Patents by Inventor Ian H. Holmes

Ian H. Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ADENO-ASSOCIATED VIRUS VARIANTS AND METHODS OF USE THEREOF
    Publication number: 20210147876
    Abstract: The present disclosure provides recombinant adeno-associated virus (rAAV) virions comprising a variant AAV capsid protein, e.g., an AAV capsid protein derived from an ancestral AAV capsid protein amino acid sequence. An rAAV virion of the present disclosure can exhibit greater infectivity of a target cell. The present disclosure also provides methods of delivering a gene product to a target cell in an individual by administering to the individual an rAAV of the present disclosure. The present disclosure also provides methods of generating rAAV virions that have a variant AAV capsid protein derived from an ancestral AAV capsid protein amino acid sequence.
    Type: Application
    Filed: November 30, 2020
    Publication date: May 20, 2021
    Inventors: David S. Ojala, Jorge Santiago-Ortiz, Oscar Westesson, David V. Schaffer, Ian H. Holmes, John Weinstein
  • Adeno-associated virus variants and methods of use thereof
    Patent number: 10883117
    Abstract: The present disclosure provides recombinant adeno-associated virus (rAAV) virions comprising a variant AAV capsid protein, e.g., an AAV capsid protein derived from an ancestral AAV capsid protein amino acid sequence. An rAAV virion of the present disclosure can exhibit greater infectivity of a target cell. The present disclosure also provides methods of delivering a gene product to a target cell in an individual by administering to the individual an rAAV of the present disclosure. The present disclosure also provides methods of generating rAAV virions that have a variant AAV capsid protein derived from an ancestral AAV capsid protein amino acid sequence.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: January 5, 2021
    Assignee: The Regents of the University of California
    Inventors: David S. Ojala, Jorge Santiago-Ortiz, Oscar Westesson, David V. Schaffer, Ian H. Holmes, John Weinstein
  • ADENO-ASSOCIATED VIRUS VARIANTS AND METHODS OF USE THEREOF
    Publication number: 20180066285
    Abstract: The present disclosure provides recombinant adeno-associated virus (rAAV) virions comprising a variant AAV capsid protein, e.g., an AAV capsid protein derived from an ancestral AAV capsid protein amino acid sequence. An rAAV virion of the present disclosure can exhibit greater infectivity of a target cell. The present disclosure also provides methods of delivering a gene product to a target cell in an individual by administering to the individual an rAAV of the present disclosure. The present disclosure also provides methods of generating rAAV virions that have a variant AAV capsid protein derived from an ancestral AAV capsid protein amino acid sequence.
    Type: Application
    Filed: March 23, 2016
    Publication date: March 8, 2018
    Inventors: David S. Ojala, Jorge Santiago-Ortiz, Oscar Westesson, David V. Schaffer, Ian H. Holmes, John Weinstein
  • DNA sequence and amino acid sequence encoding the human rotavirus major outer capsid glycoprotein
    Patent number: 5395759
    Abstract: A material being a dsRNA gene segment coding for the major outer capsid glycoprotein of a rotavirus.
    Type: Grant
    Filed: February 1, 1990
    Date of Patent: March 7, 1995
    Assignee: The University of Melbourne
    Inventors: Ian H. Holmes, Michael L. Dyall-Smith
  • Recombinant human rotavirus VP7 serotype 4
    Patent number: 5332658
    Abstract: A human rotavirus gene encoding the major outer capsid glycoprotein (VP7) of the human rotavirus serotype 4 or a portion or sub-unit thereof. Expression vectors containing such a gene and expressing all or part of VP7 protein of human rotavirus serotype 4. Polyeptides corresponding to all or part of the VP7 protein of human rotavirus serotype 4 and vaccines containing such polypeptides.
    Type: Grant
    Filed: June 16, 1992
    Date of Patent: July 26, 1994
    Assignee: The University of Melbourne
    Inventors: Michael L. Dyall-Smith, Chris Hum, Ian H. Holmes, Michael A. Johnson, Peter R. Reeves