Patents by Inventor Ian Butterworth
Ian Butterworth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11963750Abstract: A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.Type: GrantFiled: February 7, 2022Date of Patent: April 23, 2024Assignees: Massachusetts Institute of Technology, Universidad Politecnica De MadridInventors: Carlos Castro-Gonzalez, Ian Butterworth, Aurelien Bourquard, Alvaro Sanchez Ferro, Jason Tucker-Schwartz, Alberto Pablo Trinidad, Maria J. Ledesma Carbayo, Tom Vettenburg
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Publication number: 20240085399Abstract: In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images.Type: ApplicationFiled: November 14, 2023Publication date: March 14, 2024Inventors: Carlos Castro Gonzalez, Ian Butterworth, Aurelien Bourquard, Alvaro Sanchez Ferro
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Patent number: 11860154Abstract: In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images.Type: GrantFiled: May 27, 2021Date of Patent: January 2, 2024Assignee: Leuko Labs, IncInventors: Carlos Castro Gonzalez, Ian Butterworth, Aurelien Bourquard, Alvaro Sanchez Ferro
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Publication number: 20230032932Abstract: An automated system for acquiring images of one or more capillaries in a capillary bed includes a platform for receiving a body portion of a subject, an imaging subsystem having a repositionable field of view and coupled to the platform to acquire images of at least a capillary bed of the body portion and a controller communicably coupled to the imaging subsystem to automatically reposition the field of view of the imaging subsystem to different areas of the capillary bed, and at each field of view within the capillary bed, activate the imaging subsystem to acquire images of one or more capillaries in the capillary bed.Type: ApplicationFiled: August 1, 2022Publication date: February 2, 2023Inventors: Ian Butterworth, Carlos Castro-Gonzalez, Aurelien Bourquard, Alvaro Sanchez Ferro, Ganimete Lamaj, Nolan Bell, Ryan Benasutti, Alberto Pablo-Trinidad
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Patent number: 11445980Abstract: Analysis of keystroke dynamics performed by an individual can be used for assessment and monitoring of the individual's motor function. Keystroke events related to a user pressing one or more keys on a keyboard or regions on a touch screen may be analyzed to identify a plurality of distributions of keystroke event intervals. The plurality of distributions may be analyzed to identify one or more features indicative of variation among the distributions and indicative of the user's motor function. Monitoring of a user's motor function may include comparing a value for a feature for one plurality of distribution to a second value for the same feature for another plurality of distributions.Type: GrantFiled: October 28, 2020Date of Patent: September 20, 2022Assignee: Massachusetts Institute of TechnologyInventors: Luca Giancardo, Alvaro Sanchez Ferro, Ian Butterworth, Carlos Sanchez Mendoza
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Publication number: 20220254024Abstract: A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.Type: ApplicationFiled: February 7, 2022Publication date: August 11, 2022Applicants: Massachusetts Institute of Technology, Universidad Politecnica De MadridInventors: Carlos CASTRO-GONZALEZ, Ian BUTTERWORTH, Aurelien BOURQUARD, Alvaro Sanchez FERRO, Jason TUCKER-SCHWARTZ, Alberto PABLO TRINIDAD, MARIA J. LEDESMA CARBAYO, Tom Vettenburg
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Publication number: 20220192589Abstract: A finger insert for use with a nailfold imaging device includes a housing to receive the user's finger and an immersion substance (e.g., immersion oil), and a deformable pad that holds the user's finger in place during imaging, as well as prevent bubble formation in the substance. The housing includes a transparent wall to facilitate imaging of the finger. The transparent wall includes multiple angled portions that prevent or reduce contact between the nailfold and the wall, to ensure sufficient blood flow through the nailfold region for imaging.Type: ApplicationFiled: November 1, 2021Publication date: June 23, 2022Applicant: Massachusetts Institute of TechnologyInventor: Ian BUTTERWORTH
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Patent number: 11244452Abstract: A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.Type: GrantFiled: October 16, 2018Date of Patent: February 8, 2022Assignee: Massachusetts Institute of TechnologyInventors: Carlos Castro-Gonzalez, Ian Butterworth, Aurelien Bourquard, Alvaro Sanchez-Ferro, Jason Tucker-Schwartz, Alberto Pablo-Trinidad, Maria J. Ledesma-Carbayo, Tom Vettenburg
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Publication number: 20210374963Abstract: In one aspect, a method to detect white blood cells and/or white blood cell subtypes from non-invasive capillary videos is featured. The method includes acquiring a first plurality of images of a region of interest including one or more capillaries of a predetermined area of a human subject from non-invasive capillary videos captured with an optical device, processing the first plurality of images to determine one or more optical absorption gaps located in said capillary, and annotating the first plurality of images with an indication of any optical absorption gap detected in the first plurality of images.Type: ApplicationFiled: May 27, 2021Publication date: December 2, 2021Inventors: Carlos Castro Gonzalez, Ian Butterworth, Aurelien Bourquard, Alvaro Sanchez Ferro
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Patent number: 11160492Abstract: A finger insert for use with a nailfold imaging device includes a housing to receive the user's finger and an immersion substance (e.g., immersion oil), and a deformable pad that holds the user's finger in place during imaging, as well as prevent bubble formation in the substance. The housing includes a transparent wall to facilitate imaging of the finger. The transparent wall includes multiple angled portions that prevent or reduce contact between the nailfold and the wall, to ensure sufficient blood flow through the nailfold region for imaging.Type: GrantFiled: May 26, 2020Date of Patent: November 2, 2021Assignee: Massachusetts Institute of TechnologyInventor: Ian Butterworth
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Patent number: 10959676Abstract: Analysis of keystroke dynamics performed by an individual can be used for assessment and monitoring of the individual's motor function. Keystroke events related to a user pressing one or more keys on a keyboard or regions on a touch screen may be analyzed to identify a plurality of distributions of keystroke event intervals. The plurality of distributions may be analyzed to identify one or more features indicative of variation among the distributions and indicative of the user's motor function. Monitoring of a user's motor function may include comparing a value for a feature for one plurality of distribution to a second value for the same feature for another plurality of distributions.Type: GrantFiled: November 4, 2019Date of Patent: March 30, 2021Assignee: Massachusetts Institute of TechnologyInventors: Luca Giancardo, Alvaro Sanchez Ferro, Ian Butterworth, Carlos Sanchez Mendoza
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Publication number: 20210038159Abstract: Analysis of keystroke dynamics performed by an individual can be used for assessment and monitoring of the individual's motor function. Keystroke events related to a user pressing one or more keys on a keyboard or regions on a touch screen may be analyzed to identify a plurality of distributions of keystroke event intervals. The plurality of distributions may be analyzed to identify one or more features indicative of variation among the distributions and indicative of the user's motor function. Monitoring of a user's motor function may include comparing a value for a feature for one plurality of distribution to a second value for the same feature for another plurality of distributions.Type: ApplicationFiled: October 28, 2020Publication date: February 11, 2021Applicant: Massachusetts Institute of TechnologyInventors: Luca Giancardo, Alvaro Sanchez Ferro, Ian Butterworth, Carlos Sanchez Mendoza
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Publication number: 20210022665Abstract: A finger insert for use with a nailfold imaging device includes a housing to receive the user's finger and an immersion substance (e.g., immersion oil), and a deformable pad that holds the user's finger in place during imaging, as well as prevent bubble formation in the substance. The housing includes a transparent wall to facilitate imaging of the finger. The transparent wall includes multiple angled portions that prevent or reduce contact between the nailfold and the wall, to ensure sufficient blood flow through the nailfold region for imaging.Type: ApplicationFiled: May 26, 2020Publication date: January 28, 2021Applicant: Massachusetts Institute of TechnologyInventor: Ian BUTTERWORTH
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Publication number: 20200060622Abstract: Analysis of keystroke dynamics performed by an individual can be used for assessment and monitoring of the individual's motor function. Keystroke events related to a user pressing one or more keys on a keyboard or regions on a touch screen may be analyzed to identify a plurality of distributions of keystroke event intervals. The plurality of distributions may be analyzed to identify one or more features indicative of variation among the distributions and indicative of the user's motor function. Monitoring of a user's motor function may include comparing a value for a feature for one plurality of distribution to a second value for the same feature for another plurality of distributions.Type: ApplicationFiled: November 4, 2019Publication date: February 27, 2020Applicant: Massachusetts Institute of TechnologyInventors: Luca Giancardo, Alvaro Sanchez Ferro, Ian Butterworth, Carlos Sanchez Mendoza
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Patent number: 10506979Abstract: Analysis of keystroke dynamics performed by an individual can be used for assessment and monitoring of the individual's motor function. Keystroke events related to a user pressing one or more keys on a keyboard or regions on a touch screen may be analyzed to identify a plurality of distributions of keystroke event intervals. The plurality of distributions may be analyzed to identify one or more features indicative of variation among the distributions and indicative of the user's motor function. Monitoring of a user's motor function may include comparing a value for a feature for one plurality of distribution to a second value for the same feature for another plurality of distributions.Type: GrantFiled: December 7, 2017Date of Patent: December 17, 2019Assignee: Massachusetts Institute of TechnologyInventors: Luca Giancardo, Alvaro Sanchez Ferro, Ian Butterworth, Carlos Sanchez Mendoza
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Publication number: 20190139221Abstract: A system for non-invasive hematological measurements includes a platform to receive a body portion of a user and an imaging device to acquire a set of images of a capillary bed in the body portion. For each image, a controller detects one or more capillaries in the body portion of the finger to identify a first set of capillaries by estimating one or more attributes of each capillary (e.g., structural attributes, flow attributes, imaging attributes, or combinations thereof), wherein at least one attribute of each capillary meets a predetermined criterion. The controller also identifies a second set of capillaries from the first set of capillaries such that each capillary of the second set of capillaries is visible in a predetermined number of images of the set of images.Type: ApplicationFiled: October 16, 2018Publication date: May 9, 2019Inventors: Carlos Castro-Gonzalez, Ian BUTTERWORTH, Aurelien BOURQUARD, Alvaro SANCHEZ-FERRO, Jason TUCKER-SCHWARTZ, Alberto PABLO-TRINIDAD, MARIA J. LEDESMA-CARBAYO, Tom VETTENBURG
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Publication number: 20180235548Abstract: Analysis of keystroke dynamics performed by an individual can be used for assessment and monitoring of the individual's motor function. Keystroke events related to a user pressing one or more keys on a keyboard or regions on a touch screen may be analyzed to identify a plurality of distributions of keystroke event intervals. The plurality of distributions may be analyzed to identify one or more features indicative of variation among the distributions and indicative of the user's motor function. Monitoring of a user's motor function may include comparing a value for a feature for one plurality of distribution to a second value for the same feature for another plurality of distributions.Type: ApplicationFiled: December 7, 2017Publication date: August 23, 2018Applicant: Massachusetts Institute of TechnologyInventors: Luca Giancardo, Alvaro Sanchez Ferro, Ian Butterworth, Carlos Sanchez Mendoza
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Patent number: 9984277Abstract: Systems, apparatus, and methods for non-invasively detecting a white blood cell (WBC) event from in vivo capillary data may include obtaining a plurality of images, followed by specifying two-dimensional (2D) coordinates corresponding to internal contour and external contour of a capillary visible in the images. The two sets of 2D coordinates may be resampled to generate two sets of resampled coordinates, between which intermediate curves, including a middle curve, are generated. Curvilinear distances may be defined based on the middle curve. Intensity values, each of which corresponds to one of the images, one of the intermediate curves, and one of the curvilinear distances, may be extracted and transformed to the Radon domain. A plurality of maxima locations in the Radon domain corresponding to a flow trajectory inside the capillary may be identified. Detection of a visual gap in the flow trajectory inside the capillary indicates a WBC event.Type: GrantFiled: November 24, 2015Date of Patent: May 29, 2018Assignee: Massachusetts Institute of TechnologyInventors: Carlos Castro-Gonzalez, Ian Butterworth, Aurelien Bourquard, Alvaro Sanchez-Ferro
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Patent number: 9867573Abstract: Analysis of keystroke dynamics performed by an individual can be used for assessment and monitoring of the individual's motor function. Keystroke events related to a user pressing one or more keys on a keyboard or regions on a touch screen may be analyzed to identify a plurality of distributions of keystroke event intervals. The plurality of distributions may be analyzed to identify one or more features indicative of variation among the distributions and indicative of the user's motor function. Monitoring of a user's motor function may include comparing a value for a feature for one plurality of distribution to a second value for the same feature for another plurality of distributions.Type: GrantFiled: March 25, 2015Date of Patent: January 16, 2018Assignee: Massachusetts Institute of TechnologyInventors: Luca Giancardo, Alvaro Sanchez Ferro, Ian Butterworth, Carlos Sanchez Mendoza
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Publication number: 20160148038Abstract: Systems, apparatus, and methods for non-invasively detecting a white blood cell (WBC) event from in vivo capillary data may include obtaining a plurality of images, followed by specifying two-dimensional (2D) coordinates corresponding to internal contour and external contour of a capillary visible in the images. The two sets of 2D coordinates may be resampled to generate two sets of resampled coordinates, between which intermediate curves, including a middle curve, are generated. Curvilinear distances may be defined based on the middle curve. Intensity values, each of which corresponds to one of the images, one of the intermediate curves, and one of the curvilinear distances, may be extracted and transformed to the Radon domain. A plurality of maxima locations in the Radon domain corresponding to a flow trajectory inside the capillary may be identified. Detection of a visual gap in the flow trajectory inside the capillary indicates a WBC event.Type: ApplicationFiled: November 24, 2015Publication date: May 26, 2016Inventors: Carlos CASTRO-GONZALEZ, Ian BUTTERWORTH, Aurelien BOURQUARD, Alvaro SANCHEZ-FERRO