Patents by Inventor Ian Gilbert

Ian Gilbert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210101877
    Abstract: The present invention relates to a novel class of chromene-2-carboxamide compounds inhibitors of general formula I wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and their use as anti-infective agents in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.
    Type: Application
    Filed: October 13, 2020
    Publication date: April 8, 2021
    Inventors: Barbara FORTE, Neil NORCROSS, Chimed JANSEN, Beatriz BARAGANA, Ian GILBERT, Laura CLEGHORN, Susan DAVIS, Christopher WALPOLE
  • Patent number: 10520539
    Abstract: A system for detecting and indicating partial discharges and voltage. The system allows capturing signals from the electric power system and/or the electrical equipment thereof, and detecting and indicating the presence or absence of partial discharges and voltage, which allows carrying out a quick and simple inspection in order to prevent faults in the distribution elements, preventing risks and performing suitable installation maintenance.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: December 31, 2019
    Assignee: Ormazabal Protection & Automation, S.L.U.
    Inventors: Juan Antonio Sanchez Ruiz, Jagoba Perez Martinez, Jose Maria Rua Sanchez, Ian Gilbert, Aritz Hurtado Vicuña, Patrick Mulroy
  • Publication number: 20190225592
    Abstract: The present invention relates to a novel class of chromene-2-carboxamide compounds inhibitors of general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and their use as anti-infective agents in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.
    Type: Application
    Filed: June 20, 2017
    Publication date: July 25, 2019
    Inventors: Barbara FORTE, Neil NORCROSS, Chimed JANSEN, Beatriz BARAGANA, Ian GILBERT, Laura CLEGHORN, Susan DAVIS, Christopher WALPOLE
  • Patent number: 10065965
    Abstract: A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT) and leishmaniasis, particularly visceral leishmaniasis (VL).
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: September 4, 2018
    Assignees: GlaxoSmithKline Intellectual Property Development Limited, The University of Dundee
    Inventors: Stephen Brand, Elisabet Viayna Gaza, Ian Gilbert, Eun Jung Ko, Maria Marco Martin, Timothy James Miles, Lars Henrik Sandberg, Michael George Thomas
  • Publication number: 20180156857
    Abstract: A system for detecting and indicating partial discharges and voltage. The system allows capturing signals from the electric power system and/or the electrical equipment thereof, and detecting and indicating the presence or absence of partial discharges and voltage, which allows carrying out a quick and simple inspection in order to prevent faults in the distribution elements, preventing risks and performing suitable installation maintenance.
    Type: Application
    Filed: December 5, 2017
    Publication date: June 7, 2018
    Inventors: Juan Antonio Sanchez Ruiz, Jagoba Perez Martinez, Jose Maria Rua Sanchez, Ian Gilbert, Aritz Hurtado Vicuña, Patrick Mulroy
  • Publication number: 20180141949
    Abstract: A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT) and leishmaniasis, particularly visceral leishmaniasis (VL).
    Type: Application
    Filed: May 26, 2016
    Publication date: May 24, 2018
    Inventors: Stephen BRAND, Elisabet Viayna GAZA, Ian GILBERT, Eun Jung KO, Maria MARCO MARTIN, Timothy James MILES, Lars Henrik SANDBERG, Michael George THOMAS
  • Patent number: 9828346
    Abstract: The present invention relates to N-heterocyclic sulphonamide compounds, in particular pyrazole sulphonamide compounds, and their use as N-myristoyl transferase inhibitors.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: November 28, 2017
    Assignee: University of Dundee
    Inventors: Stephen Brand, Paul Wyatt, Stephen Thompson, Victoria Smith, Tracy Bayliss, Justin Harrison, Neil Norcross, Laura Cleghorn, Ian Gilbert, Ruth Brenk
  • Publication number: 20170114029
    Abstract: The invention provides compounds of the formula: wherein L1 and L2 are independently selected from O and S; R1 is C3-C6 straight or branched alkyl, C3-C7cycloalkyl, C5-C7cycloalkenyl, adamantly, phenyl or saturated heterocyclyl, any of which being optionally substituted; R2 is H, methyl or ethyl; R5 is NRxCORy, NRxRy, CH2COCH3, CH2C?N, or a 5- or 6-membered heteroaryl group which is optionally substituted; X, Y and Z are independently N or CH; Rx is independently H or C1-C4alkyl; Ry is independently H, CrC4alkyl, phenyl or benzyl, either of which is optionally substituted; n is 0-3; salts, hydrates and N-oxides, wherein the optional substituents are further defined in the claims. The compounds have utility in the prophylaxis or treatment of trypanosomal diseases, such as T. cruzi (Chagas disease).
    Type: Application
    Filed: June 9, 2015
    Publication date: April 27, 2017
    Inventors: Pia KAHNBERG, Nils-Gunnar JOHANSSON, Shahienaz HAMPTON, Justin HARRISON, Sandipan SARKAR, Dolores GONZALES, Ian GILBERT
  • Publication number: 20160060224
    Abstract: The present invention relates to N-heterocyclic sulphonamide compounds, in particular pyrazole sulphonamide compounds, and their use as N-myristoyl transferase inhibitors.
    Type: Application
    Filed: August 31, 2015
    Publication date: March 3, 2016
    Applicant: UNIVERSITY OF DUNDEE
    Inventors: Stephen Brand, Paul Wyatt, Stephen Thompson, Victoria Smith, Tracy Bayliss, Justin Harrison, Neil Norcross, Laura Cleghorn, Ian Gilbert, Ruth Brenk
  • Patent number: 9156811
    Abstract: The present invention relates to N-heterocyclic sulphonamide compounds, in particular pyrazole sulphonamide compounds, and their use as N-myristoyl transferase inhibitors.
    Type: Grant
    Filed: August 29, 2009
    Date of Patent: October 13, 2015
    Assignee: Univeristy of Dundee
    Inventors: Stephen Brand, Paul Wyatt, Stephen Thompson, Victoria Smith, Tracy Bayliss, Justin Harrison, Neil Norcross, Laura Cleghorn, Ian Gilbert, Ruth Brenk
  • Patent number: 9133758
    Abstract: A split-cycle air hybrid engine includes a rotatable crankshaft. A compression piston is slidably received within a compression cylinder and operatively connected to the crankshaft. An expansion piston is slidably received within an expansion cylinder and operatively connected to the crankshaft. A crossover passage interconnects the compression and expansion cylinders. The crossover passage includes a crossover compression (XovrC) valve and a crossover expansion (XovrE) valve defining a pressure chamber therebetween. An air reservoir is operatively connected to the crossover passage. An air reservoir valve selectively controls air flow into and out of the air reservoir. In an Air Expander and Firing (AEF) mode of the engine, the engine has a residual expansion ratio at XovrE valve closing of 15.7 to 1 or greater, and more preferably in the range of 15.7 to 1 and 40.8 to 1.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: September 15, 2015
    Inventors: Riccardo Meldolesi, Nicholas Badain, Ian Gilbert
  • Patent number: 9079895
    Abstract: The invention relates to morpholino-derivatives according to Formula (I) or stereoisomers or pharmaceutically acceptable salts or solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, m and n are as defined in the specification. The compounds are antagonists, reverse agonists or agonists of G-protein coupled receptors, such as dopamine D4 and 5HT1a. The inventions also relates to pharmaceutical compositions comprising the compounds and methods involving the compounds and compositions. The compounds and compositions of the invention may in particular be used in the treatment of diseases and disorders, such as neurological and neurodegenerative diseases; or as lead compounds for the design and selection of further therapeutic compounds.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: July 14, 2015
    Assignee: University of Dundee
    Inventors: Jeremy Besnard, Andrew Lee Hopkins, Ian Gilbert, Gian Filippo Ruda, Keren Abecassis
  • Publication number: 20140158102
    Abstract: A split-cycle air hybrid engine includes a rotatable crankshaft. A compression piston is slidably received within a compression cylinder and operatively connected to the crankshaft. An expansion piston is slidably received within an expansion cylinder and operatively connected to the crankshaft. A crossover passage interconnects the compression and expansion cylinders. The crossover passage includes a crossover compression (XovrC) valve and a crossover expansion (XovrE) valve defining a pressure chamber therebetween. An air reservoir is operatively connected to the crossover passage. An air reservoir valve selectively controls air flow into and out of the air reservoir. In an Air Expander and Firing (AEF) mode of the engine, the engine has a residual expansion ratio at XovrE valve closing of 15.7 to 1 or greater, and more preferably in the range of 15.7 to 1 and 40.8 to 1.
    Type: Application
    Filed: February 13, 2014
    Publication date: June 12, 2014
    Applicant: SCUDERI GROUP, INC.
    Inventors: Riccardo Meldolesi, Nicholas Badain, Ian Gilbert
  • Publication number: 20140148452
    Abstract: The invention relates to morpholino-derivatives according to Formula (I) or stereoisomers or pharmaceutically acceptable salts or solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, m and n are as defined in the specification. The compounds are antagonists, reverse agonists or agonists of G-protein coupled receptors, such as dopamine D4 and 5HT1a. The inventions also relates to pharmaceutical compositions comprising the compounds and methods involving the compounds and compositions. The compounds and compositions of the invention may in particular be used in the treatment of diseases and disorders, such as neurological and neurodegenerative diseases; or as lead compounds for the design and selection of further therapeutic compounds.
    Type: Application
    Filed: November 20, 2013
    Publication date: May 29, 2014
    Applicant: University of Dundee
    Inventors: Jeremy Besnard, Andrew Lee Hopkins, Ian Gilbert, Gian Filippo Ruda, Keren Abecassis
  • Patent number: 8689745
    Abstract: A split-cycle air-hybrid engine includes a rotatable crankshaft. A compression piston is slidably received within a compression cylinder and operatively connected to the crankshaft. An expansion piston is slidably received within an expansion cylinder and operatively connected to the crankshaft. A crossover passage interconnects the compression and expansion cylinders. The crossover passage includes a crossover compression (XovrC) valve and a crossover expansion (XovrE) valve defining a pressure chamber therebetween. An air reservoir is operatively connected to the crossover passage. An air reservoir valve selectively controls air flow into and out of the air reservoir. The engine is operable in an Air Expander and Firing (AEF) mode. In the AEF mode, the pressure in the air reservoir is greater than or equal to approximately 5 bar absolute, preferably greater than or equal to approximately 7 bar absolute, and more preferably greater than or equal to approximately 10 bar absolute.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: April 8, 2014
    Assignee: Scuderi Group, Inc.
    Inventors: Riccardo Meldolesi, Nicholas Badain, Ian Gilbert
  • Patent number: 8677953
    Abstract: A split-cycle air hybrid engine includes a rotatable crankshaft. A compression piston is slidably received within a compression cylinder and operatively connected to the crankshaft. An expansion piston is slidably received within an expansion cylinder and operatively connected to the crankshaft. A crossover passage interconnects the compression and expansion cylinders. The crossover passage includes a crossover compression (XovrC) valve and a crossover expansion (XovrE) valve defining a pressure chamber therebetween. An air reservoir is operatively connected to the crossover passage. An air reservoir valve selectively controls air flow into and out of the air reservoir. In an Air Expander and Firing (AEF) mode of the engine, the engine has a residual expansion ratio at XovrE valve closing of 15.7 to 1 or greater, and more preferably in the range of 15.7 to 1 and 40.8 to 1.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: March 25, 2014
    Assignee: Scuderi Group, Inc.
    Inventors: Riccardo Meldolesi, Nicholas Badain, Ian Gilbert
  • Patent number: 8590497
    Abstract: A split-cycle air-hybrid engine includes a rotatable crankshaft. A compression piston is slidably received within a compression cylinder and operatively connected to the crankshaft. An expansion piston is slidably received within an expansion cylinder and operatively connected to the crankshaft. An exhaust valve selectively controls gas flow out of the expansion cylinder. A crossover passage interconnects the compression and expansion cylinders. The crossover passage includes a crossover compression (XovrC) valve and a crossover expansion (XovrE) valve therein. An air reservoir is operatively connected to the crossover passage. An air reservoir valve selectively controls air flow into and out of the air reservoir. In an Air Compressor (AC) mode of the engine, the XovrE valve is kept closed during an entire rotation of the crankshaft, and the exhaust valve is kept open for at least 240 CA degrees of the same rotation of the crankshaft.
    Type: Grant
    Filed: March 14, 2011
    Date of Patent: November 26, 2013
    Assignee: Scuderi Group, Inc.
    Inventors: Riccardo Meldolesi, Nicholas Badain, Ian Gilbert
  • Patent number: 8539920
    Abstract: The present invention provides a valve actuation system comprising a valve train for actuating a valve, the valve train including actuating elements and a valve lash, and a valve lash adjustment system for adjusting the valve lash, wherein the valve train and the valve lash adjustment system do not share any common actuating elements.
    Type: Grant
    Filed: January 20, 2010
    Date of Patent: September 24, 2013
    Assignee: Scuderi Group, Inc.
    Inventors: Riccardo Meldolesi, Clive Lacy, Anthony Perkins, Ian Gilbert
  • Patent number: 8534250
    Abstract: The present invention provides a valve actuation system comprising a valve train for actuating a valve, the valve train including actuating elements and a valve lash, and a valve lash adjustment system for adjusting the valve lash, wherein the valve train and the valve lash adjustment system do not share any common actuating elements.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: September 17, 2013
    Assignee: Scuderi Group, Inc.
    Inventors: Riccardo Meldolesi, Clive Lacy, Anthony Perkins, Ian Gilbert
  • Publication number: 20110312921
    Abstract: The present invention relates to N-heterocyclic sulphonamide compounds, in particular pyrazole sulphonamide compounds, and their use as N-myristoyl transferase inhibitors.
    Type: Application
    Filed: August 29, 2009
    Publication date: December 22, 2011
    Inventors: Stephen Brand, Paul Wyatt, Stephen Thompson, Victoria Smith, Tracy Bayliss, Justin Harrison, Neil Norcross, Laura Cleghorn, Ian Gilbert, Ruth Brenk