Abstract: Compounds, composition, and kits are provided for use in methods for the assisted folding of protein fragments of a of choice point larger protein by means of induced proximity, forced by specific nucleic acid hybridizations between a target nucleic acid molecule and complementary nucleic acid molecules appended to the protein fragments of interest.

Abstract: The present disclosure provides nucleic acid molecules, compositions, and kits comprising the same, and methods for producing templated assembly products.

Abstract: The present disclosure provides nucleic acid molecules, and kits comprising the same, for producing templated assembly products for a cell.

Abstract: The present disclosure provides nucleic acid molecules, compositions, and kits comprising the same, and methods for producing templated assembly products.

Abstract: The present disclosure provides nucleic acid molecules, and kits comprising the same, for producing templated assembly products for a cell.

Abstract: The present disclosure is directed to methods and kits for identifying, enriching, and evaluating templated assembly reactants. Some embodiments disclose methods for identifying templated assembly targets by synthesizing templated assembly reactants, hybridizing the templated assembly reactants to target nucleic acids, performing a templated assembly reaction, and identifying the target nucleic acids that hybridized to the templated assembly reactants. Libraries of templated assembly reactants, a kit for identifying templated assembly targets, and a pair of templated assembly targets enriched from a library of chemically-ligated oligonucleotides spatially elicited (CLOSE) products are also disclosed.

Abstract: The present disclosure is directed methods and products for synthesizing and using targeted templated assembly reactants comprising at least one nucleic acid recognition moiety, at least one selectively-reactive moiety, and at least one effector partial moiety. The nucleic acid recognition moiety can bind a target nucleic acid sequence within a sample. The nucleic acid recognition moiety also can bind the selectively-reactive moiety. Additionally, the effector partial moiety can bind the selectively-reactive moiety to produce an active effector structure. Also disclosed are methods of delivering the targeted templated assembly reactants and active effector structures formed front the targeted templated assembly reactants.

Abstract: The present disclosure provides polypeptides and polypeptide-nucleic acid conjugates comprising portions of epitopes, and methods of using target molecule binding components, such as aptamers, to present template sequences, where the target molecule binding components bind to target molecules unique to specific cellular targets, for the purpose of templated assembly of the epitopes for recognition molecules.

Abstract: The present disclosure is directed to methods and kits for identifying, enriching, and evaluating templated assembly reactants. Some embodiments disclose methods for identifying templated assembly targets by synthesizing templated assembly reactants, hybridizing the templated assembly reactants to target nucleic acids, performing a templated assembly reaction, and identifying the target nucleic acids that hybridized to the templated assembly reactants. Libraries of templated assembly reactants, a kit for identifying templated assembly targets, and a pair of templated assembly targets enriched from a library of chemically-ligated oligonucleotides spatially elicited (CLOSE) products are also disclosed.

Abstract: The present disclosure is directed methods and products for synthesizing and using targeted templated assembly reactants comprising at least one nucleic acid recognition moiety, at least one selectively-reactive moiety, and at least one effector partial moiety. The nucleic acid recognition moiety can bind a target nucleic acid sequence within a sample. The nucleic acid recognition moiety also can bind the selectively-reactive moiety. Additionally, the effector partial moiety can bind the selectively-reactive moiety to produce an active effector structure. Also disclosed are methods of delivering the targeted templated assembly reactants and active effector structures formed from the targeted templated assembly reactants.

Abstract: The present disclosure provides nucleic acid molecules, compositions, and kits comprising the same, and methods for producing templated assembly products.

Abstract: The present disclosure provides nucleic acid molecules, and kits comprising the same, for producing templated assembly products for a cell.

Abstract: The present disclosure is directed to methods and kits for identifying, enriching, and evaluating templated assembly reactants. Some embodiments disclose methods for identifying templated assembly targets by synthesizing templated assembly reactants, hybridizing the templated assembly reactants to target nucleic acids, performing a templated assembly reaction, and identifying the target nucleic acids that hybridized to the templated assembly reactants. Libraries of templated assembly reactants, a kit for identifying templated assembly targets, and a pair of templated assembly targets enriched from a library of chemically-ligated oligonucleotides spatially elicited (CLOSE) products are also disclosed.

Abstract: The present disclosure provides nucleic acid aptamers, nucleic acid aptamers hybridized to haplomers, methods of using nucleic acid aptamers to present template sequences, where the aptamers bind to target molecules unique to specific cellular targets, for the purpose of nucleic acid-templated assembly of molecules with desired functions.

Abstract: A method of sending and receiving configurable buckets of communication is disclosed. A request to send a communication from an application executing on a client to an application executing on a server is received. The communication has a first priority. A request to send an additional communication from the application executing on the client to the application executing on the server is received. The additional communication has a second priority. The communication is placed into a bucket of communications based on the communication having the first priority. A determination is made to send the bucket of communications to the application executing on the server. The additional communication is placed into the bucket of communications based on a determination that the bucket of communications is not full. The bucket of communications is sent to the application executing on the server.

Abstract: A training device assists soccer players to deflect a soccer ball by bouncing off a vertical wall. The vertical wall includes an anchor wall acting as a brace that extends at an angle where stakes pass through which allows the device to be anchored to ground. The device is made without moving parts as a stand-alone unit that is made by injection molding as a one-piece homogeneous construction. The device can be sold by itself or as a kit having multiple devices including a set of stakes.

Abstract: The present disclosure is directed methods and products for synthesizing and using targeted templated assembly reactants comprising at least one nucleic acid recognition moiety, at least one selectively-reactive moiety, and at least one effector partial moiety. The nucleic acid recognition moiety can bind a target nucleic acid sequence within a sample. The nucleic acid recognition moiety also can bind the selectively-reactive moiety. Additionally, the effector partial moiety can bind the selectively-reactive moiety to produce an active effector structure. Also disclosed are methods of delivering the targeted templated assembly reactants and active effector structures formed from the targeted templated assembly reactants.

Abstract: A method of executing a cross-platform application on a system is disclosed. An instruction pertaining to an execution of the cross-platform application on the system is received. Based on a determination that the instruction pertains to a rendering of an element of a user interface of the cross-platform application on the system, the instruction is sent across a bridge to an engine executing in the native layer to process the instruction at the native layer. Alternatively, based on a determination that the instruction does not pertain to a rendering of the element of the user interface of the cross-platform application on the system, the instruction is sent to an engine executing in the cross-platform layer of the system to process the instruction at the cross-platform layer.

Abstract: A method of sending and receiving configurable buckets of communication is disclosed. A request to send a communication from an application executing on a client to an application executing on a server is received. The communication has a first priority. A request to send an additional communication from the application executing on the client to the application executing on the server is received. The additional communication has a second priority. The communication is placed into a bucket of communications based on the communication having the first priority. A determination is made to send the bucket of communications to the application executing on the server. The additional communication is placed into the bucket of communications based on a determination that the bucket of communications is not full. The bucket of communications is sent to the application executing on the server.

Abstract: A method of sending and receiving configurable buckets of communication is disclosed. A request to send a communication from an application executing on a client to an application executing on a server is received. The communication has a first priority. A request to send an additional communication from the application executing on the client to the application executing on the server is received. The additional communication has a second priority. The communication is placed into a bucket of communications based on the communication having the first priority. A determination is made to send the bucket of communications to the application executing on the server. The additional communication is placed into the bucket of communications based on a determination that the bucket of communications is not full. The bucket of communications is sent to the application executing on the server.