Patents by Inventor Ian Quigley
Ian Quigley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240109111Abstract: A method for use by a system coupled to at least one sensor and at least one flow control mechanism of a gas extraction system, the system comprising at least one controller and configured for use in connection with a landfill gas extraction process for extraction of landfill gas from a landfill via the gas extraction system, the method comprising: using the at least one controller to perform: obtaining, based on at least one measurement made by the at least one sensor, at least one current value indicative of a selected characteristic of the landfill gas extraction process, determining, at discrete time intervals, whether the at least one current value satisfies at least one compliance criterion for the selected characteristic, and when it is determined that the at least one current value does not satisfy the at least one compliance criterion for the selected characteristic, performing a corrective action.Type: ApplicationFiled: December 14, 2023Publication date: April 4, 2024Applicant: Loci Controls, Inc.Inventors: Peter Quigley, Ian Martin, Jack Rowbottom, Nicole Neff
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Publication number: 20240109110Abstract: A control system for controlling extraction of landfill gas from a landfill via a gas extraction system comprising well piping, the landfill gas having a first temperature when extracted, the control system comprising: a gas composition chamber coupled to the well piping and comprising at least one sensor configured to measure one or more characteristics of a landfill gas sample in the gas composition chamber; a temperature control mechanism configured to heat the landfill gas sample in the gas composition chamber to a second temperature at least a threshold amount greater than the first temperature; and a controller configured to control the at least one sensor to measure the one or more characteristics of the landfill gas sample in the gas composition chamber when a temperature of the landfill gas sample in the gas composition chamber is at least the threshold amount greater than the first temperature.Type: ApplicationFiled: December 1, 2023Publication date: April 4, 2024Applicant: Loci Controls, Inc.Inventors: Peter Quigley, Ian Martin, Joseph G. Michels, Melinda Sims
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Publication number: 20240091831Abstract: Systems and methods for controlling extraction of landfill gas from a landfill via a gas extraction system comprising a plurality of wells are provided herein. In some embodiments, the method comprises obtaining a concentration of a greenhouse gas measured a distance above a surface of a region comprising the plurality of wells; determining whether the measure of the concentration of the greenhouse gas is greater than a first threshold; and in response to determining that the measure of the concentration of the greenhouse gas is greater than the first threshold, increasing a flow rate of landfill gas being extracted from at least one well of the plurality of wells.Type: ApplicationFiled: November 22, 2023Publication date: March 21, 2024Applicant: Loci Controls, Inc.Inventors: Peter Quigley, Ian Martin, Nicole Neff, Jack Rowbottom
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Publication number: 20240066573Abstract: A control system for controlling extraction of landfill gas, comprising: at least one sensor configured to measure one or more characteristics of landfill gas; at least one flow control mechanism disposed in well piping and configured to control flow of the landfill gas through the well piping; and at least one processor configured to: obtain a measured concentration of a first gas in landfill gas; determine whether the measured concentration of the first gas is either less than a first threshold concentration or greater than a second threshold concentration; when it is determined that the measured concentration is less than the first threshold concentration, control the at least one flow control mechanism to reduce flow rate of landfill gas; and when it is determined that the concentration is greater than the second threshold concentration, control the at least one flow control mechanism to increase the flow rate of landfill gas.Type: ApplicationFiled: October 31, 2023Publication date: February 29, 2024Applicant: Loci Controls, Inc.Inventors: Andrew Campanella, Joseph G. Michels, Peter Quigley, Ian Martin
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Publication number: 20240066572Abstract: A control system for controlling extraction of landfill gas, comprising: at least one sensor configured to measure one or more characteristics of landfill gas; at least one flow control mechanism disposed in well piping and configured to control flow of the landfill gas through the well piping; and at least one processor configured to: obtain a measured concentration of a first gas in landfill gas; determine whether the measured concentration of the first gas is either less than a first threshold concentration or greater than a second threshold concentration; when it is determined that the measured concentration is less than the first threshold concentration, control the at least one flow control mechanism to reduce flow rate of landfill gas; and when it is determined that the concentration is greater than the second threshold concentration, control the at least one flow control mechanism to increase the flow rate of landfill gas.Type: ApplicationFiled: October 31, 2023Publication date: February 29, 2024Applicant: Loci Controls, Inc.Inventors: Andrew Campanella, Joseph G. Michels, Peter Quigley, Ian Martin
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Publication number: 20240029832Abstract: In a system for identifying a subset of compounds in a plurality of compounds, the identifying includes obtaining via high throughput screening, for each compound, a vector including a set of elements. Each element includes a measurement of a different feature of an instance of a cell context upon exposure to the compound. The obtaining is repeated for a plurality of cell contexts to obtain a plurality of vectors for each compound across different cell contexts. The vectors are combined for each compound to form a combined vector for each compound, thereby forming a plurality of combined vectors representing different compounds. The plurality of compounds is pruned to the subset of compounds based on a similarity between respective combined vectors in the plurality of combined vectors corresponding to compounds in the plurality of compounds. The subset is used as a reduced size smart compound library to perform pharmaceutical drug discovery.Type: ApplicationFiled: October 3, 2023Publication date: January 25, 2024Applicant: Recursion Pharmaceuticals, Inc.Inventors: Chris GIBSON, Blake C. BORGESON, Mason L. VICTORS, David HEALEY, Ian QUIGLEY, Ronald Wakim ALFA
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Patent number: 11791019Abstract: The disclosure provides methods and systems for identifying a subset of compounds in a plurality of compounds. The identifying includes obtaining, for each compound, a vector including a set of elements, where each element includes a measurement of a different feature of an instance of a cell context upon exposure to the compound. The identifying includes repeating the obtaining for a plurality of cell contexts, to obtain a plurality of vectors for each compound across different cell contexts. The identifying includes combining the vectors for each compound to form a combined vector for each compound, thereby forming a plurality of combined vectors representing different compounds. The identifying includes pruning the plurality of compounds to the subset of compounds based on a similarity between respective combined vectors in the plurality of combined vectors corresponding to compounds in the plurality of compounds.Type: GrantFiled: July 18, 2022Date of Patent: October 17, 2023Assignee: Recursion Pharmaceuticals, Inc.Inventors: Chris Gibson, Blake C. Borgeson, Mason L. Victors, David Healey, Ian Quigley, Ronald Wakim Alfa
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Publication number: 20220406414Abstract: The disclosure provides methods and systems for identifying a subset of compounds in a plurality of compounds. The identifying includes obtaining, for each compound, a vector including a set of elements, where each element includes a measurement of a different feature of an instance of a cell context upon exposure to the compound. The identifying includes repeating the obtaining for a plurality of cell contexts, to obtain a plurality of vectors for each compound across different cell contexts. The identifying includes combining the vectors for each compound to form a combined vector for each compound, thereby forming a plurality of combined vectors representing different compounds. The identifying includes pruning the plurality of compounds to the subset of compounds based on a similarity between respective combined vectors in the plurality of combined vectors corresponding to compounds in the plurality of compounds.Type: ApplicationFiled: July 18, 2022Publication date: December 22, 2022Applicant: Recursion Pharmaceuticals, Inc.Inventors: Chris GIBSON, Blake C. Borgeson, Mason L. Victors, David Healey, Ian Quigley, Ronald Wakim Alfa
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Publication number: 20220397565Abstract: Disclosed herein are methods of high-throughput screening test agents for treating a disease. Also disclosed herein are methods of high-throughput screening diseases. Systems for high-throughput screening are also disclosed herein.Type: ApplicationFiled: June 10, 2021Publication date: December 15, 2022Inventors: Chris Johnson, Ian Quigley, Renat Khaliullin, Timothy Dahlem, Daniel Anderson
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Publication number: 20220238181Abstract: A system for selecting CRISPR guides for knocking out one or more target genes in a target cell from a multiplicity of candidate guides comprises a memory and a processor. The processor determines whether the candidate guide meets a plurality of thresholds. The thresholds are associated with: a transcript support level; targeting a consensus sequence of a target gene; which exon of the target gene is targeted; targeting of a primary transcript, targeting of a common isoform; a precomputed prediction of editing outcomes; mapping to an expressed sequence; fraction of gene expression attributable to targeted transcripts; a common SNP overlap threshold; which exon of the target gene is targeted; overlap of a selected guide; predicted frameshift percentage; maximum and minimum GC content; off target score; where a coding sequence is targeted. In response to meeting the thresholds, the processor selects the candidate guide as a selected CRISPR guide.Type: ApplicationFiled: January 27, 2022Publication date: July 28, 2022Applicant: Recursion Pharmaceuticals, Inc.Inventors: James JENSEN, Timothy DAHLEM, Sarah HUGO, Jacob COOPER, Spencer SCHREIER, Ian QUIGLEY, Imran HAQUE, Nathan LAZAR, Alison GARDNER, Ben BANOWSKY, August ALLEN
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Patent number: 11393560Abstract: The disclosure provides methods and systems for identifying a subset of compounds in a plurality of compounds. The identifying includes obtaining, for each compound, a vector including a set of elements, where each element includes a measurement of a different feature of an instance of a cell context upon exposure to the compound. The identifying includes repeating the obtaining for a plurality of cell contexts, to obtain a plurality of vectors for each compound across different cell contexts. The identifying includes combining the vectors for each compound to form a combined vector for each compound, thereby forming a plurality of combined vectors representing different compounds. The identifying includes pruning the plurality of compounds to the subset of compounds based on a similarity between respective combined vectors in the plurality of combined vectors corresponding to compounds in the plurality of compounds.Type: GrantFiled: November 14, 2018Date of Patent: July 19, 2022Assignee: Recursion Pharmaceuticals, Inc.Inventors: Chris Gibson, Blake C. Borgeson, Mason L. Victors, David Healey, Ian Quigley, Ronald Wakim Alfa
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Publication number: 20210398619Abstract: The disclosure provides methods and systems for identifying a subset of compounds in a plurality of compounds. The identifying includes obtaining, for each compound, a vector including a set of elements, where each element includes a measurement of a different feature of an instance of a cell context upon exposure to the compound. The identifying includes performing the obtaining for a plurality of cell contexts, to obtain a plurality of vectors for each compound across different cell contexts. The identifying includes combining the vectors for each compound to form a combined vector for each compound, thereby forming a plurality of combined vectors representing different compounds. The identifying includes pruning the plurality of compounds to the subset of compounds based on a similarity between respective combined vectors in the plurality of combined vectors corresponding to compounds in the plurality of compounds.Type: ApplicationFiled: November 13, 2019Publication date: December 23, 2021Applicant: Recursion Pharmaceuticals, Inc.Inventors: Chris GIBSON, Blake C. BORGESON, Mason L. VICTORS, David HEALEY, Ian QUIGLEY, Ronald Wakim ALFA
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Publication number: 20210071256Abstract: Methods and systems are provided for determining whether a first cellular perturbation interacts with a second cellular perturbation in one of a specific cellular context and a background, in a cell based assay. Data points for one or more baseline state, perturbation state, compound state, and combination state are obtained, where the data points each include data for a plurality of cellular characteristics acquired across instances of the respective cellular state. A dimension reduction model is applied the data points to achieve a plurality of feature values from each of the data points. It is then determined whether the first cellular perturbation interacts with the second cellular perturbation in one of a specific cellular context and a background by using the features values achieved from the data points to resolve whether the combination of the gene and the compound has a threshold interaction effect on one or more cellular characteristics.Type: ApplicationFiled: September 10, 2020Publication date: March 11, 2021Applicant: Recursion Pharmaceuticals, Inc.Inventors: Ian QUIGLEY, Emery GOOSSENS
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Patent number: 10816550Abstract: Provided here are cell detection systems, fluidic devices, structures and techniques related to particle and cell sorting and detection in fluid, for example sorting specific subpopulations of cell types. A method for verification of sorting of particles includes receiving a first detection signal that is associated with optical characteristics of a particle in a first channel. A sorting channel of a plurality of second channels is determined based on the first detection signal, thereby determining the sorting of the particle into the sorting channel based on the optical characteristics of the particle. A sorting signal for sorting the particle from the first channel into the sorting channel is transmitted. A second detection signal is received that is associated with the presence of the particle in the sorting channel. The sorting of the particle from the first channel into the sorting channel is verified based on the second detection signal.Type: GrantFiled: October 15, 2013Date of Patent: October 27, 2020Assignees: NANOCELLECT BIOMEDICAL, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Sung Hwan Cho, Jose Morachis, Yuhwa Lo, Tsung-Feng Wu, Ian Quigley, Kendall Chuang, Phillip Poonka, William Alaynick
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Publication number: 20200152295Abstract: The disclosure provides methods and systems for identifying a subset of compounds in a plurality of compounds. The identifying includes obtaining, for each compound, a vector including a set of elements, where each element includes a measurement of a different feature of an instance of a cell context upon exposure to the compound. The identifying includes repeating the obtaining for a plurality of cell contexts, to obtain a plurality of vectors for each compound across different cell contexts. The identifying includes combining the vectors for each compound to form a combined vector for each compound, thereby forming a plurality of combined vectors representing different compounds. The identifying includes pruning the plurality of compounds to the subset of compounds based on a similarity between respective combined vectors in the plurality of combined vectors corresponding to compounds in the plurality of compounds.Type: ApplicationFiled: November 14, 2018Publication date: May 14, 2020Inventors: Chris Gibson, Blake C. Borgeson, Mason L. Victors, David Healey, Ian Quigley, Ronald Wakim Alfa
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Publication number: 20150268244Abstract: Provided here are cell detection systems, fluidic devices, structures and techniques related to particle and cell sorting and detection in fluid, for example sorting specific subpopulations of cell types. A method for verification of sorting of particles includes receiving a first detection signal that is associated with optical characteristics of a particle in a first channel. A sorting channel of a plurality of second channels is determined based on the first detection signal, thereby determining the sorting of the particle into the sorting channel based on the optical characteristics of the particle. A sorting signal for sorting the particle from the first channel into the sorting channel is transmitted. A second detection signal is received that is associated with the presence of the particle in the sorting channel. The sorting of the particle from the first channel into the sorting channel is verified based on the second detection signal.Type: ApplicationFiled: October 15, 2013Publication date: September 24, 2015Inventors: Sung Hwan Cho, Jose Morachis, Yuhwa Lo, Tsung-Fend Wu, Ian Quigley, Kendall Chaung, Phillip Poonka, William Alaynick