Patents by Inventor Ian BLUMENTHAL

Ian BLUMENTHAL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN
    Publication number: 20240226160
    Abstract: Activity-inducible fusion proteins whose activity is post-translationally regulated utilizing a hsp90 binding domain and a drug molecule are described. In the absence of the drug molecule, the activity-inducible fusion proteins are inactivated but can be activated by a relevant physiological parameter in the presence of the drug molecule. Examples of the activity-inducible fusion proteins include chimeric antigen receptors (CAR) wherein the relevant physiological parameter is antigen binding.
    Type: Application
    Filed: February 11, 2022
    Publication date: July 11, 2024
    Applicant: Seattle Children's Hospital d/b/a Seattle Children's Research Institute
    Inventors: Ryan Koning, Adam Johnson, Chris Saxby, Michael C. Jensen, Ian Blumenthal, Aquene Reid
  • ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN
    Publication number: 20240131072
    Abstract: Activity-inducible fusion proteins whose activity is post-translationally regulated utilizing a hsp90 binding domain and a drug molecule are described. In the absence of the drug molecule, the activity-inducible fusion proteins are inactivated but can be activated by a relevant physiological parameter in the presence of the drug molecule. Examples of the activity-inducible fusion proteins include chimeric antigen receptors (CAR) wherein the relevant physiological parameter is antigen binding.
    Type: Application
    Filed: February 11, 2022
    Publication date: April 25, 2024
    Applicant: Seattle Children's Hospital d/b/a Seattle Children's Research Institute
    Inventors: Ryan Koning, Adam Johnson, Chris Saxby, Michael C. Jensen, Ian Blumenthal, Aquene Reid
  • CELL BASED METHODS AND COMPOSITIONS FOR THERAPEUTIC AGENT DELIVERY AND TREATMENTS USING SAME
    Publication number: 20200405881
    Abstract: Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.
    Type: Application
    Filed: March 6, 2018
    Publication date: December 31, 2020
    Applicants: UNIVERSITY OF WASHINGTON, SEATTLE CHILDREN'S RESEARCH INSTITUTE, COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
    Inventors: Patrick S. STAYTON, Anthony CONVERTINE, Debobrato DAS, Hye-Nam SON, Selvi SRINIVASAN, Katherine MONTGOMERY, Ian BLUMENTHAL, Courtney CRANE, Michael JENSEN, James MATTHAEI, John CHIEFARI, Maarten DANIAL, Fei HUANG, James MACDONALD, Almar POSTMA, Kathleen TURNER