Abstract: A surface cleaning apparatus including a body defining an agitation chamber, an agitator partially disposed within the agitation chamber and configured to rotate about a pivot axis, and a debrider at least partially disposed within the agitation chamber. The agitator includes an elongated body having a first and a second end, a sidewall extending radially outward from the elongated body extending between the first and the second ends, and a plurality of bristles extending radially outward from the elongated body. The plurality of bristles are arranged in at least one row adjacent to the sidewall. The debrider includes a plurality of teeth configured to contact a portion of the sidewall as the agitator rotates about the pivot axis.

Abstract: Disclosed are cyclopropanated carbohydrate compounds of formulas I and II: Also disclosed are methods of treating or preventing a central nervous system ailment by administering to an organism in need thereof an effective amount of a cyclopropanated carbohydrate compound of formula I or II and pharmaceutical compositions containing a cyclopropanated carbohydrate compound of formula I or II.

Abstract: A serrated cutting strip (22) for a roll of clingfilm (20), foil or the like is made of compostable material such as polylactic acid.

Abstract: This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.

Abstract: Disclosed are cyclopropanated carbohydrate compounds of formulas I and II: Also disclosed are methods of treating or preventing a central nervous system ailment by administering to an organism in need thereof an effective amount of a cyclopropanated carbohydrate compound of formula I or II and pharmaceutical compositions containing a cyclopropanated carbohydrate compound of formula I or II.

Abstract: This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.

Abstract: The present invention provides a cutting strip (102) which includes a flat, strip member (201) adapted to be attached to the edge of a carton. The member (201) having a first edge (202) having a plurality of teeth (204). The plurality of teeth (204) having a non-uniform tooth pattern (205) which comprises a first tooth pattern along a first section (209) of the edge and a second tooth pattern (207) along a second section (210) of the edge so that a sheet-tearing force can be applied to a sheet on either the first end or the second end of the member (201).

Abstract: This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.

Abstract: This invention provides an apparatus for attaching a cutting strip to a carton blank. The apparatus includes a first member for conveying carton blanks past a second member, and the second member is arranged to cut a cuffing strip from a supply of cuffing strip material and deposit the cutting strip upon a carton blank. The first member may be a conveyor belt fitted with a suction member, and the second member may be upper and lower dies that are movable relative to one another and a member that can feed a supply of cutting strip material between the dies. Initial downward movement of the upper die cuts a cutting strip from the supply of cutting strip material and the cutting strip is retained on the upper die. Further downward movement of the upper die brings the cutting strip into contact with a carton blank. The apparatus may also include an alignment member to ensure that the carton blanks are properly positioned relative to the second member when the cutting strips are attached.

Abstract: This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.

Abstract: There is provided apparatus (10) for attaching a serrated cutting strip to a carton blank comprising a first means for (24) conveying carton blanks past a second means (16), the second means (16) being arranged to cut a cutting strip from a supply (38) of cutting strip material and deposit said cutting strip upon a carton blank. The first means comprises a conveyor belt (24) preferably fitted with suction means, and the second means (16) comprises upper (58) and lower dies movable relative to one another and means (14) to feed a supply of cutting strip material between said dies. In use initial downward movement of the upper die (58) cuts a cutting strip from the supply of cutting strip material, said cutting strip being retained upon the upper die (58) by suction. Further downward movement of the upper die (58) brings the cutting strip into contact with a carton blank.

Abstract: An apparatus for attaching a serrated cutting strip to a carton blank which includes a first member for conveying carton blanks past a cutting and applicator mechanism, the cutting and applicator mechanism being arranged to cut a cutting strip from a supply of cutting strip material and deposit said cutting strip upon a carton blank. The first member includes a conveyor belt preferably fitted with suction means, and the cutting and applicator mechanism includes upper and lower dies movable relative to one another and a mechanism to feed a supply of cutting strip material, said cutting strip being retained upon the upper die by suction. Further downward movement of the upper die brings the cutting strip into contact with a carton blank. The apparatus includes an alignment member to ensure the carton blanks are correctly positioned relative to the cutting and applicator mechanism when the cutting strips are attached.

Abstract: A serrated cutting strip (26) for a carton comprises paper or board impregnated with a mix of acrylic resin and urea formaldehyde. The strip is 0.2 to 0.5 mm in thickness and can bend without cracking over a bar of 20 mm diameter. The strip has adhesive on one side and a release sheet (28) on the adhesive. The strip is applied to a carton by apparatus (10) which comprises rollers (44,45) for advancing a substrate sheet (24), a cutter (12) and means (44,45) for drawing a release sheet (28) away from the edge (46).