Abstract: A bonnet and stuffing box assembly includes a bonnet defining a bonnet bore; a stuffing box connected to the bonnet, the stuffing box defining a stuffing box bore, the stuffing box bore and bonnet bore defining an assembly bore; a bushing assembly received in the assembly bore and comprising a stuffing box bushing and a bonnet bushing, the stuffing box bushing defining a narrow portion disposed in the stuffing box bore and a wide portion at least partially disposed in the bonnet bore, the bonnet bushing disposed in the bonnet bore and confronting the wide portion of the stuffing box bushing, the bushing assembly defining a bushing bore extending through the stuffing box bushing and the bonnet bushing; and a stem extending through the bushing bore.

Abstract: Methods of lowering LDL cholesterol in a pediatric subject having a cholesterol-related disorder, e.g., heterozygous familial hypercholesterolemia (HeFH), by administering a PCSK9 inhibitor are provided.

Abstract: Example aspects of a method of using a bonnet and stuffing box assembly and a method of manufacturing a bonnet and stuffing box assembly are disclosed. The method of using a bonnet and stuffing box assembly can comprise providing a stuffing box, a bonnet, a bushing assembly, and a stem, the stuffing box and the bonnet defining an assembly bore, the bushing assembly received in the assembly bore, the bushing assembly defining a bushing bore, and the stem received through the bushing bore; sealing the stem relative to the bushing assembly to prohibit fluid flow through the bushing bore; sealing the bushing assembly relative to the bonnet to prohibit fluid flow through the assembly bore; and turning the stem relative to the bushing assembly, bonnet, and stuffing box to actuate a valve.

Abstract: Devices, systems, and methods of the present disclosure can overcome physical constraints associated with catheter introduction to facilitate the use of a catheter with a large distal portion as part of a medical procedure benefitting from such a large distal portion, such as, for example, cardiac ablation. More specifically, devices, systems, and methods of the present disclosure can compress an expandable tip of a catheter from an expanded state to a compressed state along a tapered surface of an insertion sleeve for advancement of the expandable tip into vasculature of a patient. The tapered surface of the insertion sleeve can, for example, apply compressive forces at an angle against the advancing expandable tip. As compared to other approaches to the application of compressive force to an expandable tip, compressing the expandable tip using an angled force can reduce the likelihood of unintended deformation of the expandable tip.

Abstract: Methods for patterning of multi-depth layers for the fabrication of optical devices are provided. In one embodiment, a method is provided that includes disposing a resist layer over a device layer disposed over a top surface of a substrate, the device layer having a first portion and a second portion, patterning the resist layer to form a first resist layer pattern having a plurality of first openings and a second resist layer pattern having a plurality of second openings, and etching exposed portions of the device layer defined by the plurality of first openings and the plurality of second openings, wherein the plurality of first openings are configured to form at least a portion of a plurality of first structures within the optical device, and the plurality of second openings are configured to form at least a portion of a plurality of second structures within the optical device.

Abstract: A flexible light emitting substrate in accordance with an embodiment hereof includes a controller, a base substrate that carries a data source printed or displayed thereon, which defines a plurality of grid locations, and a data display source provided on, under, or within the base substrate and is wirelessly or wiredly coupled to the controller. Each data display source is associated with a respective grid coordinate or with a specific location or with a position of an object or person relative to a boundary displayed on the base substrate. The embodiment further includes a position sensor for determining the current location of a person or object, and a power source for providing power to the data display source and the controller, where the controller is configured for selectively controlling operation of the data display source based at least partially on the determined current location of the person or object.

Abstract: A game controller includes a touchpad that a user, viewing a virtual keyboard on a screen, can soft-touch to move a cursor on the screen and then hard-touch to move the cursor and also send location data to a processor for inputting a letter from the virtual keyboard. Machine learning is used to predict a next letter or next word.

Abstract: Systems and methods for alternative payment mechanism payments using ultra-wideband radio technology are disclosed. A method may include a payment terminal computer program executed by a payment terminal selecting a customer electronic device that is conducting the payment transaction with the payment terminal; communicating, via a payment terminal UWB radio to the selected customer electronic device, payment transaction details for the payment transaction comprising a merchant identifier and a transaction amount; receiving, from the selected customer electronic device via the payment terminal UWB radio, an APM payment message for an APM payment provider; communicating the APM payment message to the APM payment provider, wherein the APM payment provider is configured to decision the transaction based on the APM payment message; and receiving, from the APM payment provider, a payment confirmation for the payment transaction.

Abstract: A method for electronic receipt transfer via ultra-wideband electronic (UWB) radio technology may include: causing, by a payment terminal computer program, an UWB radio to transmit a range request signal from a first antenna; receiving, by the payment terminal computer program and one or more customer electronic devices, a pair of replies to the range request signal, each comprising a first reply signal received at the first antenna and a second reply signal received at a second antenna; determining, by the payment terminal computer program, a distance between the UWB radio and each customer electronic device based on a time of flight; selecting, by the payment terminal computer program, the customer electronic devices having the distance that is closest to the UWB radio; and communicating, by the payment terminal computer program, an electronic receipt for a transaction to the selected customer electronic device.

Abstract: Devices, systems, and methods of the present disclosure can overcome physical constraints associated with catheter introduction to facilitate the use of a catheter with a large distal portion as part of a medical procedure benefiting from such a large distal portion, such as, for example, cardiac ablation. More specifically, devices, systems, and methods of the present disclosure can compress an expandable tip of a catheter from an expanded state to a compressed state along a tapered surface of an insertion sleeve for advancement of the expandable tip into vasculature of a patient. The tapered surface of the insertion sleeve can, for example, apply compressive forces at an angle against the advancing expandable tip. As compared to other approaches to the application of compressive force to an expandable tip, compressing the expandable tip using an angled force can reduce the likelihood of unintended deformation of the expandable tip.

Abstract: A combination recreation vehicle and houseboat having an upper enclosure assembly and a lower floating chassis assembly with a floor system portion, wherein the upper and lower assemblies are movable between a retracted condition and an extended condition independently of each other.

Abstract: A method for managing a wireless communication between an implantable medical device and at least two external devices includes associating the implantable medical device with a first external device so as to enable communication between the first external device and the implantable medical device via a wireless connection, and activating a search mode of the implantable medical device. In the search mode, the implantable medical device wirelessly sends out an advertising message that indicates its availability for association with at least a second external device. A blocking mode of the first external device is activated in response to the activation of the search mode of the implantable medical device. In the blocking mode, the first external device is disconnected from the implantable medical device and does not attempt to connect with the implantable medical device.

Abstract: A network based media distribution platform includes a server connected to the network, the server including at least one data repository, and a non-transitory medium with a set of machine readable instructions executable therefrom coupled to the server, the instructions causing the server to (a) receive media content from a creator using a media capture device or system to create and upload content, (b) buffer the content for distribution over the network to one or more creator channels accessible to consumers operating media playback devices or systems connected to consumer platform, (c) authenticate the media content to the content creator using at least token data, (d) register the media content and creator authentication data on a connected blockchain storing information in distributed ledger form, and (e) distribute the content to creator channel(s) accessible to the consumers operating the network-connected playback devices or systems connected to the consumer platforms.

Abstract: Data is obtained from a data stream managed by a data stream service prior to expiration of a data retention time. The data is archived to a data store distinct from the data stream service (e.g., in a full or compacted mode). Access to the archived data is provided via a proxy that intercepts requests directed to the streaming service. For example, the proxy or a redirect utility for the proxy may intercept a query, and for data specified in the query that is past the retention expiration time, the data is retrieved from the data store. For data specified in the query that has not yet expired, the data is retrieved from the data stream service. In either case, the system responds to the query with the retrieved data according to the access interface of the data stream service (e.g., injecting the retrieved data into a data stream).

Abstract: Methods for patterning of multi-depth layers for the fabrication of optical devices are provided. In one embodiment, a method is provided that includes disposing a resist layer over a device layer disposed over a top surface of a substrate, the device layer having a first portion and a second portion, patterning the resist layer to form a first resist layer pattern having a plurality of first openings and a second resist layer pattern having a plurality of second openings, and etching exposed portions of the device layer defined by the plurality of first openings and the plurality of second openings, wherein the plurality of first openings are configured to form at least a portion of a plurality of first structures within the optical device, and the plurality of second openings are configured to form at least a portion of a plurality of second structures within the optical device.

Abstract: Embodiments of the present invention are directed to managing process analytics across process components. In some embodiments, an indication of a state of a process instance associated with a process is determined by querying a process engine. In accordance with the indication of the state of the process instance, an augmented process model is used to search machine data for data corresponding with at least one component of the process. The data corresponding with the at least one component of the process is associated with a process instance identifier that uniquely identifies the process instance. Thereafter, the data along with the process instance identifier is provided to the process engine to update the state of the process instance.