Patents by Inventor Ian J. Caley

Ian J. Caley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alphavirus replicon vector systems
    Patent number: 7425337
    Abstract: The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication competent alphavirus particles, as determined by passage on cells in culture. The compositions include helper and replicon nucleic acid molecules that can further reduce the predicted frequency for formation of replication-competent virus and can optimize manufacturing strategies and costs.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: September 16, 2008
    Assignee: AlphaVax, Inc.
    Inventors: Jonathan F. Smith, Kurt I. Kamrud, Jonathan O. Rayner, Sergey A. Dryga, Ian J. Caley
  • Alphavirus replicon vector systems
    Patent number: 7045335
    Abstract: The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication-competent alphavirus particles, as determined by passage on cells in culture. The compositions include helper and replicon nucleic acid molecules that can further reduce the predicted frequency for formation of replication-competent virus and can optimize manufacturing strategies and costs.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: May 16, 2006
    Assignee: Alphavax, Inc.
    Inventors: Jonathan F. Smith, Kurt I. Kamrud, Jonathan O. Rayner, Sergey A. Dryga, Ian J. Caley
  • Alphavirus replicon vector systems
    Publication number: 20030119182
    Abstract: The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication-competent alphavirus particles, as determined by passage on cells in culture. The compositions include helper and replicon nucleic acid molecules that can further reduce the predicted frequency for formation of replication-competent virus and can optimize manufacturing strategies and costs.
    Type: Application
    Filed: September 6, 2002
    Publication date: June 26, 2003
    Inventors: Jonathan F. Smith, Kurt I. Kamrud, Jonathan O. Rayner, Sergey A. Dryga, Ian J. Caley