Abstract: The present disclosure provides methods for re-stimulating TIL populations that lead to improved phenotype and increased metabolic health of the TILs and provides methods of assaying for TIL populations to determine suitability for more efficacious infusion after re-stimulation.

Abstract: The present disclosure provides methods for re-stimulating TIL populations that lead to improved phenotype and increased metabolic health of the TILs and provides methods of assaying for TIL populations to determine suitability for more efficacious infusion after re-stimulation.

Abstract: A bottle holder for various size bottles that is designed to keep the bottle and liquid cool, enable the user to pour from the bottle while the bottle is in the holder, and protect the bottle from breaking in case of accident. The bottle holder includes a body, comprised of an outer shell and an inner shell, as well as a lid that may be attached to the body such as by screwing it on or by friction. The outer shell preferably has one or more features that enable the user to maintain a better grip. The inner shell and lid have different features to hold the bottle securely. Advantageously, the body and lid provides thermal protection.

Abstract: The present disclosure provides methods for re-stimulating TIL populations that lead to improved phenotype and increased metabolic health of the TILs and provides methods of assaying for TIL populations to determine suitability for more efficacious infusion after re-stimulation.

Abstract: A bottle holder for various size bottles that is designed to keep the bottle and liquid cool, enable the user to pour from the bottle while the bottle is in the holder, and protect the bottle from breaking in case of accident. The bottle holder includes a body, comprised of an outer shell and an inner shell, as well as a lid that may be attached to the body such as by screwing it on or by friction. The outer shell preferably has one or more features that enable the user to maintain a better grip. The inner shell and lid have different features to hold the bottle securely. Advantageously, the body and lid provides thermal protection.

Abstract: A method of disinfection of livestock is provided. The method comprises administering at least one bacteriophage in an effective amount to said livestock to reduce the number of Campylobacter spp present in the gastro-intestinal tract of said livestock. The bacteriophage are selected from CP8 (NCIMB Accession No. 41184) and CP34 (NCIMB Accession No. 41185).

Abstract: A lubricant delivery element for delivering lubricant into a cavity, the lubricant distribution element comprising a thin element of porous material for delivering lubricant into the cavity through the element.

Abstract: The present invention relates to the synthesis of intermediates for the preparation of compounds of formula (A): wherein n is 2 or 3 and various salt forms of these compounds.

Abstract: The present invention is directed to the improved synthesis of compounds of formula (I) an intermediate compound which is useful in the synthesis of the anticancer agents known as PSA conjugates.

Abstract: The present invention relates to a process for the preparation of a compound of formula (I) wherein Ts is a tosylate group and R is an alkyl group, an unsubstituted phenyl or substituted phenyl ring, or a benzyl or substituted benzyl group; which comprises: (i) cyclising a compound of formula (II) in the presence of a suitable catalyst; and (ii) purifying and collecting the resultant compound of formula (I).

Abstract: The present invention relates to a process for the preparation of morpholine derivatives of formula (I) which are useful as a therapeutic agents.

Abstract: 1

Abstract: The present invention relates to a process for the preparation of mopholine derivatives of formula (I) which are useful as a therapeutic agents.

Abstract: A fastening device comprising a block of plastic material of square or alternative cross section. The block has a threaded bore for the receipt of a bolt which completes the fastening, and additionally, the block has a through slot extending from one end making the block of a U-shape so that it has legs and a base. This configuration is such that the legs can be sprung together so that they can be pushed into the end of a square sectioned cable ladder tube to be connected at right angles to a cable ladder rail, whereupon the legs will spring apart so that a projection on the legs engage in apertures in the tube walls and the block cannot be retracted. To secure the rail to the tube end, the bolt is passed through a hole in the rail and is screwed into the block, which is locked in the tube end. The advantages are pre-insertion of the blocks in the factory and simple assembly of the cable ladder on site, and secure connection joining of the rail and tube ends.

Abstract: The present invention relates to a process for the preparation of substantially pure N-((S)-(-)-.alpha.-methylbenzyl)-3-(S)-(4-fluorophenyl)-1,4-oxazin-2-one hydrochloride, which comprises selectively crystallising the (S,S)-diastereomer as the hydrochloride salt from a mixture of the (S,R)- and (S,S)-diastereomers in an organic solvent, and collecting the resultant crystalline product.

Abstract: The present invention relates to a process for the preparation of a compound of formula (I): ##STR1## wherein R.sup.1 is a C.sub.1-6 alkyl or arylC.sub.1-4 alkyl group; and R.sup.2 is a hydrogen atom, a halogen atom, or a group selected from C.sub.1-6 alkyl, CF.sub.3 or C.sub.1-6 alkoxy substituted by C.sub.1-4 alkoxy; which comprises reacting an anhydrous or hydrated glyoxal of formula (II) with a compound of formula (III): ##STR2## in the presence of an acid.

Abstract: A stand for wine casks having a rectangular block shape and a lower outlet tap. The stand consists of a platform which is elevated above a support surface, and side walls for preventing movement of the cask. A glass support means is removably fitted to the stand.

Abstract: The present invention relates to a process for the preparation of azaindole derivatives of the formula ##STR1## wherein Q is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.1-6 alkoxy, hydroxy, aryl or arylC.sub.1-4 alkyl;one of X, Y and Z is --N.dbd. and the others are --CH.dbd.;R.sup.1 is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.1-6 alkyl substituted by a group selected from aryl or --NR.sup.2 R.sup.3 where R.sup.2 and R.sup.3 each independently represent C.sub.1-4 alkyl, or R.sup.2 and R.sup.3, together with the nitrogen atom to which they are attached, form a 4-7 membered saturated heterocyclic ring, optionally containing in the ring an oxygen or sulphur atom or a group NR.sup.4 where R.sup.4 is C.sub.1-4 alkyl, aryl or arylC.sub.1-4 alkyl; andR.sup.5 is a hydrogen atom or a group selected from C.sub.1-6 alkyl or aryl.

Abstract: The present invention provides a process for the preparation of substantially pure N-benzyl-3-(S)-(4-fluorophenyl)-1,4-oxazin-2-one which comprises:(i) contacting racemic N-benzyl-3-(4-fluorophenyl)-1,4-oxazin-2-one with (-)-3-bromocamphor-8-sulphonic acid (hereinafter referred to as (-)-3-BCS) in the presence of a racemising agent;(ii) collecting the resultant crystalline (-)-3-BCS salt of N-benzyl-3-(S)-(4-fluorophenyl)-1,4-oxazin-2-one; and(iii) liberating the free base of N-benzyl-3-(S)-(4-fluorophenyl)-1,4-oxazin-2-one by treatment of the (-)-3-BCS salt collected in step (ii) with aqueous base.

Abstract: Aluminum base alloys, having improved properties as regards mechanical working treatments, according to the invention are characterized by a content of 0.5 - 10.0 wt. % iron, without or with a very small content (up to 0.1 wt. %) of Li or Na or Sr or Ba. The alloy has a microstructure comprising a substantial portion of refined Al.sub.3 Fe and/or very fine Al.sub.6 Fe.