Abstract: A device for concentrating and preserving samples for subsequent analysis, wherein the samples include but are not limited to, biological samples, environmental samples, industrial samples, and the like. The present disclosure further includes a method for utilizing the device for containment, concentration, and preservation of the sample until analysis can take place. The disclosed device is simple to operate and can function without auxiliary equipment and/or sources of power making it particularly suitable for use in locations distanced and isolated from analytical facilities.

Abstract: The present disclosure provides cell-penetrating nucleic acid nanostructures well suited as transfection reagents for the delivery of bioactive agents to cells both in vivo and in vitro for research, diagnostic, and/or therapeutic purposes.

Abstract: A vehicle platoon system may include a database configured to maintain a user profile and data descriptive of existing platoons, and a processor configured to receive a platoon request indicating desire to join a platoon, receive, in response to the request, the user profile defining at least one compliance threshold indicative of a minimum compliance score of other platoon participants, determine whether all members of at least one of the existing platoons have a compliance score exceeding the compliance threshold, and instruct an indication of the platoon to be presented for selection.

Abstract: A vehicle platoon system may include a database configured to maintain a user profile and data descriptive of existing platoons, and a processor configured to receive a platoon request indicating desire to join a platoon, receive, in response to the request, the user profile defining at least one compliance threshold indicative of a minimum compliance score of other platoon participants, determine whether all members of at least one of the existing platoons have a compliance score exceeding the compliance threshold, and instruct an indication of the platoon to be presented for selection.

Abstract: The present disclosure provides cell-penetrating nucleic acid nanostructures well suited as transfection reagents for the delivery of bioactive agents to cells both in vivo and in vitro for research, diagnostic, and/or therapeutic purposes.

Abstract: A minimally invasive surgical instrument including a viewing instrument and a wiper mechanism configured and adapted to clean a lens of the viewing instrument. The wiper mechanism includes a wiper that is configured and adapted to contact and translate across a surface of the lens. An actuator moves the wiper across the lens to clean the lens.

Abstract: A minimally invasive surgical instrument including a viewing instrument and a wiper mechanism configured and adapted to clean a lens of the viewing instrument. The wiper mechanism includes a wiper that is configured and adapted to contact and translate across a surface of the lens. An actuator moves the wiper across the lens to clean the lens.

Abstract: A minimally invasive surgical instrument including a viewing instrument and a wiper mechanism configured and adapted to clean a lens of the viewing instrument. The wiper mechanism includes a wiper that is configured and adapted to contact and translate across a surface of the lens. An actuator moves the wiper across the lens to clean the lens.

Abstract: A surgical retrieval apparatus includes a specimen retrieval bag including a rim movable from a collapsed configuration when positioned within a delivery tube to an automatically expanded configuration when advanced from the delivery tube. The rim is configured to receive a tissue specimen when the rim is in the expanded configuration. The retrieval bag defines a proximal portion with respect to the incision and a distal portion with respect to the incision. A specimen retrieval system further includes a delivery tube defining a longitudinal axis and includes the surgical retrieval apparatus contained therein that is configured to be inserted through a first opening in a patient's skin. The delivery tube defines an internal volume extending from a proximal end to a distal end of the delivery tube. The surgical retrieval apparatus is separable from the delivery tube.

Abstract: A method of retrieving a tissue specimen comprising inserting a surgical retrieval apparatus through an opening in a patient's skin, the surgical retrieval apparatus including a support member and a retrieval bag extending from the support member and having an opening to receive the tissue specimen. A net is introduced into the retrieval bag and placed over the tissue specimen. The net and retrieval bag are removed from the patient's body to remove the tissue specimen.

Abstract: A surgical retrieval apparatus includes an elongate tubular member having a drive rod slidably disposed therein. A support member is operably coupled to a distal end of the drive rod. A pouch is attached to the support member and has a closed end and an open end. The pouch is securely coupled to the support member.

Abstract: The present invention relates to combination comprising (i) an ErbB inhibitor; and (ii) a CDK inhibitor, or a pharmaceutically acceptable salt thereof, selected from: (a) roscovitine; (b) 3-{9-isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-ol; (c) 3-{9-isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-pentan-2-ol; and (d) (2R,3S-3-(6-((4,6-dimethylpyridin-3-ylmethylamino)-9-isopropyl-9H-purin-2-ylamino)pentan-2-ol. Further aspects of the invention relate to pharmaceutical products and pharmaceutical compositions comprising combinations according to the invention, and methods of treatment using the same.

Abstract: A surgical retrieval apparatus includes an elongate tubular member having a drive rod slidably disposed therein. A support member is operably coupled to a distal end of the drive rod. A pouch is attached to the support member and has a closed end and an open end. The pouch is securely coupled to the support member.

Abstract: A specimen retrieval apparatus includes a housing having an elongated tubular member extending distally therefrom. The elongated tubular member defines a longitudinal axis. An end effector assembly is coupled to a distal end of the elongated tubular member. The end effector assembly is configured to retain a specimen retrieval bag thereon. An articulation mechanism is operatively coupled to the elongated tubular member and the end effector assembly. The articulation mechanism is configured for selectively articulating the end effector assembly with respect to the longitudinal axis of the elongated tubular member.

Abstract: A surgical retrieval apparatus includes a housing defining a longitudinal axis and including an elongated sleeve extending distally therefrom. The housing and the elongated sleeve cooperate to define a lumen extending longitudinally therethrough. A shaft having an end effector disposed at a distal end thereof is selectively translatable between a first position, wherein the end effector is disposed within the elongated sleeve, and a second position, wherein the shaft is translated through the lumen such that the end effector extends distally from the elongated sleeve. An articulation mechanism operably coupled to the end effector is configured for articulating the end effector relative to the longitudinal axis. A specimen retrieval bag is coupled to the end effector and is deployed therefrom upon movement of the end effector from the first position to the second position.

Abstract: An instrument for cleaning a scope lens having an elongated sheath having proximal and distal end portions and a sheath interior and exterior. The sheath interior is dimensioned and configured to slidingly receive a scope therein. A fluid conduit transports fluid and has a fluid discharge opening to deliver fluid to the lens of the scope, the conduit coupled to the sheath exterior.

Abstract: A method of retrieving a tissue specimen comprising inserting a surgical retrieval apparatus through an opening in a patient's skin, the surgical retrieval apparatus including a support member and a retrieval bag extending from the support member and having an opening to receive the tissue specimen. A net is introduced into the retrieval bag and placed over the tissue specimen. The net and retrieval bag are removed from the patient's body to remove the tissue specimen.

Abstract: A method of retrieving a tissue specimen comprising inserting a surgical retrieval apparatus through an opening in a patient's skin, the surgical retrieval apparatus including a support member and a retrieval bag extending from the support member and having an opening to receive the tissue specimen. A net is introduced into the retrieval bag and placed over the tissue specimen. The net and retrieval bag are removed from the patient's body to remove the tissue specimen.

Abstract: A method and system for removing tissue from a body cavity is provided. The system includes a retrieval bag that is insertable through a first incision in tissue and includes open and closed ends. A surgical instrument is insertable into the body cavity and configured to grasp and excise a sample/specimen from within the body cavity and selectively substantially seal the retrieval bag. A fluid circulator in fluid communication with the surgical instrument and the open end of the retrieval bag is configured to evacuate gaseous matter from within the body cavity and into the open end of the retrieval bag such that the retrieval bag substantially encircles the excised tissue specimen.

Abstract: A surgical retrieval apparatus includes a housing defining a longitudinal axis and including an elongated sleeve extending distally therefrom. The housing and the elongated sleeve cooperate to define a lumen extending longitudinally therethrough. A shaft having an end effector disposed at a distal end thereof is selectively translatable between a first position, wherein the end effector is disposed within the elongated sleeve, and a second position, wherein the shaft is translated through the lumen such that the end effector extends distally from the elongated sleeve. An articulation mechanism operably coupled to the end effector is configured for articulating the end effector relative to the longitudinal axis. A specimen retrieval bag is coupled to the end effector and is deployed therefrom upon movement of the end effector from the first position to the second position.