Abstract: Provided are compounds capable of enhancing the ability of receptor-type tyrosine-protein phosphatase delta (PTPRD) to dephosphorylate a kinase. Also disclosed is a method of treating a tauopathy or restless leg syndrome in a subject comprising administering to the subject an effective amount of a disclosed compound. Also disclosed are kits comprising the compounds together with instructions for treating a condition and/or a compound known for treating the condition. Finally, disclosed herein is a screening method suitable for identifying positive allosteric modulators of the ability of a receptor-type tyrosine-protein phosphatase delta (PTPRD) to dephosphorylate a kinase.

Abstract: Disclosed are small molecule PTPRD inhibitors and uses thereof. Methods of using the PTPRD inhibitors include methods of treating, preventing, or delaying the progression of a disorder responsive to PTPRD inhibition, including for example nicotine dependence, addiction, obesity, metabolic syndrome, and substance-use disorders such as stimulant-use disorders and opioid-use disorders.

Abstract: Provided are compounds capable of enhancing the ability of receptor-type tyrosine-protein phosphatase delta (PTPRD) to dephosphorylate a kinase. Also disclosed is a method of treating a tauopathy or restless leg syndrome in a subject comprising administering to the subject an effective amount of a disclosed compound. Also disclosed are kits comprising the compounds together with instructions for treating a condition and/or a compound known for treating the condition. Finally, disclosed herein is a screening method suitable for identifying positive allosteric modulators of the ability of a receptor-type tyrosine-protein phosphatase delta (PTPRD) to dephosphorylate a kinase.

Abstract: Stacked tab views are described. A computing device can display multiple content panes in a web browser window. Each content pane can correspond to a different web site. The content panes can be arranged in a visual stack, where content pane are positioned one in front of another in a three-dimensional view. In the three-dimensional view, a distance between content panes can appear to separate the content panes. Each content pane can display snapshot image of content of a web site. The content panes can be used in place of tabs for navigating between web pages.

Abstract: Stacked tab views are described. A computing device can display multiple content panes in a web browser window. Each content pane can correspond to a different web site. The content panes can be arranged in a visual stack, where content pane are positioned one in front of another in a three-dimensional view. In the three-dimensional view, a distance between content panes can appear to separate the content panes. Each content pane can display snapshot image of content of a web site. The content panes can be used in place of tabs for navigating between web pages.

Abstract: Stacked tab views are described. A computing device can display multiple content panes in a web browser window. Each content pane can correspond to a different web site. The content panes can be arranged in a visual stack, where content pane are positioned one in front of another in a three-dimensional view. In the three-dimensional view, a distance between content panes can appear to separate the content panes. Each content pane can display snapshot image of content of a web site. The content panes can be used in place of tabs for navigating between web pages.

Abstract: Stacked tab views are described. A computing device can display multiple content panes in a web browser window. Each content pane can correspond to a different web site. The content panes can be arranged in a visual stack, where content pane are positioned one in front of another in a three-dimensional view. In the three-dimensional view, a distance between content panes can appear to separate the content panes. Each content pane can display snapshot image of content of a web site. The content panes can be used in place of tabs for navigating between web pages.

Abstract: Stacked tab views are described. A computing device can display multiple content panes in a web browser window. Each content pane can correspond to a different web site. The content panes can be arranged in a visual stack, where content pane are positioned one in front of another in a three-dimensional view. In the three-dimensional view, a distance between content panes can appear to separate the content panes. Each content pane can display snapshot image of content of a web site. The content panes can be used in place of tabs for navigating between web pages.