Abstract: Partially degradable stents formed of electrospun polymeric fibers have been developed. The lumen of the stent enlarges as the degradable polymeric inner luminal wall of the stents degrades over. When inserted in the eye of a subject connecting anterior chamber to the subconjunctival space, the stents allows for controlled outflow of aqueous humor, providing controlled of the rate of change in the intraocular pressure (TOP) and sustained decrease of TOP to treat eye disorders such as glaucoma. Methods of making these fibers via electrospinning and heat processing, as well as their uses in medical applications, are also provided.

Abstract: Controlled release microparticular formulations for the delivery of active agents, especially for treatment of eye diseases or disorders, such as glaucoma, have been developed. These provide release of the active agent, such as a hydrophilic carbonic anhydride inhibitor, for an effective period of time such as a least one month after injection into the eye for treatment of glaucoma.