Abstract: The present disclosure relates to bacterium engineered to produce aromatic compounds or compounds with aromatic metabolites or intermediates using the CRISPR-CAS transcriptional activation (CRISPRa) and/or transcriptional repression (CRISPRi). Accordingly, in an aspect the present disclosure relates to an engineered bacterium comprising genetic elements supporting programmable transcriptional activation and/or repression. The present disclosure also provides methods and systems for producing aromatic compounds or compounds with aromatic metabolites or intermediates using the engineered bacterium disclosed herein.

Abstract: Radioactive seeds, particularly I-125 radioiodine seeds, are sterilised by being subjected to dry heat at a temperature of at least 140° C., preferably 150-200° C. A container having loose sterile radioactive seeds therein is disclosed. The container is preferably of glass with a label and a removable heat-resistant silicone closure.

Abstract: Radioactive seeds, particularly 1-125 radioiodine seeds are sterilized by being subjected to dry heat at a temperature of at least 140° C., preferably 150-200° C. A container having loose sterile radioactive seeds therein is disclosed. The container is preferably of glass with a label and a removable heat-resistant silicone closure.