Abstract: A system and method for providing compliance predictions for using a respiratory pressure therapy device in a treatment regimen is disclosed. The system includes a respiratory pressure therapy device having a transmitter and an air control device to provide respiratory therapy to a patient. The respiratory pressure therapy device collects operational data and transmits the collected operational data. Demographic data of the patient is collected. A predicted compliance with the treatment regimen is determined based on inputting operational data and demographic data to a machine learning compliance prediction model having a compliance prediction output. The machine learning model is trained from the operational data and demographic data of a population of patients using respiratory pressure therapy devices.

Abstract: A method of designing a fluid-filled contact lens (103) is described. The method involves generating a computational model that includes a fluid-filled lens (103) and the shape of a cornea causes deformation of an internal structure of the fluid-filled lens (103) to generate a deformed, fluid-filled lens (103) with altered optical properties. The method also includes modelling (5) the optical properties of the deformed, fluid-filled lens (103). The shape of the fluid-filled lens (103) is then adjusted (7) to reduce the effects of the deformation on the optical properties. This is referred to as an adjusted fluid-filled lens (103). A corresponding off-eye lens design is generated (110 based on the adjusted fluid-filled lens design.

Abstract: The present disclosure relates to a membrane (140) suitable for forming at least part of a contact lens (500) by bonding to a bulk lens portion (540). The membrane has a central axis (168). The membrane comprises: a first face (142); a second face (144); and a peripheral edge (160). In a cross-sectional plane passing through and parallel to the central axis of the membrane, the thickness (148) of the membrane is at least 10 microns at a distance of 60 microns from the peripheral edge. The present disclosure also relates to a contact lens (500). The contact lens comprises a membrane (140), a bulk lens portion (540), and a bonding interface (510) between at least part of the membrane and at least part of the bulk lens portion. The present disclosure also relates to a method of manufacturing a contact lens.

Abstract: The present application provides a method and system for the characterization of properties of liquids, particularly petroleum and petroleum liquids. The method and system can be used to take measurements of the liquid directly in a storage container, without exposing the contents of the container to the external environment.

Abstract: The present disclosure concerns a tuneable ophthalmic lens 200. The tuneable ophthalmic lens comprises an activated state and a deactivated state. The ophthalmic lens further comprises a central chamber 206b. The ophthalmic lens also comprises a fluid reservoir, the fluid reservoir being in fluid communication with the central chamber. The fluid reservoir comprises a pump for pumping fluid between the fluid reservoir and the central chamber. In the deactivated state the central chamber is substantially empty of fluid 208a. In the activated state the central chamber is not substantially empty of fluid.

Abstract: Methods and apparatus for making lens assemblies that can be placed on an eye of a person and that include at least one component are described. Generally, a first lens member (100) and a second lens member (200) are formed. The second lens member (200) is transferred to a compliant stage (210). At least one component is placed in contact with one of the lens members (100, 200). The second lens member (200) is placed in contact with the first lens member (100) such that the compliant stage (210) can provide compression to the first and second lens members (100, 200). The second lens member (200) and the first lens member (100) are coupled together to form a lens assembly (10) with the at least one component located between the two lens members (100, 200).

Abstract: Aspects involve an exercise system in which various methods may be practiced. The exercise system facilitates a method of controlling an exercise on a motorized exercise device where the method involves, at a remote computing device, accessing an exercise template including fields associated with an exercise, obtaining a first exercise definition from matching the first exercise template with a first of a plurality of predefined exercises, and providing an exercise definition to a local device for controlling a motorized exercise device, the exercise definition based on matching the exercise template with a first of a plurality of predefined exercises, the exercise definition including a parameter associated with a resistance force that will be used to control a motor of the motorized exercise device when the first exercise is performed at the exercise device.

Abstract: Multilayer contact lenses and methods of making the same are described. A contact lens (100) includes a lens assembly (103). The lens assembly (103) includes a plurality of flexible lens layers. A first layer (101) has a uniform or smooth anterior surface (106), and a second layer (102) has a structured posterior surface that includes one or more recesses (105). The anterior surface (106) of the first layer (101) and the structured posterior surface of the second layer (102) define a first cavity (107) for containing one or more components.

Abstract: A method for identifying imbalances in facility operations. The method includes determining an existence of an imbalance between a first volume of a component at a first point in the facility and a second volume of the component at a second point in the facility, calculating a probability likelihood of the imbalance being caused by one or more likely errors of a set of known likely errors, determining an impact magnitude on the imbalance of each of the one or more likely errors, and assigning an importance ranking to each of the one or more likely errors based on the probability likelihood and the impact magnitude.

Abstract: A tuneable contact lens (100), wherein the contact lens comprises a central region (108). The central region has a circumferential wall and an anterior surface having an external curvature. The contact lens also comprises an inflatable ring (106) arranged around the circumferential wall of the central region, and at least one fluid reservoir (104) in fluid connection with the inflatable ring. The at least one fluid reservoir comprises a pump. When fluid is pumped from the at least one fluid reservoir to the inflatable ring, the inflatable ring inflates and the external curvature of anterior portion of the central region is changed.

Abstract: The present application provides a method and system for the characterization of properties of liquids, particularly petroleum and petroleum liquids. The method and system can be used to take measurements of the liquid directly in a storage container, without exposing the contents of the container to the external environment.

Abstract: According to at least one exemplary embodiment, a system, method, and apparatus for predicting physical properties by indirect measurement is disclosed. The system, method, and apparatus provide for measurement of physical properties of petroleum products by calculating predictions of the properties based on diverse inputs. These predictions may be updated in real time and may be used to modify various processes in midstream and downstream petroleum operations. Various use cases for the system, method, and apparatus for predicting physical properties by indirect measurement are disclosed.

Abstract: The present disclosure concerns a tuneable ophthalmic lens 200. The tuneable ophthalmic lens comprises an activated state and a deactivated state. The ophthalmic lens further comprises a central chamber 206b. The ophthalmic lens also comprises a fluid reservoir, the fluid reservoir being in fluid communication with the central chamber. The fluid reservoir comprises a pump for pumping fluid between the fluid reservoir and the central chamber. In the deactivated state the central chamber is substantially empty of fluid 208a. In the activated state the central chamber is not substantially empty of fluid.

Abstract: The disclosure relates to methods and compositions for the treatment of Systemic Lupus Erythematosus (SLE). Specifically, the disclosure relates to methods comprising administering to a subject a type I IFN receptor inhibitor.

Abstract: A tuneable contact lens (100), wherein the contact lens comprises a central region (108). The central region has a circumferential wall and an anterior surface having an external curvature. The contact lens also comprises an inflatable ring (106) arranged around the circumferential wall of the central region, and at least one fluid reservoir (104) in fluid connection with the inflatable ring. The at least one fluid reservoir comprises a pump. When fluid is pumped from the at least one fluid reservoir to the inflatable ring, the inflatable ring inflates and the external curvature of anterior portion of the central region is changed.

Abstract: Multilayer contact lenses and methods of making the same are described. A contact lens (100) includes a lens assembly (103). The lens assembly (103) includes a plurality of flexible lens layers. A first layer (101) has a uniform or smooth anterior surface (106), and a second layer (102) has a structured posterior surface that includes one or more recesses (105). The anterior surface (106) of the first layer (101) and the structured posterior surface of the second layer (102) define a first cavity (107) for containing one or more components.

Abstract: A method of designing a fluid-filled contact lens (103) is described. The method involves generating a computational model that includes a fluid-filled lens (103) and the shape of a cornea causes deformation of an internal structure of the fluid-filled lens (103) to generate a deformed, fluid-filled lens (103) with altered optical properties. The method also includes modelling (5) the optical properties of the deformed, fluid-filled lens (103). The shape of the fluid-filled lens (103) is then adjusted (7) to reduce the effects of the deformation on the optical properties. This is referred to as an adjusted fluid-filled lens (103). A corresponding off-eye lens design is generated (110 based on the adjusted fluid-filled lens design.

Abstract: Methods and apparatus for making lens assemblies that can be placed on an eye of a person and that include at least one component are described. Generally, a first lens member (100) and a second lens member (200) are formed. The second lens member (200) is transferred to a compliant stage (210). At least one component is placed in contact with one of the lens members (100, 200). The second lens member (200) is placed in contact with the first lens member (100) such that the compliant stage (210) can provide compression to the first and second lens members (100, 200). The second lens member (200) and the first lens member (100) are coupled together to form a lens assembly (10) with the at least one component located between the two lens members (100, 200).

Abstract: A method of manufacturing a contact lens 110 is disclosed. The method comprises manufacturing a rod of lens material 101, the rod 101 containing a plurality of electronic components 102 spaced apart along its length, separating the rod 101 into a plurality of lens blanks 106, each lens blank 106 containing at least one of said electronic components 102, and machining the front and/or back surface of a lens blank 106 to produce a contact lens 110 containing the at least one electronic component 102.

Abstract: The present application provides a method and system for the characterization of properties of liquids, particularly petroleum and petroleum liquids. The method and system can be used to take measurements of the liquid directly in a storage container, without exposing the contents of the container to the external environment.