Publication number: 20240094233
Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.
Type:
Application
Filed:
July 18, 2023
Publication date:
March 21, 2024
Inventors:
Jacob N. WOHLSTADTER, Manish KOCHAR, Peter J. BOSCO, Ian D. CHAMBERLIN, Bandele JEFFREY-COKER, Eric M. JONES, Gary I. KRIVOY, Don E. KRUEGER, Aaron H. LEIMKUEHLER, Pei-Ming WU, Kim-Xuan NGUYEN, Pankaj OBEROI, Louis W. PANG, Jennifer PARKER, Victor PELLICIER, Nicholas SAMMONS, George SIGAL, Michael L. VOCK, Stanley T. SMITH, Carl C. STEVENS, Rodger D. OSBORNE, Kenneth E. PAGE, Michael T. WADE, Jon WILLOUGHBY, Lei WANG, Xinri CONG, Kin NG
Publication number: 20120142546
Abstract: The present invention provides methods and kits for identifying a cell that exhibits or is predisposed to exhibiting unregulated growth by detecting hypomethylation of a gene or a regulatory region in at least one gene in the cell. Also provided are methods for diagnosis or prognosis of a proliferative disorder in a subject. Also provided are methods of ameliorating a cell proliferative disorder in a subject by administering to the subject an agent that methylates a hypomethylated gene or regulatory region thereof. In some aspects, the gene or regulatory region thereof is TKTL1, H19, MAGEA2, MAGEA3, MAGEA4, MAGEA11, GPR1 7, GRTN1, C19ORF28, MAGEA12, MAGEA1, MAGEA5, NY-ESO-1, MAGEA9, MAGEA6, MAGEB2, CT45-2, SBSN, G6PD, ZNF711, CrispL, KRT86, KIPV467, KRT81, CSPG5, PP1R14A, KISS1R, KIAA1937 protein, SOX30, DEAD, or KBGP.
Type:
Application
Filed:
December 10, 2008
Publication date:
June 7, 2012
Applicant:
THE JOHNS HOPKINS UNIVERSITY
Inventors:
Joseph A. Califano, Ian M. Smith