Patents by Inventor Ian Cheong
Ian Cheong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11667946Abstract: The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present invention relates to the rapid and accurate detection of beta-hemolytic pathogens using sterically-stabilized liposomes.Type: GrantFiled: October 22, 2020Date of Patent: June 6, 2023Assignee: Temasek Life Sciences Laboratory LimitedInventors: Rongji Sum, Muthukaruppan Swaminathan, Ian Cheong
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Patent number: 11331272Abstract: Hyperstable liposome comprising an anti-mitotic agent, one or more anions and one or more cations entrapped in the inner milieu, wherein the entrapped anti-mitotic drug is released at a slow rate that is less than 0.6% in 12 hours or less than 5% in 8 hours when the liposomes are suspended in 600 mM sucrose. These liposomes are useful in the treatment of cancer. In particular, HEPC:Chol:DSPE-PEG2000 (50:45:5) liposomes comprising BI 2536 and citrate:phosphate in a ratio of 1:3.Type: GrantFiled: January 17, 2018Date of Patent: May 17, 2022Assignee: Temasek Life Sciences Laboratory LimitedInventors: Chang Zhi Adrian Ng, Shen-Yi Ian Cheong
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Publication number: 20210108246Abstract: The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present invention relates to the rapid and accurate detection of beta-hemolytic pathogens using sterically-stabilized liposomes.Type: ApplicationFiled: October 22, 2020Publication date: April 15, 2021Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Rongji SUM, Muthukaruppan SWAMINATHAN, Ian CHEONG
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Patent number: 10844418Abstract: The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present invention relates to the rapid and accurate detection of beta-hemolytic pathogens using sterically-stabilized liposomes.Type: GrantFiled: February 23, 2017Date of Patent: November 24, 2020Assignee: TEMASEK LIFE SCIENCES LABORATORYInventors: Rongji Sum, Muthukaruppan Swaminathan, Ian Cheong
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Publication number: 20190358161Abstract: Hyperstable liposome comprising an anti-mitotic agent, one or more anions and one or more cations entrapped in the inner milieu, wherein the entrapped anti-mitotic drug is released at a slow rate that is less than 0.6% in 12 hours or less than 5% in 8 hours when the liposomes are suspended in 600 mM sucrose. These liposomes are useful in the treatment of cancer. In particular, HEPC:Chol:DSPE-PEG2000 (50:45:5) liposomes comprising BI 2536 and citrate:phosphate in a ratio of 1:3.Type: ApplicationFiled: January 17, 2018Publication date: November 28, 2019Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Chang Zhi Adrian NG, Shen-Yi Ian CHEONG
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Patent number: 10325183Abstract: An improved system and method for digital image classification is provided. A host computer having a processor is coupled to a memory storing thereon reference feature data. A graphics processing unit (GPU) having a processor is coupled to the host computer and is configured to obtain, from the host computer, feature data corresponding to the digital image; to access, from the memory, the one or more reference feature data; and to determine a semi-metric distance based on a Poisson-Binomial distribution between the feature data and the one or more reference feature data. The host computer is configured to classify the digital image using the determined semi-metric distance.Type: GrantFiled: September 15, 2015Date of Patent: June 18, 2019Assignee: Temasek Life Sciences Laboratory LimitedInventors: Muthukaruppan Swaminathan, Tobias Sjoblom, Ian Cheong, Obdulio Piloto
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Publication number: 20190062799Abstract: The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present invention relates to the rapid and accurate detection of beta-hemolytic pathogens using sterically-stabilized liposomes.Type: ApplicationFiled: February 23, 2017Publication date: February 28, 2019Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Rongji SUM, Muthukaruppan SWAMINATHAN, Ian CHEONG
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Publication number: 20170249535Abstract: An improved system and method for digital image classification is provided. A host computer having a processor is coupled to a memory storing thereon reference feature data. A graphics processing unit (GPU) having a processor is coupled to the host computer and is configured to obtain, from the host computer, feature data corresponding to the digital image; to access, from the memory, the one or more reference feature data; and to determine a semi-metric distance based on a Poisson-Binomial distribution between the feature data and the one or more reference feature data. The host computer is configured to classify the digital image using the determined semimetric distance.Type: ApplicationFiled: September 15, 2015Publication date: August 31, 2017Inventors: Muthukaruppan SWAMINATHAN, Tobias SJOBLOM, Ian CHEONG, Obdulio PILOTO
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Publication number: 20150306184Abstract: Clostridium novyi is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated with C. novyi plus a single dose of liposomal doxorubicin. The secreted factor responsible for this phenomenon was identified and, surprisingly, proved to be a member of the lipase family. The gene encoding this protein, called liposomase, has the potential to be incorporated into diverse therapeutic methods to deliver specifically a variety of chemotherapeutic agents to tumors.Type: ApplicationFiled: December 1, 2014Publication date: October 29, 2015Inventors: Ian Cheong, Shibin Zhou, Kenneth W. Kinzler, Bert Vogelstein
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Patent number: 8901100Abstract: Clostridium novyi is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated with C. novyi plus a single dose of liposomal doxorubicin. The secreted factor responsible for this phenomenon was identified and, surprisingly, proved to be a member of the lipase family. The gene encoding this protein, called liposomase, has the potential to be incorporated into diverse therapeutic methods to deliver specifically a variety of chemotherapeutic agents to tumors.Type: GrantFiled: August 9, 2013Date of Patent: December 2, 2014Assignee: The Johns Hopkins UniversityInventors: Ian Cheong, Shibin Zhou, Kenneth W. Kinzler, Bert Vogelstein
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Publication number: 20130315986Abstract: Clostridium novyi is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated with C. novyi plus a single dose of liposomal doxorubicin. The secreted factor responsible for this phenomenon was identified and, surprisingly, proved to be a member of the lipase family. The gene encoding this protein, called liposomase, has the potential to be incorporated into diverse therapeutic methods to deliver specifically a variety of chemotherapeutic agents to tumors.Type: ApplicationFiled: August 9, 2013Publication date: November 28, 2013Applicant: Johns Hopkins UniversityInventors: Ian CHEONG, Shibin ZHOU, Kenneth W. KINZLER, Bert VOGELSTEIN
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Patent number: 8568708Abstract: Clostridium novyi is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated with C. novyi plus a single dose of liposomal doxorubicin. The secreted factor responsible for this phenomenon was identified and, surprisingly, proved to be a member of the lipase family. The gene encoding this protein, called liposomase, has the potential to be incorporated into diverse therapeutic methods to deliver specifically a variety of chemotherapeutic agents to tumors.Type: GrantFiled: December 3, 2012Date of Patent: October 29, 2013Assignee: The John Hopkins UniversityInventors: Ian Cheong, Shibin Zhou, Kenneth W. Kinzler, Bert Vogelstein
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Patent number: 8444963Abstract: Clostridium novyi is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated with C. novyi plus a single dose of liposomal doxorubicin. The secreted factor responsible for this phenomenon was identified and, surprisingly, proved to be a member of the lipase family. The gene encoding this protein, called liposomase, has the potential to be incorporated into diverse therapeutic methods to deliver specifically a variety of chemotherapeutic agents to tumors.Type: GrantFiled: June 19, 2007Date of Patent: May 21, 2013Assignee: John Hopkins UniversityInventors: Ian Cheong, Shibin Zhou, Kenneth W. Kinzler, Bert Vogelstein
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Publication number: 20110250258Abstract: Clostridium novyi is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated with C. novyi plus a single dose of liposomal doxorubicin. The secreted factor responsible for this phenomenon was identified and, surprisingly, proved to be a member of the lipase family. The gene encoding this protein, called liposomase, has the potential to be incorporated into diverse therapeutic methods to deliver specifically a variety of chemotherapeutic agents to tumors.Type: ApplicationFiled: June 19, 2007Publication date: October 13, 2011Applicant: JOHNS HOPKINS UNIVERSITYInventors: Ian Cheong, Shibin Zhou, Kenneth W. Kinzler, Bert Vogelstein