Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, PCSK9, or a pharmaceutically acceptable salt, solvate, prodrug or polymorph thereof, and to compositions and formulations comprising such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I): wherein A, D and Q are described herein.

Abstract: A computer implemented method is disclosed relating to the design of electronic circuits and systems. In some examples, a graphical user interface is utilized to receive first information relating to a requested electronic circuit. The first information includes a selected type of electronic circuit and one or more operating criteria relating to requested fundamental functionality of the selected type of electronic circuit. Second information is also received, relating to requested secondary attributes of a hypothetical candidate electronic circuit that satisfies the first information. In response, a set of candidate circuit architectures are displayed satisfying the first information, as well as a visualization of how each of the candidate circuit architectures relates to the second information.

Abstract: A disk drive apparatus determines a pattern of bits of a data signal applied to a magnetic write transducer of a heat-assisted magnetic recording apparatus. The magnetic write transducer applies a magnetic field to a recording medium in response to the data signal. A laser power signal is applied to a laser that heats the recording medium while the magnetic field is applied. The laser power signal is modulated based on the pattern of bits. The modulation reduces differences between track widths of recorded marks having different elapsed time values and/or increases a signal-to-noise ratio of the recorded marks having different elapsed time values.

Abstract: Poly(acrylic acid)-based superabsorbent polymer (SAP) in a feed stream is converted into poly(acrylic acid) (PAA) in an extensional flow device. The total energy used to degrade the SAP into PAA is less than about 50 MJ/kg SAP.

Abstract: Poly(acrylic acid)-based superabsorbent polymer (SAP) in a feed stream is converted into poly(acrylic acid) (PAA) in an extensional flow device. The total energy used to degrade the SAP into PAA is less than about 50 MJ/kg SAP.

Abstract: Methods for detecting heterogeneity in data (e.g., flow cytometer data, nucleic acid sequence data) are provided. In some instances, methods include generating one or more population clusters based on the determined parameters of the analytes (e.g., cells, particles, nucleic acids) in a biological sample sample. In embodiments, methods include calculating a resolution index by computing a ratio between measures of variability and separation distance for any given number of pairs of first and second populations of data. Where desired, methods also include maximizing the resolution between populations of data by computing a resolution score that accounts for the sum of resolution indices, the number of populations, the number of parameters and the number of cells. Systems and computer-readable media for determining heterogeneity between populations of data and, where desired, maximizing resolution between populations of data, are also provided.

Abstract: Techniques for load balancing communication sessions in a networked computing environment are described herein. The techniques may include establishing a first communication session between a client device and a first computing resource of a networked computing environment. Additionally, the techniques may include storing, in a data store, data indicating that the first communication session is associated with the first computing resource. The techniques may further include receiving, at a second computing resource of the networked computing environment, traffic associated with a second communication session that was sent by the client device, and based at least in part on accessing the data stored in the data store, establishing a traffic redirect such that the traffic and additional traffic associated with the second communication session is sent from the second computing resource to the first computing resource.

Abstract: A personal care composition is disclosed comprising abrasive particles. The personal care composition may take a variety of forms such as a leave-on composition or an emulsion and/or may comprise one or more actives or agents.

Abstract: An apparatus includes an integrated circuit that includes a microprocessor and a microcontroller unit circuit (MCU) coupled to the microprocessor. The MCU includes a central processing unit (CPU) core and a network processor that implements a wireless interface. The MCU is configured to execute a location application that facilitates a determination of a physical location of the apparatus. The MCU may also be configured to support one or more management functions. The microprocessor sends data to the MCU for wireless transmission by the MCU's wireless interface.

Abstract: A nonwoven fabric. The nonwoven fabric can include a first surface and a second surface and a visually discernible pattern of three-dimensional features on one of the first or second surface. Each of the three-dimensional features can define a microzone comprising a first region and a second region. The first and second regions can have a difference in values for an intensive property, and wherein in at least one of the microzones the first region exhibits a Contact Angle of greater than 90 degrees, as measured by the Contact Angle Test Method detailed herein.

Abstract: Poly(acrylic acid)-based superabsorbent polymer (SAP) in a feed stream is converted with UV irradiation into poly(acrylic acid) (PAA) in a flow system. The UV total energy used to convert SAP into PAA is less than about 50 MJ/kg SAP.

Abstract: Anodizing of a shape memory material product or part includes polishing the shape memory material product or part, thereby producing a polished shape memory material product or part, and then anodizing the polished shape memory material product or part. The polishing of the shape memory material product or part includes mechanical polishing or electrochemical polishing. The electrochemical polishing includes placing the shape memory material product or part in an electrolyte and applying a voltage to the shape memory material product or part for a predetermined time. The anodizing of the polished shape memory material product or part includes placing the polished shape memory material product or part in an electrolyte and applying a voltage to the polished shape memory material product or part for a predetermined time period.

Abstract: Sachets composed of metal barrier layers that can include both a sealant and an external protective coating material. The sealant provides heat sealing, and product formulation protection properties, while the barrier material functions to reduce the moisture vapor transmission rate (MVTR) into or out of the sachet.

Abstract: Methods and architecture for load-correcting requests for serverless functions to reduce latency of serverless computing are provided. An example technique exploits knowledge that a given server node does not have a serverless function ready to run or is overloaded. Without further processing overhead or communication, the server node shifts the request to a predetermined alternate node without assessing a current state of the alternate node, an efficient decision based on probability that a higher chance of fulfillment exists at the alternate node than at the current server, even with no knowledge of the alternate node. In an implementation, the server node refers the request but also warms up the requested serverless function, due to likelihood of repeated requests or in case the request is directed back. An example device has a front-end redirecting server and a backend serverless system in a single component.

Abstract: A dental charting system and method of generating a dental chart are provided. The dental charting system comprises a display unit, an input unit and an output unit. The display unit is configured to display a quadrant view of a set of teeth. The quadrant view comprises a quadrant subset of the set of teeth, and at least one of a diagnosis field and a procedure field for each tooth in the quadrant subset. Each tooth in the quadrant subset displayed having a crown, a root and an outline. The input unit is configured to receive an input for at least one of the diagnosis field and the procedure field for at least one tooth in the quadrant set of teeth. The output unit is configured to generate a dental chart displaying the set of teeth. Each tooth in the set of teeth displayed in a color associated with the received input for at least one of the diagnosis field and the procedure field.

Abstract: This disclosure describes techniques and mechanisms for using a domain-specific language (DSL) to express and compile serverless network functions, and optimizing the deployment location for the serverless network functions on network devices. In some examples, the serverless network functions may be expressed entirely in the DSL (e.g., via a text-based editor, a graphics-based editor, etc.), where the DSL is a computer language specialized to a particular domain, such as a network function domain. In additional examples, the serverless network functions may be expressed and compiled using a DSL in combination with a general-purpose language (GSL). Once the serverless network function have been expressed and/or compiled, the techniques of this disclosure further include determining an optimized network component on which the serverless network function is to execute, and deploying the serverless function to the optimized network component.

Abstract: Routing packetized actions in a voice activated data packet based computer network environment is provided. A system can receive audio signals detected by a microphone of a device. The system can parse the audio signal to identify trigger keyword and request, and generate an action data structure. The action data structure can include digital components and entity-action pairs.

Abstract: A nonwoven fabric. The nonwoven fabric can include a first surface and a second surface and a visually discernible pattern of three-dimensional features on one of the first or second surface. Each of the three-dimensional features can define a microzone comprising a first region and a second region. The first and second regions can have a difference in values for an intensive property, and wherein in at least one of the microzones the first region exhibits a Contact Angle of greater than 90 degrees, as measured by the Contact Angle Test Method detailed herein.

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, PCSK9, or a pharmaceutically acceptable salt, solvate, prodrug or polymorph thereof, and to compositions and formulations comprising such compounds, and methods of using and making such compounds. Compounds include comprising of Formula (I): (I) wherein A, D and Q are described herein.

Abstract: An apparatus includes an integrated circuit that includes a microprocessor and a microcontroller unit circuit (MCU) coupled to the microprocessor. The MCU includes a central processing unit (CPU) core and a network processor that implements a wireless interface. The MCU is configured to execute a location application that facilitates a determination of a physical location of the apparatus. The MCU may also be configured to support one or more management functions. The microprocessor sends data to the MCU for wireless transmission by the MCU's wireless interface.