Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, X, Y and A have the meanings given herein which are useful in the curative and prophylactic treatment of a medical condition for which inhibition of a cyclic guanosine 3′,5′-monophosphate phosphodiesterase (e.g. cGMP PDE5) is desired.

Abstract: Compounds of general formula I: or pharmaceutically or veterinarily acceptable salts, solvates, polymorphs or pro-drugs thereof wherein: wherein R1, R2, R3, R4, X and A have the meanings given herein which are useful in the curative and prophylactic treatment of a medical condition for which inhibition of a cyclic guanosine 3′,5′-monophosphate phosphodiesterase (e.g. cGMP PDE5) is desired.

Abstract: Compound of general formula I: wherein R1, R2, R3, R4, X, Y and R5 have the meanings given herein which are useful in the curative and prophylactic treatment of a medical condition for which inhibition of a cyclic guanosine 3′,5′-monophosphate phosphodiesterase (e.g. cGMP PDE5) is desired.

Abstract: A submersible article comprises a buoyancy body formed from polyurethane foam having a first density, which is at least partly overmolded with a protective skin of polyurethane foam having a second density higher than the first density. The lower density foam of the body gives the article buoyancy, while the higher density protective skin strengthens the article and gives impact resistance. The protective skin can be stiffened, either uniformly or locally, by the addition of glass fiber or other reinforcing material which is arranged over the buoyancy body prior to the overmolding. The article can be made by a two-stage molding process.

Abstract: The invention relates to PDE9 inhibitors for treating cardiovascular disorders. Preferred PDE9 inhibitors are compounds of formula I wherein R1 is H or C1-6 alkyl, wherein R1 is attached to either N1 or N2; R2 is C1-6 alkyl optionally substituted by hydroxy or alkoxy; C3-7 cycloalkyl optionally substituted by alkyl, hydroxy or alkoxy; a saturated 5-6-membered heterocycle optionally substituted by alkyl, hydroxy or alkoxy; het1 or Ar1; R3 is C1-6 alkyl optionally substituted by 1 or 2 groups independently selected from: Ar2; C3-7cycloalkyl optionally substituted by C1-6alkyl; OAr2; SAr2; NHC(O)C1-6 alkyl; het2; xanthene; and naphthalene.

Abstract: A submersible article comprises a buoyancy body formed from polyurethane foam having a first density, which is at least partly overmolded with a protective skin of polyurethane foam having a second density higher than the first density. The lower density foam of the body gives the article buoyancy, while the higher density protective skin strengthens the article and gives impact resistance. The protective skin can be stiffened, either uniformly or locally, by the addition of glass fiber or other reinforcing material which is arranged over the buoyancy body prior to the overmolding. The article can be made by a two-stage molding process.

Abstract: Compounds of the formula (I): wherein A, Y, R, X, R1, R2, R3 and R4 are as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases or other disorders involving nerve damage.

Abstract: Compound of general formula I: 1

Abstract: Compounds of general formula I: 1

Abstract: Compounds of general formula (I): 1

Abstract: Compounds of the formula (I): wherein A, Y, R, X, R1, R2, R3 and R4 are as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases or other disorders involving nerve damage.

Abstract: A one piece wheel rim for a pneumatic tire having flanges adjacent to tapered bead seats one of the flanges having a reduced high portion of a length of 0.25 to 0.5 times the bead seat circumference. The reduced height portion being in the range of 0.15 to 0.6 times the height of the remainder of the flange, which construction allows a tire to be fitted to the rim without the necessity for a conventional tire fitting well.

Abstract: A novel one piece wheel rim for a pneumatic tire is provided. This wheel rim includes a pair of axially spaced tapered bead seats, a tire retaining flange located axially outward of each bead seat, and a tire fitting well located between the bead seats. One flange has a reduced height portion having a length of 0.25 to 0.5 times the bead seat circumference. The reduced height is such that the flange height, measured from its heel point, which is the point of intersection of the nominal diameter and the nominal wheel width, is in the range of 0.15 and 0.6 times the height of the remainder of the tire. This construction permits easy tire fitting and removal. The well also provides increased brake space.

Abstract: A tire tread for a truck tire, especially of radial ply construction and designed for use on well-made roads, comprising a small number of zig-zag grooves. The sidewalls of each groove are each provided with a supporting buttress of varying height or width such that the maximum support is provided at or adjacent the points where the groove projects into the surrounding tread rubber. The provision of such a buttress provides a varying degree of support for each groove sidewall along the length of the groove and assists in preventing uneven wear of the tread rubber and reduces damage caused by stones trapped in the groove.

Abstract: A tire and wheel rim assembly having improved bead retention characteristics when run deflated.One or both bead seats is substantially straight and provided with an abutment respectively which is substantially continuous in the circumferential direction. Each abutment has a maximum radial dimension less than the minimum diameter of the tire bead reinforcement to allow fitment of the tire to a one-piece rim having a tire fitting well by conventional techniques. The taper of the bead seats is selected to enable abutments to be provided which have sufficient radial dimension or height relative to the adjacent bead seat such that under the action of road generated forces rotation of the tire beads about the adjacent abutment is effected to retain the tire beads at the bead seats.

Abstract: A pneumatic tire and wheel rim assembly is disclosed in which the rim bead seats are defined by grooves having radially directed side portions which retain the associated tire bead against movement in an axial direction and each rim bead seat includes means in engagement with the tire bead to restrict rotation of the tire bead relative to the bead seat. Preferably said means comprises a plurality of projections formed integrally with part or all of the grooves which engage the associated tire bead to restrict rotation. Each projection may comprise a circumferentially extending rib or a tooth.