Abstract: The invention relates to solid forms of cenicriviroc mesylate, methods of their preparation, pharmaceutical compositions thereof and methods of their use.

Abstract: This invention relates to antibacterial drug compounds containing a bicyclic core, typically a bicycle in which one of the rings is an oxazolidinone. It also relates to pharmaceutical formulations of antibacterial drug compounds. It also relates to uses of the compounds in treating bacterial infections and in methods of treating bacterial infections.

Abstract: This invention relates to antibacterial drug compounds containing a bicyclic core, typically a bicycle in which one of the rings is an oxazolidinone. It also relates to pharmaceutical formulations of antibacterial drug compounds. It also relates to uses of the derivatives in treating bacterial infections and in methods of treating bacterial infections.

Abstract: Novel solid forms of bendamustine hydrochloride are described, as well as methods of their preparation and use.

Abstract: Novel solid forms of bendamustine hydrochloride are described, as well as methods of their preparation and use.

Abstract: Disclosed is a compound of formula (I): crystalline forms thereof, and solvates thereof; pharmaceutical compositions comprising a pharmaceutically effective amount of the compound of formula (I), or a crystalline form thereof, or a solvate thereof, and a pharmaceutically acceptable carrier or diluent; and the use of a compound of formula (I), or a crystalline form thereof, or a solvate thereof, for treating a patient suffering from, or subject to, a pathological condition capable of being ameliorated by inhibiting an E1 activating enzyme, particularly NAE, including, e.g., cancer.

Abstract: A the network-side distribution point in a telecommunications network includes an input measurement function which monitors the total power delivered to the power combiner from the various customer premises, and an output measurement function which monitors the total power requirements of the components of the distribution point. The data from these monitoring functions are used by a power extraction control unit to control the combiner/extraction unit to draw power from the forward power feed to makes up any shortfall in the power required to operate the components. This allows each customer premises system to deliver power to the distribution point at a rate determined only by the services it is itself using, and without any need for co-ordination between the distribution point and the customer premises systems.

Abstract: The invention relates to solid forms of cenicriviroc mesylate, methods of their preparation, pharmaceutical compositions thereof and methods of their use.

Abstract: A flexible hose comprising: a flexible conduit for carrying a pressurized fluid; a flexible inner support for supporting the conduit; and a compression layer surrounding the flexible conduit.

Abstract: A high speed vertical textile lapper has a comb reciprocated by a first motor and a presser bar reciprocated by a second motor, both motors being under a common servo motor control. The linear comb is reciprocated by a comb crankshaft in a crankcase while the presser bar is reciprocated by a bar crankshaft in order to deposit a lapped web onto a horizontal conveyor which sends the web through an oven where some of the web fibers fuse to adhere the finished web. The incoming web to be plated is carried to the lapping zone by a combination of horizontal and vertical conveyors. These feed the descending web close to the lapping zone. The comb crankcase has pressurized lubrication and external cooling. The servo control permits PLC synchronization.

Abstract: A the network-side distribution point in a telecommunications network includes an input measurement function which monitors the total power delivered to the power combiner from the various customer premises, and an output measurement function which monitors the total power requirements of the components of the distribution point. The data from these monitoring functions are used by a power extraction control unit to control the combiner/extraction unit to draw power from the forward power feed to makes up any shortfall in the power required to operate the components. This allows each customer premises system to deliver power to the distribution point at a rate determined only by the services it is itself using, and without any need for co-ordination between the distribution point and the customer premises systems.

Abstract: Novel solid forms of bendamustine hydrochloride are described, as well as methods of their preparation and use.

Abstract: Disclosed is a compound of formula (I): crystalline forms thereof, and solvates thereof; pharmaceutical compositions comprising a pharmaceutically effective amount of the compound of formula (I), or a crystalline form thereof, or a solvate thereof, and a pharmaceutically acceptable carrier or diluent; and the use of a compound of formula (I), or a crystalline form thereof, or a solvate thereof, for treating a patient suffering from, or subject to, a pathological condition capable of being ameliorated by inhibiting an E1 activating enzyme, particularly NAE, including, e.g., cancer.

Abstract: Novel solid forms of bendamustine hydrochloride are described, as well as methods of their preparation and use.

Abstract: A high speed vertical textile lapper has a comb reciprocated by a first motor and a presser bar reciprocated by a second motor, both motors being under a common servo motor control. The linear comb is reciprocated by a comb crankshaft in a crankcase while the presser bar is reciprocated by a bar crankshaft in order to deposit a lapped web onto a horizontal conveyor which sends the web through an oven where some of the web fibres fuse to adhere the finished web. The incoming web to be plated is carried to the lapping zone by a combination of horizontal and vertical conveyors. These feed the descending web close to the lapping zone. The comb crankcase has pressurised lubrication and external cooling. The servo control permits PLC synchronisation.

Abstract: Novel solid forms of bendamustine hydrochloride are described, as well as methods of their preparation and use.

Abstract: Disclosed is a compound of formula (I): crystalline forms thereof, and solvates thereof; pharmaceutical compositions comprising a pharmaceutically effective amount of the compound of formula (I), or a crystalline form thereof, or a solvate thereof, and a pharmaceutically acceptable carrier or diluent; and the use of a compound of formula (I), or a crystalline form thereof, or a solvate thereof, for treating a patient suffering from, or subject to, a pathological condition capable of being ameliorated by inhibiting an E1 activating enzyme, particularly NAE, including, e.g., cancer.

Abstract: Disclosed is a compound of formula (I): crystalline forms thereof, and solvates thereof; pharmaceutical compositions comprising a pharmaceutically effective amount of the compound of formula (I), or a crystalline form thereof, or a solvate thereof, and a pharmaceutically acceptable carrier or diluent; and the use of a compound of formula (I), or a crystalline form thereof, or a solvate thereof, for treating a patient suffering from, or subject to, a pathological condition capable of being ameliorated by inhibiting an E1 activating enzyme, particularly NAE, including, e.g., cancer.

Abstract: This invention provides a compound of formula (I): or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; processes for the synthesis or manufacture of the compound of formula (I), or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof; and the use of said compound, or a crystalline form thereof, or a pharmaceutical composition thereof, or an oral pharmaceutical dosage form thereof, for the treatment of patients suffering from or subject to diseases, disorders or conditions involving cell survival, proliferation, and migration, including cardiovascular disease (e.g., arteriosclerosis and vascular reobstruction), cancer, (e.g., AML and malignant glioma) glomerulosclerosis, fibrotic disease and inflammation.

Abstract: Novel solid forms of bendamustine hydrochloride are described, as well as methods of their preparation and use.