Patents by Inventor Ian Pitha

Ian Pitha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PARTIALLY DEGRADABLE STENTS FOR CONTROLLED REDUCTION OF INTRAOCULAR PRESSURE
    Publication number: 20190046696
    Abstract: Partially degradable stents formed of electrospun polymeric fibers have been developed. The lumen of the stent enlarges as the degradable polymeric inner luminal wall of the stents degrades over. When inserted in the eye of a subject connecting anterior chamber to the subconjunctival space, the stents allows for controlled outflow of aqueous humor, providing controlled of the rate of change in the intraocular pressure (TOP) and sustained decrease of TOP to treat eye disorders such as glaucoma. Methods of making these fibers via electrospinning and heat processing, as well as their uses in medical applications, are also provided.
    Type: Application
    Filed: March 13, 2017
    Publication date: February 14, 2019
    Inventors: Kunal S. Parikh, Ian Pitha, Justin Hanes
  • COMPOSITIONS FOR SUSTAINED RELEASE OF ANTI-GLAUCOMA AGENTS TO CONTROL INTRAOCULAR PRESSURE
    Publication number: 20190022016
    Abstract: Controlled release microparticular formulations for the delivery of active agents, especially for treatment of eye diseases or disorders, such as glaucoma, have been developed. These provide release of the active agent, such as a hydrophilic carbonic anhydride inhibitor, for an effective period of time such as a least one month after injection into the eye for treatment of glaucoma.
    Type: Application
    Filed: March 2, 2017
    Publication date: January 24, 2019
    Inventors: Jie Fu, Ian Pitha, Harry Quigley, Justin Hanes
  • Compositions and methods for preventing and treating cancer via modulating UBE1L, ISG215 and/or UBP43
    Patent number: 8697668
    Abstract: Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.
    Type: Grant
    Filed: September 17, 2012
    Date of Patent: April 15, 2014
    Assignee: Trustees of Dartmouth College
    Inventors: Ethan Dmitrovsky, Bret C. Hassel, Sutisak Kitareewan, Ian Pitha-Rowe
  • Compositions and Methods for Preventing and Treating Cancer via Modulating UBE1L, ISG215 and/or UBP43
    Publication number: 20130041016
    Abstract: Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.
    Type: Application
    Filed: September 17, 2012
    Publication date: February 14, 2013
    Applicant: Trustees of Dartmouth College
    Inventors: Ethan Dmitrovsky, Bret C. Hassel, Sutisak Kitareewan, Ian Pitha-Rowe
  • Compositions and methods for preventing and treating cancer via modulating UBE1L, ISG15 and/or UBP43
    Patent number: 8283113
    Abstract: Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: October 9, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Ethan Dmitrovsky, Bret A. Hassel, Sutisak Kitareewan, Ian Pitha-Rowe
  • Compositions and methods for preventing and treating cancer via modulating UBE1L, ISG15 and/or UBP43
    Publication number: 20090131357
    Abstract: Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.
    Type: Application
    Filed: October 31, 2008
    Publication date: May 21, 2009
    Inventors: Ethan Dmitrovsky, Bret A. Hassel, Sutisak Kitareewan, Ian Pitha-Rowe
  • Compositions and methods for preventing and treating cancer via modulating ube1l, isg15 and/or ubp43
    Publication number: 20050148502
    Abstract: Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15 or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.
    Type: Application
    Filed: March 5, 2003
    Publication date: July 7, 2005
    Inventors: Ethan Dmitrovsky, Bret Hassel, Sutisak Kitareewan, Ian Pitha-Rowe