Patents by Inventor Ian Holmes
Ian Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20260109705Abstract: Described herein are compositions and methods for the treatment or prevention of dermal or ocular surface disorders, such as those associated with bacterial and/or parasitic infections. Bacterial and/or parasitic infections include mites (e.g., demodex), worms, protozoa (e.g., amoeba (e.g., acanthamoeba or cryptosporidiosis)), onchocerciasis, lice, scabies, nematodes, or chlamydia. Said compositions and methods comprise compounds which demonstrate immunological, keratolytic, anti-histamine, anti-inflammatory, and/or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.Type: ApplicationFiled: December 14, 2023Publication date: April 23, 2026Inventors: Ian HOLMES, Yair ALSTER, Charles BOSWORTH, Omer RAFAELI, Marc GLEESON, Robert M. BURK, Mark Richard STEWART, Jonathan DUNN, Alexander James NICHOLLS, Sophie Caroline WILLIAMS
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Publication number: 20260055110Abstract: Described herein are compositions and methods for the treatment or prevention of dermal or ocular surface disorders. Ocular surface disorders include ocular allergy, dry eye disease, ocular manifestation of graft versus host disease and other inflammatory and/or infectious diseases of the (e.g., anterior) surface of the eye(s). Said compositions and methods comprise keratolytic conjugates which demonstrate immunological, keratolytic, anti-inflammatory, and/or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.Type: ApplicationFiled: October 19, 2022Publication date: February 26, 2026Inventors: Ian HOLMES, Yair ALSTER, Hila BARASH, Charles BOSWORTH, Omer RAFAELI, Robert M. BURK, Marc GLEESON, Mark Richard STEWART, Jonathan DUNN, Soultana KATSINA, Elisa PILEGGI, Alexander James NICHOLLS
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Patent number: 12468280Abstract: In a production line where various operations have to be performed on a unit that is conveyed through or assembled in the line, a control system for a set of actuators is provided that operates in discrete steps to carry out movement in a machine and is required to synchronize at points in speed and position. A controller is provided for each actuator, and a coordinator configured to determine or receive the position of the actuators and to receive or generate data concerning a waypoint, being positions and corresponding speeds for the actuators. The controllers are configured to change the speed of the actuators, and the coordinator starts the movement of at least one actuator on the basis of a point reached by another actuator, so as to achieve the desired synchronization.Type: GrantFiled: May 20, 2021Date of Patent: November 11, 2025Assignee: MAREL LIMITEDInventor: Ian Holmes
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Publication number: 20250066416Abstract: The present invention relates to TLR2 agonist compounds and their compositions, and the use of such compounds and compositions in the prevention and/or treatment of respiratory infections, or diseases or conditions associated with viral or bacterial infections.Type: ApplicationFiled: October 30, 2024Publication date: February 27, 2025Inventors: David Jackson, Ian Holmes, Weiguang Zeng, Christophe Demaison
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Publication number: 20250042931Abstract: Described herein are compositions and methods for the treatment or prevention of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious diseases of the anterior surface of the eye(s). Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.Type: ApplicationFiled: October 10, 2024Publication date: February 6, 2025Inventors: Ian HOLMES, Yair ALSTER, Hila BARASH, Charles BOSWORTH, Omer RAFAELI, Robert M. BURK, Marc GLEESON, Mark Richard STEWART, Jonathan DUNN, Alexander James NICHOLLS
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Patent number: 12195557Abstract: The present invention relates to TLR2 agonist compounds and their compositions, and the use of such compounds and compositions in the prevention and/or treatment of respiratory infections, or diseases or conditions associated with viral or bacterial infections.Type: GrantFiled: December 21, 2018Date of Patent: January 14, 2025Assignee: AXELIA ONCOLOGY PTY LTDInventors: David Jackson, Ian Holmes, Weiguang Zeng, Christophe Demaison
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Patent number: 12157777Abstract: The present invention relates to TLR2 agonist compounds and their compositions, and the use of such compounds and compositions in the prevention and/or treatment of respiratory infections, or diseases or conditions associated with viral or bacterial infections.Type: GrantFiled: December 21, 2018Date of Patent: December 3, 2024Assignee: AXELIA ONCOLOGY PTY LTDInventors: David Jackson, Ian Holmes, Weiguang Zeng, Christophe Demaison
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Patent number: 12017979Abstract: The present invention relates to TLR2 agonist compounds and their compositions, and the use of such compounds and compositions in the prevention and/or treatment of respiratory infections, or diseases or conditions associated with viral or bacterial infections.Type: GrantFiled: March 23, 2023Date of Patent: June 25, 2024Assignee: ENA Respiratory Pty LtdInventors: Ian Holmes, Weiguang Zeng, David Jackson, Christophe Demaison, Grant McLachlan
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Publication number: 20240158375Abstract: Described herein are compositions and methods for the treatment or prevention of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious diseases of the anterior surface of the eye(s). Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.Type: ApplicationFiled: October 20, 2021Publication date: May 16, 2024Inventors: Ian HOLMES, Yair ALSTER, Hila BARASH, Charles BOSWORTH, Omer RAFAELI, Robert M. BURK, Marc GLEESON, Mark Richard STEWART, Soultana KATSINA
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Publication number: 20230399317Abstract: Described herein are compositions and methods for the treatment or prevention of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious diseases of the anterior surface of the eye(s). Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.Type: ApplicationFiled: October 20, 2021Publication date: December 14, 2023Inventors: Charles BOSWORTH, Mark Richard STEWART, Hila BARASH, Nicholas Andrew CHAPMAN, Robert M. BURK, Ian HOLMES, Marc GLEESON, Yair ALSTER, Omer RAFAELI, Jonathan DUNN
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Publication number: 20230357207Abstract: Described herein are compositions and methods for the treatment of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious disease of the anterior surface of the eye. Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.Type: ApplicationFiled: March 8, 2023Publication date: November 9, 2023Inventors: Ian HOLMES, Yair ALSTER, Hila BARASH, Charles BOSWORTH, Omer RAFAELI, Marc GLEESON, Mark Richard STEWART, Robert M. BURK, Jonathan DUNN, Nicholas CHAPMAN
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Publication number: 20230348517Abstract: Described herein are compositions and methods for the treatment of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory/infections disease of the anterior surface of the eye. Said compositions and methods comprise keratolytic conjugate which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eye, ocular surface or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.Type: ApplicationFiled: March 6, 2023Publication date: November 2, 2023Inventors: Ian HOLMES, Yair ALSTER, Hila BARASH, Charles BOSWORTH, Omer RAFAELI, Marc GLEESON, Mark Richard STEWART, Jonathan DUNN
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Publication number: 20230288901Abstract: In a production line where various operations have to be performed on a unit that is conveyed through or assembled in the line, a control system for a set of actuators is provided that operates in discrete steps to carry out movement in a machine and is required to synchronize at points in speed and position. A controller is provided for each actuator, and a coordinator configured to determine or receive the position of the actuators and to receive or generate data concerning a waypoint, being positions and corresponding speeds for the actuators. The controllers are configured to change the speed of the actuators, and the coordinator starts the movement of at least one actuator on the basis of a point reached by another actuator, so as to achieve the desired synchronization.Type: ApplicationFiled: May 20, 2021Publication date: September 14, 2023Inventor: Ian HOLMES
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Publication number: 20230257345Abstract: The present invention relates to TLR2 agonist compounds and their compositions, and the use of such compounds and compositions in the prevention and/or treatment of respiratory infections, or diseases or conditions associated with viral or bacterial infections.Type: ApplicationFiled: March 23, 2023Publication date: August 17, 2023Inventors: Ian Holmes, Weiguang Zeng, David Jackson, Christophe Demaison, Grant McLachlan
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Patent number: 11643429Abstract: Described herein are compositions and methods for the treatment of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory/infections disease of the anterior surface of the eye. Said compositions and methods comprise keratolytic conjugate which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eye, ocular surface or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.Type: GrantFiled: April 5, 2021Date of Patent: May 9, 2023Assignee: AZURA OPHTHALMICS LTD.Inventors: Ian Holmes, Yair Alster, Hila Barash, Charles Bosworth, Omer Rafaeli, Marc Gleeson, Mark Richard Stewart, Jonathan Dunn
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Patent number: 11634411Abstract: Described herein are compositions and methods for the treatment of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious disease of the anterior surface of the eye. Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.Type: GrantFiled: December 4, 2020Date of Patent: April 25, 2023Assignee: AZURA OPHTHALMICS LTD.Inventors: Ian Holmes, Yair Alster, Hila Barash, Charles Bosworth, Omer Rafaeli, Marc Gleeson, Mark Richard Stewart, Robert M. Burk, Jonathan Dunn, Nicholas Chapman
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Publication number: 20220388950Abstract: The present invention relates to TLR2 agonist compounds and their compositions, and the use of such compounds and compositions in the prevention and/or treatment of respiratory infections, or diseases or conditions associated with viral or bacterial infections.Type: ApplicationFiled: June 26, 2020Publication date: December 8, 2022Inventors: Ian Holmes, Weiguang Zeng, David Jackson, Christophe Demaison, Grant Mclachlan
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Publication number: 20220332748Abstract: Described herein are compositions and methods for the treatment or prevention of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious diseases of the anterior surface of the eye(s). Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.Type: ApplicationFiled: April 5, 2021Publication date: October 20, 2022Inventors: Ian HOLMES, Yair ALSTER, Hila BARASH, Charles BOSWORTH, Omer RAFAELI, Robert M. BURK, Marc GLEESON, Mark Richard STEWART, Jonathan DUNN, Alexander James NICHOLLS
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Publication number: 20220332749Abstract: Described herein are compositions and methods for the treatment or prevention of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious diseases of the anterior surface of the eye(s). Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.Type: ApplicationFiled: June 15, 2022Publication date: October 20, 2022Inventors: Ian HOLMES, Yair ALSTER, Hila EPSTEIN-BARASH, Charles BOSWORTH, Omer RAFAELI, Robert M. BURK, Marc GLEESON, Mark Richard STEWART, Jonathan DUNN, Alexander James NICHOLLS
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Patent number: 11459351Abstract: Described herein are compositions and methods for the treatment or prevention of ocular surface disorders including meibomian gland dysfunction, blepharitis, dry eye disease and other inflammatory and/or infectious diseases of the anterior surface of the eye(s). Said compositions and methods comprise keratolytic conjugates which demonstrate keratolytic activity, and anti-inflammatory or other desirable activities. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from ocular surface disorders.Type: GrantFiled: April 5, 2021Date of Patent: October 4, 2022Assignee: AZURA OPHTHALMICS LTD.Inventors: Ian Holmes, Yair Alster, Hila Barash, Charles Bosworth, Omer Rafaeli, Robert M. Burk, Marc Gleeson, Mark Richard Stewart, Jonathan Dunn, Alexander James Nicholls