amino group.

Abstract: Use of a lubricating oil composition comprising, or made by admixing, a major amount of oil of lubricating viscosity, and minor amounts of (A) a dispersant additive composition and (B) a detergent additive composition, wherein the oil composition gives a sulfated ash content of at most 1.0 mass %; has a total base number (TBN) of 4 to 9.5; has at least 0.08 mass % of nitrogen derived from the dispersant additive composition, based on the mass of the oil composition; and has at least 25 mmol of soap per 1000 g of the oil composition derived from the detergent additive composition, to improve the cleanliness of pistons in an engine.

Abstract: A multigrade crankcase lubricating oil composition comprising a mineral oil-based basestock of lubricating viscosity in a major amount and a non-hydrogenated olefin polymer in a minor amount. The lubricating oil composition also comprises a dispersant, a metal detergent, one or more other additives, and a viscosity modifier.

Abstract: Methods and compositions are provided for the production of human manganese superoxide dismutase and a protocol for enhancing efficiency of expression. The gene encoding for human manganese superoxide dismutase was isolated and inserted into a vector in conjunction with a synthetic linker which provides for enhanced efficiency in translation. E. coli strain HB101 containing the plasmid Nco5AHSODm was deposited at the A.T.C.C. on Oct. 3, 1986 and given Accession No. 67191.

Abstract: An SAE OW-30 or 5W-30 or 5W-20 lubricant has a Noack volatility of less than 15, optionally an M-111 fuel economy of 1.5% or less, and a chlorine content of less than 100 ppm. The lubricant comprises a basestock containing from 0 to less than 10% Group I and/or Group II basestocks, a molybdenum additive providing not greater than 1000 ppm of molybdenum to the lubricant, a calcium detergent providing 10 or greater mmoles of surfactant per kilogram of lubricant, one or more other additives, and a viscosity modifier.

Abstract: Methods and compositions are provided for the production of human manganese superoxide dismutase and a protocol for enhancing efficiency of expression. The gene encoding for human manganese superoxide dismutase was isolated and inserted into a vector in conjunction with a synthetic linker which provides for enhanced efficiency in translation.

Abstract: A method of laser-drilling a hole through a workpiece, such as an injector nozzle (40), into a cavity comprising drilling a hole (41) through the workpiece (40) with a laser (50), providing a fluid having laser-barrier properties in the cavity so that, when the hole (41) is open to the cavity, laserlight passing through the hole (41) is incident upon the fluid whereby the workpiece (40) across the cavity from the hole (41) is protected from the laserlight, and arranging that the fluid does not enter the laser-drillled hole (41) during the drilling process. Apparatus for performing the method is also described.