Abstract: The present invention provides a method of treating a solid tumour in a subject, the method comprising the following steps (i) delivering to the solid tumour a composition comprising an engineered ovine atadenovirus; and (ii) administering a prodrug to the subject, wherein the engineered ovine atadenovirus comprises a promoter and a gene encoding an enzyme which converts the prodrug to a cytotoxic metabolite, the gene being under control of the promoter.

Abstract: Various heat cycles are disclosed which make use of comparatively low grade heat such as that from hot rock geo-thermal sources, the cycles incorporating either a helical screw expander or a rotary vane expander operating with an organic working fluid and in accordance with the invention, the exhaust from the helical screw expander or rotary vane expander is used in a conventional rankine cycle.

Abstract: A method of converting thermal energy into another energy form, comprising the steps of providing a liquid working fluid with said thermal energy, substantially adiabatically compressing the working fluid, substantially adiabatically expanding the hot compressed working fluid by flashing to yield said other energy form in an expansion machine capable of operating with wet working fluid and of progressively drying said fluid during expansion, and condensing the exhaust working fluid from the expansion machine. Apparatus for converting thermal energy into another energy form is also provided.