Abstract: Methods for classifying a core cane of an multimode optical fiber are disclosed. In embodiments, the method includes determining a relative refractive index profile ?(r) of the core cane; fitting the relative refractive index profile ?(r) to an alpha profile ?fit(r) defined by: ? fit ( r ) = ? o , fit ( 1 - ( r a fit ) ? fit ) where ?o,fit is a relative refractive index at a longitudinal centerline of the core cane, ?fit is a core shape parameter, and afit is an outer radius of the core cane; generating a non-alpha residual profile ?diff(r)=?(r)??fit(r) for the core cane; computing one or more metrics from ?diff(r), and using the one or metrics in a classification of the core cane, the classification comprising a prediction of whether a bandwidth at a pre-determined wavelength of an optical fiber drawn from a preform comprising the core cane exceeds a pre-determined bandwidth at the pre-determined wavelength.

Abstract: According to some embodiments a method of measuring the refractive index profile of a consolidated glass body having a cylindrical surface comprises the steps of: (a) forming an image of a slit behind the glass body; (b) optionally pre-scanning the cylindrical surface of the test glass body or a reference glass body and analyzing the data within a fixed window to determine the likely location of the zero-order, un-diffracted beam while ignoring other diffracted beams; (c) optionally adjusting the optical power to improve the intensity of the data within the fixed window in order to improve the analysis; (d) predicting the trajectory of the zero-order beam through the preform based on the sampling location xi (incidence position) of the light impinging on the cylindrical surface and the location at which the zero-order beam impinges on the detector; (e) measuring the cylindrical surface of a glass body while using the estimated location of the zero-order beam and adjusted optical power to set the center of a f

Abstract: According to some embodiments a method of measuring the refractive index profile of a consolidated glass body having a cylindrical surface comprises the steps of: (a) forming an image of a slit behind the glass body, (b) optionally pre-scanning the cylindrical surface of the test glass body or a reference glass body and analyzing the data within a fixed window to determine the likely location of the zero-order, un-diffracted beam while ignoring other diffracted beams; (c) optionally adjusting the optical power to improve the intensity of the data within the fixed window in order to improve the analysis; (d) predicting the trajectory of the zero-order beam through the preform based on the sampling location xi (incidence position) of the light impinging on the cylindrical surface and the location at which the zero-order beam impinges on the detector; (e) measuring the cylindrical surface of a glass body while using the estimated location of the zero-order beam and adjusted optical power to set the center of a f

Abstract: The present invention arises from the identification of an association between the TDOA gene and osteoarthritis (OA). It therefore relates to diagnostic techniques for determining a patient's susceptibility to develop OA by detecting all or part of the TDOA gene, its precursors or products (mRNA, cDNA, genomic DNA, or protein). In particular, the invention relates to methods and materials for analysing allelic variation in the TDOA gene, and to the use of TDOA polymorphisms in the identification of an individuals' risk to develop OA. The TDOA protein has been found to bind to ?-paxillin, a protein involved in integrin signal transduction which itself is a process with strong links to OA. The invention is thus also directed to methods for identifying modulators of OA, which modulate the TDOA gene or interfere with TDOA:?-paxillin binding.

Abstract: Methods of screening compounds for their ability to inhibit monocarboxylate transport, and methods of making and using such inhibitors to treat disorders associated with cellular proliferation, e.g., immune-mediated disorders and cancer.