Abstract: The invention relates to a ferritic alloy composition. In one aspect, the ferritic alloy composition comprises about 16 to 20 wt. % Cr, about 7 to 11 wt. % Mo, and the balance Fe. In another aspect, the ferritic composition comprises about 10 to 14 wt. % Cr, about 7 to 11 wt. % Mo or about 10 to 20 wt. % W, and the balance Fe.

Abstract: A coupon for measuring the corrosion rates of metals in a hostile environment, including two or more thin-film resistive conductors formed on a substrate and positioned in close physical proximity so that they are subjected to essentially the same physical environment. One or more of the thin-film resistive conductors is directly exposed to the potentially corrosive environment while at least one of the thin-film elements is protected from the corrosive nature of the environment. The element or elements that are protected from corrosion are either shielded from the corrosive effects of the environment by the presence of a thermally thin protective layer or by being isolated from the corrosive environment while being maintained at essentially the same temperature as the elements exposed to the corrosive environment. The invention is also directed to a system for measuring the corrosion rate by measuring the change in resistance of the exposed conductor in comparison to the protected chamber.

Abstract: An antigen which produces immunity against homologous or heterologous challenge with babesia of cattle. The antigen is immunoreactive with a monoclonal antibody or polyclonal antisera recognising a protein located on the surface of babesia-infected erythrocytes and within a spherical or mitochondrion like organelle. The antigen can be prepared by (i) preparing nucleic acids from babesia infected erythrocytes depleted of leucocytes; (ii) forming a cDNA or genomic library from nucleic acids obtained in step (i); (iii) screening said library formed in step (ii) with a suitable probe to identify clones of interest; and thus providing DNA inserts for an expression vector which may be used to transform an appropriate host; (iv) obtaining a recombinant polypeptide from said transformed hosts which is protective against babesiosis.

Abstract: Cis .alpha.,.alpha./.beta., .beta.-3-amino-4-[2-(2-furyl)eth-1-yl]-1-methoxycarbonylmethyl-azetidin-2- one is resolved via (-)-2,3:4,6-di-O-isopropylidene-2-keto-L-gulonic acid hydrate (DAG).

Abstract: Cis .alpha..alpha./.beta..beta.-3-amino-[2-(2-furyl)eth-1-yl]-1-methoxycarbony lmethyl-azetidin-2-one is resolved via optically active tartaric acid.

Abstract: A high temperature, oxidation resistant alloy useful in high temperature, oxidizing environments such as those encountered in gas turbines, advanced jet engines, high temperature furnaces and glass melting and processing equipment, among others.The alloy is characterized by selecting a refractory alloy from the group consisting of molybdenum, tungsten, niobium and tantalum having dispersed therein a second phase additive of titanium nitride and a third phase additive of aluminum and titanium. Alternatively, the refractory metals may be molybdenum or tungsten and the second phase additive and third phase additive may be silicon nitride and silicon, or chromium nitride and chromium respectively.

Abstract: A method of preparation of babesiosis antigen including the steps of: (i) forming a crude babesiosis antigenic fraction which is derived from a lysate of Babesia infected erythrocytes or soluble fraction thereof; (ii) forming monoclonal antibody to said babesiosis antigen fraction by cloning antibody producing cells from an animal having been administered thereto said babesiosis antigen fraction; (iii) absorbing said monoclonal antibody onto an absorbent and passing said babesiosis antigenic fraction through said absorbent whereby an antigen specific to said monoclonal antibody may be bound thereto; and (iv) separating the specific antigen from the monoclonal antibody.

Abstract: A process for preparing a C.sub.3 -C.sub.8 alkyl cyanoformate derivative employing a liquid-liquid phase transfer catalysis conducted at low temperatures.

Abstract: This invention relates to a method of preparation of a babesiosis vaccine which involves treating a suspension of Babesia infected erythrocytes. The erythrocytes are disintegrated, separated into soluble and insoluble fractions and subsequently fibrinogen and contaminated Babesia antigen is removed from the soluble fraction. The residual soluble fraction is then combined with an adjuvant to form the babesiosis vaccine. The invention also includes within its scope a vaccine derived from the abovementioned method and a method of administration of the vaccine to cattle.

Abstract: The silylated and enamine protected D-3- or 4-hydroxyphenylglycine as the sodium salt of the formula ##STR1## wherein A is methyl or ethyl, are crystalline intermediates useful in a new process for the acylation of heterocyclicthiomethyl-substituted cephalosporin nuclei, e.g. 7-amino-3-(5-methyl-1,3,4-thiadiazole-2-ylthiomethyl)-3-cephem-4-carboxyli c acid and 7-amino-3-(1-methyl-1H-tetrazole-5-ylthiomethyl)-3-cephem-4-carboxylic acid.

Abstract: N,N'-Dichlorobicyclo[2.2.2]oct-7-ene-2,3,5,6-tetracarboxylic-2,3,5,6-diimid e is useful as a reagent in reactions which require a source of positive chlorine.

Abstract: The silylated and enamine protected D-3- or 4-hydroxyphenylglycine as the sodium salt of the formula ##STR1## wherein A is methyl or ethyl, are crystalline intermediates useful in a new process for the acylation of heterocyclic-thiomethyl-substituted cephalosporin nuclei, e.g. 7-amino-3-(5-methyl-1,3,4-thiadiazole-2-ylthiomethyl)-3-cephem-4-carboxyli c acid and 7-amino-3-(1-methyl-1H-tetrazole-5-ylthiomethyl)-3-cephem-4-carboxylic acid.

Abstract: 4-Desacetoxy-4-oxovinblastine, prepared by oxidation of 4-desacetylvinblastine, useful as an intermediate.

Abstract: A 3-methoxymethylcephalosporin acid is prepared by reacting a 3-hydroxymethylcephalosporin acid with a reagent selected from the group consisting of trifluoroacetic anhydride, phosphorus trichloride, phosphorus oxychloride, and thionyl chloride, and reacting the resulting intermediate with methanol.

Abstract: 6-APA, 7-ACA and 7-ADCA esters are reacted with benzaldehyde, acetophenone or substituted derivatives thereof providing imines which react in the presence of a strong base such as sodium hydride or lithium diisopropyl amide with a C.sub.2 -C.sub.5 alkanoyl halide, 2,2,2-trichloroethoxycarbonyl chloride, a benzoyl halide, a C.sub.1 -C.sub.4 alkoxycarbonyl chloride or a methoxymethyl halide to afford C.sub.6 and C.sub.7 substituted .beta.-lactam imines via acylation or methoxymethylation. The .beta.-lactam substituted imines are reacted with a carbonyl reagent, e.g. Girard's reagent T to provide a C.sub.6 substituted 6-APA ester or a C.sub.7 substituted 7-ACA or 7-ADCA ester which is acylated to provide a 6-acylamido-6-substituted penicillin or a 7-acyl-amide-7-substituted cephalosporin.

Abstract: This invention is addressed to a new and improved method for the preparation of 3-alkylthiomethyl-7-acylamido cephalosporins in which a 3-alkanoyloxymethyl-7-acylamido cephalosporin is reacted with an alkane thiol in aqueous medium in the presence of certain inorganic salts to produce the desired 3-alkylthiomethyl product in significantly improved yields.